Phenotypic, transcriptomic, and spatial characterization of CD45RB+ naïve mature B cells: Implications in Sjögren's disease

The conventional classification of mature B cells overlooks the diversity within IgD+ CD27− naïve B cells. Here, to identify distinct mature naïve B cells, we categorized CD45RBMEM55- B cells (NA RB-) and CD45RBMEM55+ B cells (NA RB+) and explore their function and localization in circulation and ti...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2024-11, Vol.268, p.110378, Article 110378
Hauptverfasser:	Boudigou, Marina, Frutoso, Marie, Hémon, Patrice, Le Dantec, Christelle, Chatzis, Loukas, Devauchelle, Valérie, Jamin, Christophe, Cornec, Divi, Pers, Jacques-Olivier, Le Pottier, Laëtitia, Hillion, Sophie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult B-Lymphocytes - immunology CD45RB+CD45RAhigh IgD+CD27− human B cells Cell Differentiation - immunology Female High parameter imaging mass cytometry Humans Immunoglobulin M - immunology Immunology Inflamed tissues Leukocyte Common Antigens - genetics Leukocyte Common Antigens - immunology Leukocyte Common Antigens - metabolism Life Sciences Male Middle Aged Phenotype Salivary Glands - immunology Sjogren's Syndrome - genetics Sjogren's Syndrome - immunology Sjögren's disease Transcriptome
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