Neutralizing protease Nexin-1 in hemophilia patients on emicizumab improves thrombin generation

•Blocking PN-1 has been shown to control bleeding and improve hemostasis in hemophilia.•PN-1 blockade can accelerate the thrombin burst in blood from patients on emicizumab.•PN-1 blockade has no impact on fibrinolysis in blood from patients on emicizumab.•Patients receiving emicizumab may benefit fr...

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Veröffentlicht in:	Thrombosis research 2024-11, Vol.243, p.109174, Article 109174
Hauptverfasser:	Arocas, Véronique, Venisse, Laurence, Boulaftali, Yacine, Loyau, Stéphane, Flaujac, Claire, de Raucourt, Emmanuelle, Bouton, Marie-Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticoagulant protein Emicizumab Hemophilia Life Sciences Serpin E2
Online-Zugang:	Volltext
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