Effect of wortmannin, an inhibitor of phosphatidylinositol 3-kinase, on the first mitotic divisions of the fertilized sea urchin egg

We have reported earlier that the polyphosphoinositide messenger system may control mitosis in sea urchin eggs. Besides phospholipase C activation and its second messengers, phosphatidylinositol (PI) 3-kinase has been proposed to affect a wide variety of cellular processes in other cellular systems....

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Veröffentlicht in:	Journal of cell science 1998-09, Vol.111 ( Pt 17) (17), p.2507-2518
Hauptverfasser:	De Nadai, C, Huitorel, P, Chiri, S, Ciapa, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes Androstadienes - pharmacology Animals Cell Cycle Cell Cycle - drug effects Cell Division Cell Division - drug effects DNA DNA - biosynthesis Enzyme Activation Life Sciences Maturation-Promoting Factor Maturation-Promoting Factor - analysis Maturation-Promoting Factor - metabolism Mitosis Mitosis - drug effects Mycotoxins Nuclear Envelope Nuclear Envelope - metabolism Phosphatidylinositol 3-Kinases Phosphatidylinositol 3-Kinases - analysis Phosphoinositide-3 Kinase Inhibitors Phospholipases A Phospholipases A - antagonists & inhibitors Phosphorylation Phosphorylation - drug effects Proteins Proteins - metabolism Sea Urchins Spindle Apparatus Spindle Apparatus - drug effects Wortmannin Zygote Zygote - cytology Zygote - drug effects Zygote - enzymology
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