New potent EV-A71 antivirals targeting capsid

The enterovirus is a genus of single-stranded, highly diverse positive-sense RNA viruses, including Human Enterovirus A-D and Human Rhinovirus A-C species. They are responsible for numerous diseases and some infections can progress to life-threatening complications, particularly in children or immun...

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Veröffentlicht in:	European journal of medicinal chemistry 2024-10, Vol.276, p.116658, Article 116658
Hauptverfasser:	Roux, Hugo, Touret, Franck, Coluccia, Antonio, Khoumeri, Omar, Di Giorgio, Carole, Majdi, Chaimae, Sciò, Pietro, Silvestri, Romano, Vanelle, Patrice, Roche, Manon
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Capsid - drug effects Capsid - metabolism Capsid binder Capsid Proteins - antagonists & inhibitors Capsid Proteins - chemistry Capsid Proteins - metabolism Dose-Response Relationship, Drug Enterovirus A, Human - drug effects EV-A71 Heterocyclic compounds Humans Life Sciences Microbial Sensitivity Tests Molecular Structure Structure-Activity Relationship Structure-activity relationships Structure-based drug design
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