Impact of age on tumor size in vulvar cancer: A multicenter study by the Francogyn group
Vulvar cancer is a rare pathology affecting mainly elderly women. This study aims to evaluate the impact of age on tumor size in vulvar cancer. This was a multicenter retrospective observational study carried out between January 1, 1998, and December 31, 2020, in patients operated on for vulvar canc...
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| Veröffentlicht in: | European journal of surgical oncology 2024-09, Vol.50 (9), p.108482, Article 108482 |
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| creator | Raimond, E. Kerbage, Y. Ouldamer, L. Bendifallah, S. Carcopino, X. Koskas, M. Bolze, P.A. Lavoué, V. Gauthier, T. Graesslin, O. Fauconnier, A. Huchon, C. |
| description | Vulvar cancer is a rare pathology affecting mainly elderly women. This study aims to evaluate the impact of age on tumor size in vulvar cancer.
This was a multicenter retrospective observational study carried out between January 1, 1998, and December 31, 2020, in patients operated on for vulvar cancer. Univariate analysis was performed according to patients' age ≥ or |
| doi_str_mv | 10.1016/j.ejso.2024.108482 |
| format | Article |
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This was a multicenter retrospective observational study carried out between January 1, 1998, and December 31, 2020, in patients operated on for vulvar cancer. Univariate analysis was performed according to patients' age ≥ or <65 years. Factors associated with tumor size found to be significant according to age were then included in a multiple linear regression model.
Of the 382 patients included, there were 133 patients aged <65 years and 249 ≥ 65 years. Radical total vulvectomy surgeries were more frequently performed in women ≥65 years (n = 72 (28.9 %) versus n = 20 (15 %); p = 0.004). The median histological tumor size and interquartile range was 20 mm [13–29] in the <65 years and 30 mm [15–42] in patients ≥65 years (p = 0.001). Multiple linear regression showed that age ≥65 years had a regression coefficient of 7.15 95 % CI [2.32; 11.99] (p = 0.004), constituting a risk factor for larger histological tumour size. Patients aged ≥65 years old had a higher early complication rate (n = 150 (62 %) versus n = 56 (42.7 %), p = 0.001). They also had a greater risk of recurrence (HR = 1.89 (95%CI (1.24–2.89)), p = 0.003) with a worse overall survival (HR = 5.64 (95%CI (1.70–18.68)), p = 0.005).
Age is a risk factor for larger tumor size, leading to more radical surgery and a greater risk of complications in already fragile patients, with a greater risk of recurrence and an impact on overall survival.</description><identifier>ISSN: 0748-7983</identifier><identifier>ISSN: 1532-2157</identifier><identifier>EISSN: 1532-2157</identifier><identifier>DOI: 10.1016/j.ejso.2024.108482</identifier><identifier>PMID: 38901290</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Age ; Age Factors ; Aged ; Aged, 80 and over ; Cancer ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; Female ; France - epidemiology ; Humans ; Life Sciences ; Middle Aged ; Retrospective Studies ; Survival Rate ; Tumor Burden ; Tumor size ; Vulvar cancer ; Vulvar Neoplasms - pathology ; Vulvar Neoplasms - surgery ; Vulvectomy</subject><ispartof>European journal of surgical oncology, 2024-09, Vol.50 (9), p.108482, Article 108482</ispartof><rights>2024 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology</rights><rights>Copyright © 2024 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c271t-bda07dee42d13be25b97dc6109eeae30eeb8cb4bb708c1d813cc1c53d9e393c83</cites><orcidid>0000-0002-4988-9723 ; 0000-0002-4682-2806 ; 0000-0002-5957-4768 ; 0000-0003-2860-5450 ; 0000-0002-9688-0385 ; 0000-0002-9533-3558</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0748798324005341$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38901290$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://amu.hal.science/hal-04689357$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Raimond, E.</creatorcontrib><creatorcontrib>Kerbage, Y.</creatorcontrib><creatorcontrib>Ouldamer, L.</creatorcontrib><creatorcontrib>Bendifallah, S.</creatorcontrib><creatorcontrib>Carcopino, X.</creatorcontrib><creatorcontrib>Koskas, M.</creatorcontrib><creatorcontrib>Bolze, P.A.</creatorcontrib><creatorcontrib>Lavoué, V.</creatorcontrib><creatorcontrib>Gauthier, T.</creatorcontrib><creatorcontrib>Graesslin, O.</creatorcontrib><creatorcontrib>Fauconnier, A.</creatorcontrib><creatorcontrib>Huchon, C.</creatorcontrib><title>Impact of age on tumor size in vulvar cancer: A multicenter study by the Francogyn group</title><title>European journal of surgical oncology</title><addtitle>Eur J Surg Oncol</addtitle><description>Vulvar cancer is a rare pathology affecting mainly elderly women. This study aims to evaluate the impact of age on tumor size in vulvar cancer.
