The genetics of immune and infection phenotypes in wild mice, Mus musculus domesticus
Wild animals are under constant threat from a wide range of micro‐ and macroparasites in their environment. Animals make immune responses against parasites, and these are important in affecting the dynamics of parasite populations. Individual animals vary in their anti‐parasite immune responses. Gen...
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Veröffentlicht in: | Molecular ecology 2023-08, Vol.32 (15), p.4242-4258 |
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description | Wild animals are under constant threat from a wide range of micro‐ and macroparasites in their environment. Animals make immune responses against parasites, and these are important in affecting the dynamics of parasite populations. Individual animals vary in their anti‐parasite immune responses. Genetic polymorphism of immune‐related loci contributes to inter‐individual differences in immune responses, but most of what we know in this regard comes from studies of humans or laboratory animals; there are very few such studies of wild animals naturally infected with parasites. Here we have investigated the effect of single nucleotide polymorphisms (SNPs) in immune‐related loci (the major histocompatibility complex [MHC], and loci coding for cytokines and Toll‐like receptors) on a wide range of immune and infection phenotypes in UK wild house mice, Mus musculus domesticus. We found strong associations between SNPs in various MHC and cytokine‐coding loci on both immune measures (antibody concentration and cytokine production) and on infection phenotypes (infection with mites, worms and viruses). Our study provides a comprehensive view of how polymorphism of immune‐related loci affects immune and infection phenotypes in naturally infected wild rodent populations. |
doi_str_mv | 10.1111/mec.17027 |
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Animals make immune responses against parasites, and these are important in affecting the dynamics of parasite populations. Individual animals vary in their anti‐parasite immune responses. Genetic polymorphism of immune‐related loci contributes to inter‐individual differences in immune responses, but most of what we know in this regard comes from studies of humans or laboratory animals; there are very few such studies of wild animals naturally infected with parasites. Here we have investigated the effect of single nucleotide polymorphisms (SNPs) in immune‐related loci (the major histocompatibility complex [MHC], and loci coding for cytokines and Toll‐like receptors) on a wide range of immune and infection phenotypes in UK wild house mice, Mus musculus domesticus. We found strong associations between SNPs in various MHC and cytokine‐coding loci on both immune measures (antibody concentration and cytokine production) and on infection phenotypes (infection with mites, worms and viruses). Our study provides a comprehensive view of how polymorphism of immune‐related loci affects immune and infection phenotypes in naturally infected wild rodent populations.</description><identifier>ISSN: 0962-1083</identifier><identifier>EISSN: 1365-294X</identifier><identifier>DOI: 10.1111/mec.17027</identifier><identifier>PMID: 37259895</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Animal biology ; Animals ; Animals, Wild - genetics ; Antibodies ; cytokine ; Cytokines ; Cytokines - genetics ; ecoimmunology ; Ecology, environment ; Ectoparasites ; Gene polymorphism ; Genetics ; Immune response ; Infections ; Laboratory animals ; Life Sciences ; major histocompatibility ; Major histocompatibility complex ; Mice ; mouse ; Mus musculus domesticus ; Nucleotides ; parasite ; Parasites ; Phenotype ; Phenotypes ; Polymorphism ; Polymorphism, Single Nucleotide ; Populations ; Single-nucleotide polymorphism ; Viruses ; wild</subject><ispartof>Molecular ecology, 2023-08, Vol.32 (15), p.4242-4258</ispartof><rights>2023 The Authors. published by John Wiley & Sons Ltd.</rights><rights>2023 The Authors. Molecular Ecology published by John Wiley & Sons Ltd.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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Animals make immune responses against parasites, and these are important in affecting the dynamics of parasite populations. Individual animals vary in their anti‐parasite immune responses. Genetic polymorphism of immune‐related loci contributes to inter‐individual differences in immune responses, but most of what we know in this regard comes from studies of humans or laboratory animals; there are very few such studies of wild animals naturally infected with parasites. Here we have investigated the effect of single nucleotide polymorphisms (SNPs) in immune‐related loci (the major histocompatibility complex [MHC], and loci coding for cytokines and Toll‐like receptors) on a wide range of immune and infection phenotypes in UK wild house mice, Mus musculus domesticus. We found strong associations between SNPs in various MHC and cytokine‐coding loci on both immune measures (antibody concentration and cytokine production) and on infection phenotypes (infection with mites, worms and viruses). Our study provides a comprehensive view of how polymorphism of immune‐related loci affects immune and infection phenotypes in naturally infected wild rodent populations.