The genetics of immune and infection phenotypes in wild mice, Mus musculus domesticus

Wild animals are under constant threat from a wide range of micro‐ and macroparasites in their environment. Animals make immune responses against parasites, and these are important in affecting the dynamics of parasite populations. Individual animals vary in their anti‐parasite immune responses. Gen...

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Veröffentlicht in:Molecular ecology 2023-08, Vol.32 (15), p.4242-4258
Hauptverfasser: Cheynel, Louise, Lazarou, Luke, Riley, Eleanor M., Viney, Mark
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container_title Molecular ecology
container_volume 32
creator Cheynel, Louise
Lazarou, Luke
Riley, Eleanor M.
Viney, Mark
description Wild animals are under constant threat from a wide range of micro‐ and macroparasites in their environment. Animals make immune responses against parasites, and these are important in affecting the dynamics of parasite populations. Individual animals vary in their anti‐parasite immune responses. Genetic polymorphism of immune‐related loci contributes to inter‐individual differences in immune responses, but most of what we know in this regard comes from studies of humans or laboratory animals; there are very few such studies of wild animals naturally infected with parasites. Here we have investigated the effect of single nucleotide polymorphisms (SNPs) in immune‐related loci (the major histocompatibility complex [MHC], and loci coding for cytokines and Toll‐like receptors) on a wide range of immune and infection phenotypes in UK wild house mice, Mus musculus domesticus. We found strong associations between SNPs in various MHC and cytokine‐coding loci on both immune measures (antibody concentration and cytokine production) and on infection phenotypes (infection with mites, worms and viruses). Our study provides a comprehensive view of how polymorphism of immune‐related loci affects immune and infection phenotypes in naturally infected wild rodent populations.
doi_str_mv 10.1111/mec.17027
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source MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects Animal biology
Animals
Animals, Wild - genetics
Antibodies
cytokine
Cytokines
Cytokines - genetics
ecoimmunology
Ecology, environment
Ectoparasites
Gene polymorphism
Genetics
Immune response
Infections
Laboratory animals
Life Sciences
major histocompatibility
Major histocompatibility complex
Mice
mouse
Mus musculus domesticus
Nucleotides
parasite
Parasites
Phenotype
Phenotypes
Polymorphism
Polymorphism, Single Nucleotide
Populations
Single-nucleotide polymorphism
Viruses
wild
title The genetics of immune and infection phenotypes in wild mice, Mus musculus domesticus
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