Proteolytic bacteria expansion during colitis amplifies inflammation through cleavage of the external domain of PAR2

Imbalances in proteolytic activity have been linked to the development of inflammatory bowel diseases (IBD) and experimental colitis. Proteases in the intestine play important roles in maintaining homeostasis, but exposure of mucosal tissues to excess proteolytic activity can promote pathology throu...

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Veröffentlicht in:	Gut microbes 2024-12, Vol.16 (1), p.2387857
Hauptverfasser:	Rondeau, Liam Emile, Da Luz, Bruna Barbosa, Santiago, Alba, Bermudez-Brito, Miriam, Hann, Amber, De Palma, Giada, Jury, Jennifer, Wang, Xuanyu, Verdu, Elena Francisca, Galipeau, Heather Jean, Rolland, Corinne, Deraison, Celine, Ruf, Wolfram, Bercik, Premysl, Vergnolle, Nathalie, Caminero, Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria - classification Bacteria - enzymology Bacteria - genetics Bacteria - metabolism colitis Colitis - metabolism Colitis - microbiology Colitis - pathology Disease Models, Animal DSS-induced colitis Endocrinology and metabolism Enterococcus - genetics Enterococcus - metabolism Food and Nutrition Gastrointestinal Microbiome gnotobiotic mice Human health and pathology Humans inflammation Inflammation - metabolism Inflammation - microbiology Inflammatory bowel disease Inflammatory Bowel Diseases - metabolism Inflammatory Bowel Diseases - microbiology Inflammatory Bowel Diseases - pathology Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Intestinal Mucosa - pathology Life Sciences Mice Mice, Inbred C57BL microbiota protease-activated receptor 2 (PAR2) proteases Protein Domains Proteolysis proteolytic activity Receptor, PAR-2 - genetics Receptor, PAR-2 - metabolism Research Paper
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