</description><subject>Animal biology</subject><subject>Animals</subject><subject>Animals, Wild - genetics</subject><subject>Antibodies</subject><subject>cytokine</subject><subject>Cytokines</subject><subject>Cytokines - genetics</subject><subject>ecoimmunology</subject><subject>Ecology, environment</subject><subject>Ectoparasites</subject><subject>Gene polymorphism</subject><subject>Genetics</subject><subject>Immune response</subject><subject>Infections</subject><subject>Laboratory animals</subject><subject>Life Sciences</subject><subject>major histocompatibility</subject><subject>Major histocompatibility complex</subject><subject>Mice</subject><subject>mouse</subject><subject>Mus musculus domesticus</subject><subject>Nucleotides</subject><subject>parasite</subject><subject>Parasites</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Populations</subject><subject>Single-nucleotide polymorphism</subject><subject>Viruses</subject><subject>wild</subject><issn>0962-1083</issn><issn>1365-294X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kU1rGzEQhkVpaJy0h_6BIuglgayjr11Jx2DyUbDJJYHexK40WyusVu7KavG_jxInKRSii8Tw8GhmXoS-UjKn5ZwHsHMqCZMf0Izypq6YFj8_ohnRDasoUfwQHaX0QAjlrK4_oUMuWa2Vrmfo_m4N-BeMsPU24dhjH0IeAbejw37swW59HPFmDWPc7jaQShH_9YPDwVs4w6uccMjJ5qE8XAyQiienz-igb4cEX17uY3R_dXm3uKmWt9c_FhfLynLFZMWZ7l3bK0c0IV1DieQ96A54GUY6pZhQ2nHQFmrqNGkUI0KwvqNNx4SwDT9Gp3vvuh3MZvKhnXYmtt7cXCzNU40IKWol6R9a2JM9u5ni71waNcEnC8PQjhBzMkwx2gguiSjo9__Qh5insUxSKEF0zWlD_31up5jSBP1bB5SYp1xMycU851LYby_G3AVwb-RrEAU43wNlubB732RWl4u98hGv4JRm</recordid><startdate>202308</startdate><enddate>202308</enddate><creator>Cheynel, Louise</creator><creator>Lazarou, Luke</creator><creator>Riley, Eleanor M.</creator><creator>Viney, Mark</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SN</scope><scope>7SS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0003-2292-4143</orcidid></search><sort><creationdate>202308</creationdate><title>The genetics of immune and infection phenotypes in wild mice, Mus musculus domesticus</title><author>Cheynel, Louise ; Lazarou, Luke ; Riley, Eleanor M. ; Viney, Mark</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3827-329fdaf8d0900b61073fe9be31707d882489d3e9ce51d906820442fb16b244c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animal biology</topic><topic>Animals</topic><topic>Animals, Wild - genetics</topic><topic>Antibodies</topic><topic>cytokine</topic><topic>Cytokines</topic><topic>Cytokines - genetics</topic><topic>ecoimmunology</topic><topic>Ecology, environment</topic><topic>Ectoparasites</topic><topic>Gene polymorphism</topic><topic>Genetics</topic><topic>Immune response</topic><topic>Infections</topic><topic>Laboratory animals</topic><topic>Life Sciences</topic><topic>major histocompatibility</topic><topic>Major histocompatibility complex</topic><topic>Mice</topic><topic>mouse</topic><topic>Mus musculus domesticus</topic><topic>Nucleotides</topic><topic>parasite</topic><topic>Parasites</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Populations</topic><topic>Single-nucleotide polymorphism</topic><topic>Viruses</topic><topic>wild</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheynel, Louise</creatorcontrib><creatorcontrib>Lazarou, Luke</creatorcontrib><creatorcontrib>Riley, Eleanor M.</creatorcontrib><creatorcontrib>Viney, Mark</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Molecular ecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheynel, Louise</au><au>Lazarou, Luke</au><au>Riley, Eleanor M.</au><au>Viney, Mark</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The genetics of immune and infection phenotypes in wild mice, Mus musculus domesticus</atitle><jtitle>Molecular ecology</jtitle><addtitle>Mol Ecol</addtitle><date>2023-08</date><risdate>2023</risdate><volume>32</volume><issue>15</issue><spage>4242</spage><epage>4258</epage><pages>4242-4258</pages><issn>0962-1083</issn><eissn>1365-294X</eissn><abstract>Wild animals are under constant threat from a wide range of micro‐ and macroparasites in their environment. Animals make immune responses against parasites, and these are important in affecting the dynamics of parasite populations. Individual animals vary in their anti‐parasite immune responses. Genetic polymorphism of immune‐related loci contributes to inter‐individual differences in immune responses, but most of what we know in this regard comes from studies of humans or laboratory animals; there are very few such studies of wild animals naturally infected with parasites. Here we have investigated the effect of single nucleotide polymorphisms (SNPs) in immune‐related loci (the major histocompatibility complex [MHC], and loci coding for cytokines and Toll‐like receptors) on a wide range of immune and infection phenotypes in UK wild house mice, Mus musculus domesticus. We found strong associations between SNPs in various MHC and cytokine‐coding loci on both immune measures (antibody concentration and cytokine production) and on infection phenotypes (infection with mites, worms and viruses). 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subjects | Animal biology Animals Animals, Wild - genetics Antibodies cytokine Cytokines Cytokines - genetics ecoimmunology Ecology, environment Ectoparasites Gene polymorphism Genetics Immune response Infections Laboratory animals Life Sciences major histocompatibility Major histocompatibility complex Mice mouse Mus musculus domesticus Nucleotides parasite Parasites Phenotype Phenotypes Polymorphism Polymorphism, Single Nucleotide Populations Single-nucleotide polymorphism Viruses wild |
title | The genetics of immune and infection phenotypes in wild mice, Mus musculus domesticus |
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