Endothelial force sensing signals to parenchymal cells to regulate bile and plasma lipids

How cardiovascular activity interacts with lipid homeostasis is incompletely understood. We postulated a role for blood flow acting at endothelium in lipid regulatory organs. Transcriptome analysis was performed on livers from mice engineered for deletion of the flow-sensing PIEZO1 channel in endoth...

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Veröffentlicht in:	Science advances 2024-09, Vol.10 (39), p.eadq3075
Hauptverfasser:	Lichtenstein, Laeticia, Cheng, Chew W, Bajarwan, Muath, Evans, Elizabeth L, Gaunt, Hannah J, Bartoli, Fiona, Chuntharpursat-Bon, Eulashini, Patel, Shaili, Konstantinou, Charalampos, Futers, T Simon, Reay, Melanie, Parsonage, Gregory, Moore, J Bernadette, Bertrand-Michel, Justine, Sukumar, Piruthivi, Roberts, Lee D, Beech, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile - metabolism Bile Acids and Salts - metabolism Cholesterol - blood Cholesterol - metabolism Cholesterol 7-alpha-Hydroxylase - genetics Cholesterol 7-alpha-Hydroxylase - metabolism Endothelial Cells - metabolism Endothelium - metabolism Hepatocytes - metabolism Humans Ion Channels - genetics Ion Channels - metabolism Life Sciences Lipid Metabolism Lipids - blood Liver - metabolism Mice Nitric Oxide - metabolism Nitric Oxide Synthase Type III - genetics Nitric Oxide Synthase Type III - metabolism
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