This was a multicenter retrospective observational study carried out between January 1, 1998, and December 31, 2020, in patients operated on for vulvar cancer. Univariate analysis was performed according to patients' age ≥ or <65 years. Factors associated with tumor size found to be significant according to age were then included in a multiple linear regression model.
Of the 382 patients included, there were 133 patients aged <65 years and 249 ≥ 65 years. Radical total vulvectomy surgeries were more frequently performed in women ≥65 years (n = 72 (28.9 %) versus n = 20 (15 %); p = 0.004). The median histological tumor size and interquartile range was 20 mm [13–29] in the <65 years and 30 mm [15–42] in patients ≥65 years (p = 0.001). Multiple linear regression showed that age ≥65 years had a regression coefficient of 7.15 95 % CI [2.32; 11.99] (p = 0.004), constituting a risk factor for larger histological tumour size. Patients aged ≥65 years old had a higher early complication rate (n = 150 (62 %) versus n = 56 (42.7 %), p = 0.001). They also had a greater risk of recurrence (HR = 1.89 (95%CI (1.24–2.89)), p = 0.003) with a worse overall survival (HR = 5.64 (95%CI (1.70–18.68)), p = 0.005).
Age is a risk factor for larger tumor size, leading to more radical surgery and a greater risk of complications in already fragile patients, with a greater risk of recurrence and an impact on overall survival.</description><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cancer</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Female</subject><subject>France - epidemiology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Tumor Burden</subject><subject>Tumor size</subject><subject>Vulvar cancer</subject><subject>Vulvar Neoplasms - pathology</subject><subject>Vulvar Neoplasms - surgery</subject><subject>Vulvectomy</subject><issn>0748-7983</issn><issn>1532-2157</issn><issn>1532-2157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEuLFDEUhYMoTjv6B1xIlrqoNo-qTiJumsFxBhrcKLgLedzuSVNVaZNUQ8-vN0WNs3R14fCdc-FD6D0la0ro5vNxDccc14ywtgaylewFWtGOs4bRTrxEKyJa2Qgl-RV6k_OREKK4UK_RFZeKUKbICv2-H07GFRz32BwAxxGXaYgJ5_AIOIz4PPVnk7Azo4P0BW_xMPUlOBgLVKhM_oLtBZcHwLepMvFwGfEhxen0Fr3amz7Du6d7jX7dfvt5c9fsfny_v9nuGscELY31hggP0DJPuQXWWSW821CiAAxwAmCls621gkhHvaTcOeo67hVwxZ3k1-jTsvtgen1KYTDpoqMJ-m6703NG2o1UvBNnWtmPC3tK8c8EueghZAd9b0aIU9ac1C9cdHJG2YK6FHNOsH_epkTP9vVRz_b1bF8v9mvpw9P-ZAfwz5V_uivwdQGgGjkHSDq7AFWtDwlc0T6G_-3_BU7Rlcw</recordid><startdate>202409</startdate><enddate>202409</enddate><creator>Raimond, E.</creator><creator>Kerbage, Y.</creator><creator>Ouldamer, L.</creator><creator>Bendifallah, S.</creator><creator>Carcopino, X.</creator><creator>Koskas, M.</creator><creator>Bolze, P.A.</creator><creator>Lavoué, V.</creator><creator>Gauthier, T.</creator><creator>Graesslin, O.</creator><creator>Fauconnier, A.</creator><creator>Huchon, C.</creator><general>Elsevier Ltd</general><general>WB Saunders</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-4988-9723</orcidid><orcidid>https://orcid.org/0000-0002-4682-2806</orcidid><orcidid>https://orcid.org/0000-0002-5957-4768</orcidid><orcidid>https://orcid.org/0000-0003-2860-5450</orcidid><orcidid>https://orcid.org/0000-0002-9688-0385</orcidid><orcidid>https://orcid.org/0000-0002-9533-3558</orcidid></search><sort><creationdate>202409</creationdate><title>Impact of age on tumor size in vulvar cancer: A multicenter study by the Francogyn group</title><author>Raimond, E. ; Kerbage, Y. ; Ouldamer, L. ; Bendifallah, S. ; Carcopino, X. ; Koskas, M. ; Bolze, P.A. ; Lavoué, V. ; Gauthier, T. ; Graesslin, O. ; Fauconnier, A. ; Huchon, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c271t-bda07dee42d13be25b97dc6109eeae30eeb8cb4bb708c1d813cc1c53d9e393c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cancer</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Female</topic><topic>France - epidemiology</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>Tumor Burden</topic><topic>Tumor size</topic><topic>Vulvar cancer</topic><topic>Vulvar Neoplasms - pathology</topic><topic>Vulvar Neoplasms - surgery</topic><topic>Vulvectomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raimond, E.