Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis
Axon outgrowth during development and neurotransmitter release depends on exocytotic mechanisms, although what protein machinery is common to or differentiates these processes remains unclear. Here we show that the neural t-SNARE (target-membrane-associated–soluble N-ethylmaleimide fusion protein at...
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| Veröffentlicht in: | Nature neuroscience 2002-01, Vol.5 (1), p.19-26 |
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| creator | Washbourne, Philip Thompson, Peter M. Carta, Mario Costa, Edmar T. Mathews, James R. Lopez-Benditó, Guillermina Molnár, Zoltán Becher, Mark W. Valenzuela, C. Fernando Partridge, L. Donald Wilson, Michael C. |
| description | Axon outgrowth during development and neurotransmitter release depends on exocytotic mechanisms, although what protein machinery is common to or differentiates these processes remains unclear. Here we show that the neural t-SNARE (target-membrane-associated–soluble N-ethylmaleimide fusion protein attachment protein (SNAP) receptor) SNAP-25 is not required for nerve growth or stimulus-independent neurotransmitter release, but is essential for evoked synaptic transmission at neuromuscular junctions and central synapses. These results demonstrate that the development of neurotransmission requires the recruitment of a specialized SNARE core complex to meet the demands of regulated exocytosis. |
| doi_str_mv | 10.1038/nn783 |
| format | Article |
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Fernando</creatorcontrib><creatorcontrib>Partridge, L. Donald</creatorcontrib><creatorcontrib>Wilson, Michael C.</creatorcontrib><title>Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis</title><title>Nature neuroscience</title><addtitle>Nat Neurosci</addtitle><addtitle>Nat Neurosci</addtitle><description>Axon outgrowth during development and neurotransmitter release depends on exocytotic mechanisms, although what protein machinery is common to or differentiates these processes remains unclear. Here we show that the neural t-SNARE (target-membrane-associated–soluble N-ethylmaleimide fusion protein attachment protein (SNAP) receptor) SNAP-25 is not required for nerve growth or stimulus-independent neurotransmitter release, but is essential for evoked synaptic transmission at neuromuscular junctions and central synapses. 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Fernando</au><au>Partridge, L. Donald</au><au>Wilson, Michael C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis</atitle><jtitle>Nature neuroscience</jtitle><stitle>Nat Neurosci</stitle><addtitle>Nat Neurosci</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>5</volume><issue>1</issue><spage>19</spage><epage>26</epage><pages>19-26</pages><issn>1097-6256</issn><eissn>1546-1726</eissn><coden>NANEFN</coden><abstract>Axon outgrowth during development and neurotransmitter release depends on exocytotic mechanisms, although what protein machinery is common to or differentiates these processes remains unclear. Here we show that the neural t-SNARE (target-membrane-associated–soluble N-ethylmaleimide fusion protein attachment protein (SNAP) receptor) SNAP-25 is not required for nerve growth or stimulus-independent neurotransmitter release, but is essential for evoked synaptic transmission at neuromuscular junctions and central synapses. These results demonstrate that the development of neurotransmission requires the recruitment of a specialized SNARE core complex to meet the demands of regulated exocytosis.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>11753414</pmid><doi>10.1038/nn783</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Brain - cytology Brain - embryology Brain - metabolism Cells, Cultured Dermis - cytology Dermis - metabolism Diaphragm - metabolism Embryo, Mammalian - physiology Embryonic and Fetal Development Exocytosis Exocytosis - physiology Gene therapy Health aspects Immunohistochemistry In Vitro Techniques Life Sciences Membrane Proteins - genetics Membrane Proteins - metabolism Methods Mice Mice, Knockout Muscle, Skeletal - cytology Muscle, Skeletal - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurobiology Neuromuscular Junction - physiology Neurons - physiology Neurons - ultrastructure Neurosciences Neurotransmitter receptors Patch-Clamp Techniques Physiological aspects SNARE complex SNARE Proteins Synaptic Transmission - physiology Synaptosomal-Associated Protein 25 Vesicular Transport Proteins |
| title | Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis |
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