Comparative Analysis of Organic Extracts Bioactivity from Two Limonium. Mill Species Growing Wild in Tunisian Salty Marshes
Limonium. Mill is a genus of flowering plants belonging to the Plumbaginaceae family. The present study aimed to compare two Limonium species (L. pruinosum Kuntze and L. tunetanum (Barratte & Bonnet) Maire) in terms of their chemical composition and bioactivity. Chemical profiling showed that th...
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| Veröffentlicht in: | Chemistry & biodiversity 2023-12, Vol.20 (12), p.e202301177-n/a |
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| creator | Rahmani, Rami Debouba, Mohamed Aydi, Sameh Sassi Aydi, Samir Bouajila, Jalloul |
| description | Limonium. Mill is a genus of flowering plants belonging to the Plumbaginaceae family. The present study aimed to compare two Limonium species (L. pruinosum Kuntze and L. tunetanum (Barratte & Bonnet) Maire) in terms of their chemical composition and bioactivity. Chemical profiling showed that the methanolic (MeOH) extracts of both species were the most enriched with total phenolic (TP) and total flavonoid (TF) contents. The TFC were higher in L. tunetanum compared to L. pruinosum. HPLC‐DAD analysis showed that distinctly the gallic acid and L‐tyrosine 7‐amido‐4‐methylcoumarin were the main compounds for L. pruinosum and L. tunetanum, respectively. For both Limonium. Mil species, the MeOH extracts displayed the highest antioxidant with IC50 of 7.7 and 8.4 μg/mL for L. pruinosum and L. tunetanum, respectively. The highest anti‐15‐lipoxygnase activity was recorded in the ethyl acetate (IC50=14.2 μg/mL) and Methanol (IC50=15.6 μg/mL) extracts for L. pruinosum. However, for L. tunetanum the best activity was recorded for dichloromethane extract (IC50=10.4 μg/mL). L. pruinosum extracts displayed the highest cytotoxic activity against MCF‐7 and HCT‐116 cell lines compared to L. tunetanum ones. The obtained bioactivity discrepancy between Limonium. Mill species was discussed in relation to the organic extract chemical richness. |
| doi_str_mv | 10.1002/cbdv.202301177 |
| format | Article |
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Mill Species Growing Wild in Tunisian Salty Marshes</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Rahmani, Rami ; Debouba, Mohamed ; Aydi, Sameh Sassi ; Aydi, Samir ; Bouajila, Jalloul</creator><creatorcontrib>Rahmani, Rami ; Debouba, Mohamed ; Aydi, Sameh Sassi ; Aydi, Samir ; Bouajila, Jalloul</creatorcontrib><description>Limonium. Mill is a genus of flowering plants belonging to the Plumbaginaceae family. The present study aimed to compare two Limonium species (L. pruinosum Kuntze and L. tunetanum (Barratte & Bonnet) Maire) in terms of their chemical composition and bioactivity. Chemical profiling showed that the methanolic (MeOH) extracts of both species were the most enriched with total phenolic (TP) and total flavonoid (TF) contents. The TFC were higher in L. tunetanum compared to L. pruinosum. HPLC‐DAD analysis showed that distinctly the gallic acid and L‐tyrosine 7‐amido‐4‐methylcoumarin were the main compounds for L. pruinosum and L. tunetanum, respectively. For both Limonium. Mil species, the MeOH extracts displayed the highest antioxidant with IC50 of 7.7 and 8.4 μg/mL for L. pruinosum and L. tunetanum, respectively. The highest anti‐15‐lipoxygnase activity was recorded in the ethyl acetate (IC50=14.2 μg/mL) and Methanol (IC50=15.6 μg/mL) extracts for L. pruinosum. However, for L. tunetanum the best activity was recorded for dichloromethane extract (IC50=10.4 μg/mL). L. pruinosum extracts displayed the highest cytotoxic activity against MCF‐7 and HCT‐116 cell lines compared to L. tunetanum ones. The obtained bioactivity discrepancy between Limonium. Mill species was discussed in relation to the organic extract chemical richness.