Thermodynamics in Neurodegenerative Diseases: Interplay Between Canonical WNT/Beta-Catenin Pathway–PPAR Gamma, Energy Metabolism and Circadian Rhythms

Entropy production rate is increased by several metabolic and thermodynamics abnormalities in neurodegenerative diseases (NDs). Irreversible processes are quantified by changes in the entropy production rate. This review is focused on the opposing interactions observed in NDs between the canonical W...

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Veröffentlicht in:	Neuromolecular medicine 2018-06, Vol.20 (2), p.174-204
Hauptverfasser:	Vallée, Alexandre, Lecarpentier, Yves, Guillevin, Rémy, Vallée, Jean-Noël
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - biosynthesis Aerobiosis Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - physiopathology Biomedical and Life Sciences Biomedicine Brain - metabolism Cell death Circadian Rhythm Circadian rhythms Cognitive science Dehydrogenases Disease Energy Metabolism Entropy Enzymes Glucose transporter Glycolysis Humans Huntington Disease - metabolism Huntington Disease - physiopathology Internal Medicine Lactic acid Melatonin - metabolism Metabolism Models, Biological Neurodegenerative diseases Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - physiopathology Neurology Neuroscience Neurosciences Oxidative Stress Parkinson Disease - metabolism Parkinson Disease - physiopathology Peroxisome proliferator-activated receptors PPAR gamma - agonists PPAR gamma - biosynthesis PPAR gamma - physiology Pyruvate dehydrogenase (lipoamide) Pyruvate kinase Pyruvic acid Review Paper Thermodynamics Wnt protein Wnt Signaling Pathway β-Catenin
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