The angiogenic growth factor and biomarker midkine is a tumor-shared antigen

The angiogenic factor Midkine (MDK) is overexpressed in various human malignant tumors, although its expression is low or undetectable in normal adult tissues. Its expression in tumors and its detection in plasma have been associated with poor disease outcome, whereas its blockade was found to contr...

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Veröffentlicht in:	The Journal of immunology (1950) 2010-07, Vol.185 (1), p.418-423
Hauptverfasser:	Kerzerho, Jerome, Adotevi, Olivier, Castelli, Florence A, Dosset, Magalie, Bernardeau, Karine, Szely, Natacha, Lang, Francois, Tartour, Eric, Maillere, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Angiogenic Proteins - biosynthesis Angiogenic Proteins - physiology Angiogenic Proteins - secretion Animals Antigen Presentation - genetics Antigen Presentation - immunology Antigens, Neoplasm - biosynthesis Antigens, Neoplasm - genetics Antigens, Neoplasm - physiology Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - physiology Biomarkers, Tumor - secretion Cell Line, Tumor Cytotoxicity Tests, Immunologic - methods Epitopes, T-Lymphocyte - biosynthesis Epitopes, T-Lymphocyte - genetics Epitopes, T-Lymphocyte - physiology Female HLA-A Antigens - genetics HLA-A2 Antigen - genetics Humans Life Sciences Melanoma, Experimental - genetics Melanoma, Experimental - immunology Melanoma, Experimental - therapy Mice Mice, Transgenic Nerve Growth Factors - biosynthesis Nerve Growth Factors - physiology Nerve Growth Factors - secretion T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism T-Lymphocytes, Cytotoxic - secretion
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