Doxycycline prophylaxis and meningococcal group B vaccine to prevent bacterial sexually transmitted infections in France (ANRS 174 DOXYVAC): a multicentre, open-label, randomised trial with a 2 × 2 factorial design

Increased rates of sexually transmitted infections (STIs) are reported among men who have sex with men (MSM) and new interventions are needed. We aimed to assess whether post-exposure prophylaxis (PEP) with doxycycline could reduce the incidence of chlamydia or syphilis (or both) and whether the men...

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Veröffentlicht in:	The Lancet infectious diseases 2024-10, Vol.24 (10), p.1093-1104
Hauptverfasser:	Molina, Jean-Michel, Bercot, Beatrice, Assoumou, Lambert, Rubenstein, Emma, Algarte-Genin, Michele, Pialoux, Gilles, Katlama, Christine, Surgers, Laure, Bébéar, Cécile, Dupin, Nicolas, Ouattara, Moussa, Slama, Laurence, Pavie, Juliette, Duvivier, Claudine, Loze, Benedicte, Goldwirt, Lauriane, Gibowski, Severine, Ollivier, Manon, Ghosn, Jade, Costagliola, Dominique, Aslan, Alexandre, Pintado, Claire, Delaugerre, Constance, Ponscarme, Diane, Dalle, Eve, Chas, Julie, Siguier, Martin, Palich, Romain, Valentin, Marc-Antoine, Yazdanpanah, Yazdan, Lacombe, Karine, Viard, Jean-Paul, Lourenco, Jeremy, Rachline, Anne, Detruchis, Pierre, Diemer, Myriam, Azemar, Laurene, Landowski, Stephanie, Ometsguine, Philippe, Buisson, Martin, Feliho, Philip, Bachelard, Antoine, Phung, Bao, Rioux, Christophe, Proux, Caroline, Le Gac, Sylvie, Schneider, Luminita, Charmak, Aziza, Ktorza, Nadine, Seang, Sophie, Orriere, Thibaut, Sellem, Baptiste, Palacios, Christia, Mebarki, Soraya
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adverse events Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Antibiotics Antimicrobial agents Antimicrobial resistance Chlamydia Chlamydia Infections - epidemiology Chlamydia Infections - prevention & control Disease prevention Doxycycline Doxycycline - administration & dosage Doxycycline - therapeutic use Drug resistance Emtricitabine Factorial design France - epidemiology Gonorrhea Gonorrhea - epidemiology Gonorrhea - prevention & control HIV Homosexuality, Male Human immunodeficiency virus Humans Immunization Incidence Infections Labels Life Sciences Male Men Meningococcal Vaccines - administration & dosage Microbiology and Parasitology Middle Aged Observational studies Post-Exposure Prophylaxis - methods Prophylaxis Public health Randomization Sexually transmitted diseases Sexually Transmitted Diseases, Bacterial - epidemiology Sexually Transmitted Diseases, Bacterial - prevention & control STD Syphilis Syphilis - epidemiology Syphilis - prevention & control Tenofovir Transgender persons Translation Urine Vaccines Young Adult
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