Online identification of pharmacodynamic parameters for closed-loop anesthesia with model predictive control

In this paper, a controller is proposed to automate the injection of propofol and remifentanil during general anesthesia using bispectral index (BIS) measurement. To handle the parameter uncertainties due to inter- and intra-patient variability, an extended estimator is used coupled with a Model Pre...

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Veröffentlicht in:	Computers & chemical engineering 2024-12, Vol.191, p.108837, Article 108837
Hauptverfasser:	Aubouin–Pairault, Bob, Fiacchini, Mirko, Dang, Thao
Format:	Artikel
Sprache:	eng
Schlagworte:	Automatic Control Engineering Bioengineering Closed-loop anesthesia Computer Science Drug control Life Sciences Model predictive control Moving horizon estimator Multi-Kalman filters Pharmaceutical sciences Uncertain systems
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