</description><identifier>ISSN: 1612-1872</identifier><identifier>EISSN: 1612-1880</identifier><identifier>DOI: 10.1002/cbdv.202301177</identifier><identifier>PMID: 37926684</identifier><language>eng</language><publisher>Switzerland: Wiley Subscription Services, Inc</publisher><subject>Acetic acid ; Analytical chemistry ; Antineoplastic Agents ; antioxidant ; Antioxidants - chemistry ; Antioxidants - pharmacology ; bioactivity ; Biological activity ; Cell lines ; Chemical composition ; Chemical engineering ; Chemical Sciences ; chromatography ; Comparative analysis ; Cytotoxicity ; Dichloromethane ; Ethyl acetate ; Flavonoids ; Flavonoids - chemistry ; Flavonoids - pharmacology ; Flowering ; Flowering plants ; Gallic acid ; Limonium ; Limonium pruinosum Kuntze ; Limonium tunetanum (Barratte & Bonnet) Maire ; Liquid chromatography ; Medicinal plant ; Phenolic compounds ; Phenols ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plants (botany) ; Plumbaginaceae - chemistry ; Species ; Tyrosine ; Wetlands</subject><ispartof>Chemistry & biodiversity, 2023-12, Vol.20 (12), p.e202301177-n/a</ispartof><rights>2023 Wiley‐VHCA AG, Zurich, Switzerland</rights><rights>2023 Wiley-VHCA AG, Zurich, Switzerland.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4027-6c009aa7e5b3b75c5687e76dd5515ff4927166ae034bde84aedbbb8eae75dad03</cites><orcidid>0000-0002-6473-6143 ; 0000-0002-2439-5145</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcbdv.202301177$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcbdv.202301177$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37926684$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04754704$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Rahmani, Rami</creatorcontrib><creatorcontrib>Debouba, Mohamed</creatorcontrib><creatorcontrib>Aydi, Sameh Sassi</creatorcontrib><creatorcontrib>Aydi, Samir</creatorcontrib><creatorcontrib>Bouajila, Jalloul</creatorcontrib><title>Comparative Analysis of Organic Extracts Bioactivity from Two Limonium. Mill Species Growing Wild in Tunisian Salty Marshes</title><title>Chemistry & biodiversity</title><addtitle>Chem Biodivers</addtitle><description>Limonium. Mill is a genus of flowering plants belonging to the Plumbaginaceae family. The present study aimed to compare two Limonium species (L. pruinosum Kuntze and L. tunetanum (Barratte & Bonnet) Maire) in terms of their chemical composition and bioactivity. Chemical profiling showed that the methanolic (MeOH) extracts of both species were the most enriched with total phenolic (TP) and total flavonoid (TF) contents. The TFC were higher in L. tunetanum compared to L. pruinosum. HPLC‐DAD analysis showed that distinctly the gallic acid and L‐tyrosine 7‐amido‐4‐methylcoumarin were the main compounds for L. pruinosum and L. tunetanum, respectively. For both Limonium. Mil species, the MeOH extracts displayed the highest antioxidant with IC50 of 7.7 and 8.4 μg/mL for L. pruinosum and L. tunetanum, respectively. The highest anti‐15‐lipoxygnase activity was recorded in the ethyl acetate (IC50=14.2 μg/mL) and Methanol (IC50=15.6 μg/mL) extracts for L. pruinosum. However, for L. tunetanum the best activity was recorded for dichloromethane extract (IC50=10.4 μg/mL). L. pruinosum extracts displayed the highest cytotoxic activity against MCF‐7 and HCT‐116 cell lines compared to L. tunetanum ones. The obtained bioactivity discrepancy between Limonium. Mill species was discussed in relation to the organic extract chemical richness.