Human NLRC4 expression promotes cancer survival and associates with type I interferon signaling and immune infiltration

The immune system can control cancer progression. However, even though some innate immune sensors of cellular stress are expressed intrinsically in epithelial cells, their potential role in cancer aggressiveness and subsequent overall survival in humans is mainly unknown. Here, we show that nucleoti...

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Veröffentlicht in:	The Journal of clinical investigation 2024-06, Vol.134 (11)
Hauptverfasser:	Domblides, Charlotte, Crampton, Steven, Liu, Hong, Bartleson, Juliet M, Nguyen, Annie, Champagne, Claudia, Landy, Emily E, Spiker, Lindsey, Proffitt, Christopher, Bhattarai, Sunil, Grawe, Anissa P, Fuentealba Valenzuela, Matias, Lartigue, Lydia, Mahouche, Isabelle, Dupaul-Chicoine, Jeremy, Nishimura, Kazuho, Lefort, Félix, Decraecker, Marie, Velasco, Valérie, Netzer, Sonia, Pitard, Vincent, Roy, Christian, Soubeyran, Isabelle, Racine, Victor, Blanco, Patrick, Déchanet-Merville, Julie, Saleh, Maya, Canna, Scott W, Furman, David, Faustin, Benjamin
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Calcium-Binding Proteins - genetics CARD Signaling Adaptor Proteins - genetics CARD Signaling Adaptor Proteins - metabolism Cell Line, Tumor Cell receptors Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - immunology Colorectal Neoplasms - pathology Dendritic Cells - immunology Dendritic Cells - metabolism Development and progression Female Gene Expression Regulation, Neoplastic Health aspects Humans Identification and classification Immune response Interferon Interferon Type I - genetics Interferon Type I - immunology Interferon Type I - metabolism Life Sciences Lymphocytes, Tumor-Infiltrating - immunology Male Neoplasm Proteins - genetics Neoplasm Proteins - immunology Physiological aspects Prognosis Risk factors Signal Transduction
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