</creatorcontrib><creatorcontrib>Kerbage, Y.</creatorcontrib><creatorcontrib>Ouldamer, L.</creatorcontrib><creatorcontrib>Bendifallah, S.</creatorcontrib><creatorcontrib>Carcopino, X.</creatorcontrib><creatorcontrib>Koskas, M.</creatorcontrib><creatorcontrib>Bolze, P.A.</creatorcontrib><creatorcontrib>Lavoué, V.</creatorcontrib><creatorcontrib>Gauthier, T.</creatorcontrib><creatorcontrib>Graesslin, O.</creatorcontrib><creatorcontrib>Fauconnier, A.</creatorcontrib><creatorcontrib>Huchon, C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>European journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raimond, E.</au><au>Kerbage, Y.</au><au>Ouldamer, L.</au><au>Bendifallah, S.</au><au>Carcopino, X.</au><au>Koskas, M.</au><au>Bolze, P.A.</au><au>Lavoué, V.</au><au>Gauthier, T.</au><au>Graesslin, O.</au><au>Fauconnier, A.</au><au>Huchon, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of age on tumor size in vulvar cancer: A multicenter study by the Francogyn group</atitle><jtitle>European journal of surgical oncology</jtitle><addtitle>Eur J Surg Oncol</addtitle><date>2024-09</date><risdate>2024</risdate><volume>50</volume><issue>9</issue><spage>108482</spage><pages>108482-</pages><artnum>108482</artnum><issn>0748-7983</issn><issn>1532-2157</issn><eissn>1532-2157</eissn><abstract>Vulvar cancer is a rare pathology affecting mainly elderly women. This study aims to evaluate the impact of age on tumor size in vulvar cancer.
This was a multicenter retrospective observational study carried out between January 1, 1998, and December 31, 2020, in patients operated on for vulvar cancer. Univariate analysis was performed according to patients' age ≥ or <65 years. Factors associated with tumor size found to be significant according to age were then included in a multiple linear regression model.
Of the 382 patients included, there were 133 patients aged <65 years and 249 ≥ 65 years. Radical total vulvectomy surgeries were more frequently performed in women ≥65 years (n = 72 (28.9 %) versus n = 20 (15 %); p = 0.004). The median histological tumor size and interquartile range was 20 mm [13–29] in the <65 years and 30 mm [15–42] in patients ≥65 years (p = 0.001). Multiple linear regression showed that age ≥65 years had a regression coefficient of 7.15 95 % CI [2.32; 11.99] (p = 0.004), constituting a risk factor for larger histological tumour size. Patients aged ≥65 years old had a higher early complication rate (n = 150 (62 %) versus n = 56 (42.7 %), p = 0.001). They also had a greater risk of recurrence (HR = 1.89 (95%CI (1.24–2.89)), p = 0.003) with a worse overall survival (HR = 5.64 (95%CI (1.70–18.68)), p = 0.005).
Age is a risk factor for larger tumor size, leading to more radical surgery and a greater risk of complications in already fragile patients, with a greater risk of recurrence and an impact on overall survival.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>38901290</pmid><doi>10.1016/j.ejso.2024.108482</doi><orcidid>https://orcid.org/0000-0002-4988-9723</orcidid><orcidid>https://orcid.org/0000-0002-4682-2806</orcidid><orcidid>https://orcid.org/0000-0002-5957-4768</orcidid><orcidid>https://orcid.org/0000-0003-2860-5450</orcidid><orcidid>https://orcid.org/0000-0002-9688-0385</orcidid><orcidid>https://orcid.org/0000-0002-9533-3558</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of surgical oncology, 2024-09, Vol.50 (9), p.108482, Article 108482 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Age Age Factors Aged Aged, 80 and over Cancer Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery Female France - epidemiology Humans Life Sciences Middle Aged Retrospective Studies Survival Rate Tumor Burden Tumor size Vulvar cancer Vulvar Neoplasms - pathology Vulvar Neoplasms - surgery Vulvectomy |
| title | Impact of age on tumor size in vulvar cancer: A multicenter study by the Francogyn group |
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