</description><subject>Acetic acid</subject><subject>Analytical chemistry</subject><subject>Antineoplastic Agents</subject><subject>antioxidant</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - pharmacology</subject><subject>bioactivity</subject><subject>Biological activity</subject><subject>Cell lines</subject><subject>Chemical composition</subject><subject>Chemical engineering</subject><subject>Chemical Sciences</subject><subject>chromatography</subject><subject>Comparative analysis</subject><subject>Cytotoxicity</subject><subject>Dichloromethane</subject><subject>Ethyl acetate</subject><subject>Flavonoids</subject><subject>Flavonoids - chemistry</subject><subject>Flavonoids - pharmacology</subject><subject>Flowering</subject><subject>Flowering plants</subject><subject>Gallic acid</subject><subject>Limonium</subject><subject>Limonium pruinosum Kuntze</subject><subject>Limonium tunetanum (Barratte & Bonnet) Maire</subject><subject>Liquid chromatography</subject><subject>Medicinal plant</subject><subject>Phenolic compounds</subject><subject>Phenols</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plants (botany)</subject><subject>Plumbaginaceae - chemistry</subject><subject>Species</subject><subject>Tyrosine</subject><subject>Wetlands</subject><issn>1612-1872</issn><issn>1612-1880</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c9v0zAUB_AIMbExuHJElriwQ4ud-Edy7MrYkDrtsAJH68Vxtjc5cWcn7Sr-eVx1dBIXTs96-rwn632z7AOjU0Zp_sXUzXqa07ygjCn1KjthkuUTVpb09eGt8uPsbYwPyad--SY7LlSVS1nyk-z33HcrCDDg2pJZD24bMRLfkptwBz0acvE0BDBDJOfoU8U1DlvSBt-R5caTBXa-x7Gbkmt0jtyurEEbyWXwG-zvyC90DcGeLMceI0JPbsGl8WsI8d7Gd9lRCy7a98_1NPvx7WI5v5osbi6_z2eLieE0VxNpKK0AlBV1USthhCyVVbJphGCibXmVKyYlWFrwurElB9vUdV1asEo00NDiNDvb770Hp1cBOwhb7QH11Wyhdz3KleCK8jVL9vPeroJ_HG0cdIfRWOegt36MOl1Qiqrkkif66R_64MeQTphURYtSiCrfqelemeBjDLY9_IBRvYtQ7yLUhwjTwMfntWPd2ebA_2aWQLUHG3R2-591en7-9efL8j8o-6hV</recordid><startdate>202312</startdate><enddate>202312</enddate><creator>Rahmani, Rami</creator><creator>Debouba, Mohamed</creator><creator>Aydi, Sameh Sassi</creator><creator>Aydi, Samir</creator><creator>Bouajila, Jalloul</creator><general>Wiley Subscription Services, Inc</general><general>Wiley</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-6473-6143</orcidid><orcidid>https://orcid.org/0000-0002-2439-5145</orcidid></search><sort><creationdate>202312</creationdate><title>Comparative Analysis of Organic Extracts Bioactivity from Two Limonium. Mill Species Growing Wild in Tunisian Salty Marshes</title><author>Rahmani, Rami ; Debouba, Mohamed ; Aydi, Sameh Sassi ; Aydi, Samir ; Bouajila, Jalloul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4027-6c009aa7e5b3b75c5687e76dd5515ff4927166ae034bde84aedbbb8eae75dad03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acetic acid</topic><topic>Analytical chemistry</topic><topic>Antineoplastic Agents</topic><topic>antioxidant</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - pharmacology</topic><topic>bioactivity</topic><topic>Biological activity</topic><topic>Cell lines</topic><topic>Chemical composition</topic><topic>Chemical engineering</topic><topic>Chemical Sciences</topic><topic>chromatography</topic><topic>Comparative analysis</topic><topic>Cytotoxicity</topic><topic>Dichloromethane</topic><topic>Ethyl acetate</topic><topic>Flavonoids</topic><topic>Flavonoids - chemistry</topic><topic>Flavonoids - pharmacology</topic><topic>Flowering</topic><topic>Flowering plants</topic><topic>Gallic acid</topic><topic>Limonium</topic><topic>Limonium pruinosum Kuntze</topic><topic>Limonium tunetanum (Barratte & Bonnet) Maire</topic><topic>Liquid chromatography</topic><topic>Medicinal plant</topic><topic>Phenolic