Design, Synthesis and biological evaluation of novel benzopyran derivatives as potential α-amylase inhibitors: An Investigation by Experimental and Computational Studies

•A series of new benzopyran derivatives was synthesized and characterized.•The synthesized compounds exhibited significant α-amylase inhibitory activity.•Inhibition kinetics analysis reveals two different types of inhibitory mechanism on α-amylase.•SAR evaluation and molecular docking study explaine...

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Veröffentlicht in:	Journal of molecular structure 2023-02, Vol.1273, p.134227, Article 134227
Hauptverfasser:	Hajlaoui, Amel, Assel, Amine, Lazrag, Houda, Bouajila, Jalloul, Harrath, Abdel Halim, Mansour, Lamjed, Jannet, Hichem Ben, Romdhane, Anis
Format:	Artikel
Sprache:	eng
Schlagworte:	ADMET Analytical chemistry Benzopyran Chemical engineering Chemical Sciences Kinetics Molecular docking SAR analysis α-Amylase inhibition
Online-Zugang:	Volltext
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