Preclinical in vivo assessment of the activity of AZD7442 anti-SARS-CoV-2 monoclonal antibodies against Omicron sublineages

Therapeutic monoclonal antibodies have been successful in protecting vulnerable populations against SARS-CoV-2. However, their effectiveness has been hampered by the emergence of new variants. To adapt the therapeutic landscape, health authorities have based their recommendations mostly on in vitro...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2024-08, Vol.177, p.116988, Article 116988
Hauptverfasser:	Driouich, Jean-Sélim, Cochin, Maxime, Lingas, Guillaume, Luciani, Léa, Baronti, Cécile, Bernadin, Ornéllie, Gilles, Magali, Villarroel, Paola Mariela Saba, Moureau, Grégory, Petit, Paul-Rémi, Dupont, Axelle, Izopet, Jacques, Kamar, Nassim, Autran, Brigitte, Paintaud, Gilles, Caillard, Sophie, le Bourgeois, Amandine, Richez, Christophe, Couzi, Lionel, Xhaard, Aliénor, Marjanovic, Zora, Avouac, Jerome, Jacquet, Caroline, Anglicheau, Dany, Cheminant, Morgane, Nguyen, Stéphanie, Terrier, Benjamin, Gottenberg, Jacques Eric, Besson, Caroline, Letrou, Sophie, Tine, Josephine, Basilua, Joe Miantezila, Angoulvant, Denis, Tardivon, Coralie, Blancho, Gilles, Martin-Blondel, Guillaume, Yazdanpanah, Yazdan, Mentré, France, Lévy, Vincent, Touret, Franck, Guedj, Jérémie, de Lamballerie, Xavier, Nougairède, Antoine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal / immunology Antibodies, Monoclonal / pharmacology Antibodies, Monoclonal, Humanized / pharmacology Antibodies, Monoclonal, Humanized / therapeutic use Antibodies, Viral / blood Antibodies, Viral / immunology Antiviral Agents / pharmacology Antiviral Agents / therapeutic use AZD7442 Betacoronavirus / drug effects Betacoronavirus / immunology Clinical therapeutics COVID-19 / immunology COVID-19 / virology COVID-19 Drug Treatment Cricetinae Disease Models, Animal Drug Evaluation, Preclinical / methods Female Humans Life Sciences Male Mesocricetus Monoclonal antibody Omicron sublineages Preclinical animal model SARS-CoV-2 SARS-CoV-2 / drug effects SARS-CoV-2 / immunology
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