compounds</topic><topic>Phenols</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plants (botany)</topic><topic>Plumbaginaceae - chemistry</topic><topic>Species</topic><topic>Tyrosine</topic><topic>Wetlands</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rahmani, Rami</creatorcontrib><creatorcontrib>Debouba, Mohamed</creatorcontrib><creatorcontrib>Aydi, Sameh Sassi</creatorcontrib><creatorcontrib>Aydi, Samir</creatorcontrib><creatorcontrib>Bouajila, Jalloul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Chemistry & biodiversity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rahmani, Rami</au><au>Debouba, Mohamed</au><au>Aydi, Sameh Sassi</au><au>Aydi, Samir</au><au>Bouajila, Jalloul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative Analysis of Organic Extracts Bioactivity from Two Limonium. Mill Species Growing Wild in Tunisian Salty Marshes</atitle><jtitle>Chemistry & biodiversity</jtitle><addtitle>Chem Biodivers</addtitle><date>2023-12</date><risdate>2023</risdate><volume>20</volume><issue>12</issue><spage>e202301177</spage><epage>n/a</epage><pages>e202301177-n/a</pages><issn>1612-1872</issn><eissn>1612-1880</eissn><abstract>Limonium. Mill is a genus of flowering plants belonging to the Plumbaginaceae family. The present study aimed to compare two Limonium species (L. pruinosum Kuntze and L. tunetanum (Barratte & Bonnet) Maire) in terms of their chemical composition and bioactivity. Chemical profiling showed that the methanolic (MeOH) extracts of both species were the most enriched with total phenolic (TP) and total flavonoid (TF) contents. The TFC were higher in L. tunetanum compared to L. pruinosum. HPLC‐DAD analysis showed that distinctly the gallic acid and L‐tyrosine 7‐amido‐4‐methylcoumarin were the main compounds for L. pruinosum and L. tunetanum, respectively. For both Limonium. Mil species, the MeOH extracts displayed the highest antioxidant with IC50 of 7.7 and 8.4 μg/mL for L. pruinosum and L. tunetanum, respectively. The highest anti‐15‐lipoxygnase activity was recorded in the ethyl acetate (IC50=14.2 μg/mL) and Methanol (IC50=15.6 μg/mL) extracts for L. pruinosum. However, for L. tunetanum the best activity was recorded for dichloromethane extract (IC50=10.4 μg/mL). L. pruinosum extracts displayed the highest cytotoxic activity against MCF‐7 and HCT‐116 cell lines compared to L. tunetanum ones. The obtained bioactivity discrepancy between Limonium. Mill species was discussed in relation to the organic extract chemical richness.</abstract><cop>Switzerland</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37926684</pmid><doi>10.1002/cbdv.202301177</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-6473-6143</orcidid><orcidid>https://orcid.org/0000-0002-2439-5145</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acetic acid Analytical chemistry Antineoplastic Agents antioxidant Antioxidants - chemistry Antioxidants - pharmacology bioactivity Biological activity Cell lines Chemical composition Chemical engineering Chemical Sciences chromatography Comparative analysis Cytotoxicity Dichloromethane Ethyl acetate Flavonoids Flavonoids - chemistry Flavonoids - pharmacology Flowering Flowering plants Gallic acid Limonium Limonium pruinosum Kuntze Limonium tunetanum (Barratte & Bonnet) Maire Liquid chromatography Medicinal plant Phenolic compounds Phenols Plant Extracts - chemistry Plant Extracts - pharmacology Plants (botany) Plumbaginaceae - chemistry Species Tyrosine Wetlands |
| title | Comparative Analysis of Organic Extracts Bioactivity from Two Limonium. Mill Species Growing Wild in Tunisian Salty Marshes |
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