Immune thrombocytopenia and pregnancy: an exposed/nonexposed cohort study

Immune thrombocytopenia and pregnancy: an exposed/nonexposed cohort study

Abstract The risk of immune thrombocytopenia (ITP) worsening during pregnancy and neonatal ITP (NITP) have never been prospectively studied. We included 180 pregnant and 168 nonpregnant women with ITP in a prospective, multicenter, observational cohort study. A total of 131 pregnant women with ITP w...

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Veröffentlicht in:Blood 2023-01, Vol.141 (1), p.11-21
Hauptverfasser: Guillet, Stéphanie, Loustau, Valentine, Boutin, Emmanuelle, Zarour, Anissa, Comont, Thibault, Souchaud-Debouverie, Odile, Costedoat Chalumeau, Nathalie, Pan-Petesch, Brigitte, Gobert, Delphine, Cheze, Stéphane, Viallard, Jean Francois, Morin, Anne-Sophie, Sauvetre, Gaetan, Cliquennois, Manuel, Royer, Bruno, Masseau, Agathe, Terriou, Louis, Fieschi, Claire, Lambotte, Olivier, Girault, Stéphane, Lioger, Bertrand, Audia, Sylvain, Sacre, Karim, Lega, Jean Christophe, Langlois, Vincent, Benachi, Alexandra, Orvain, Corentin, Devidas, Alain, Humbert, Sebastien, Gambier, Nicolas, Ruivard, Marc, Zarrouk, Virginie, Ebbo, Mikael, Willems, Lise, Segaux, Lauriane, Mahevas, Matthieu, Haddad, Bassam, Michel, Marc, Canoui-Poitrine, Florence, Godeau, Bertrand
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Sprache:eng
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Life Sciences
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Zusammenfassung:Abstract The risk of immune thrombocytopenia (ITP) worsening during pregnancy and neonatal ITP (NITP) have never been prospectively studied. We included 180 pregnant and 168 nonpregnant women with ITP in a prospective, multicenter, observational cohort study. A total of 131 pregnant women with ITP were matched to 131 nonpregnant women with ITP by history of splenectomy, ITP status (no response, response, complete response), and duration. Groups were followed for 15 months. The primary outcome was the first occurrence of ITP worsening defined by a composite end point including bleeding events and/or severe thrombocytopenia (
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.2022017277