CD38/NAD+ glycohydrolase and associated antigens in chronic lymphocytic leukaemia: From interconnected signalling pathways to therapeutic strategies

Chronic lymphocytic leukaemia (CLL) is a heterogenous disease characterized by the accumulation of neoplastic CD5+/CD19+ B lymphocytes. The spreading of the leukaemia relies on the CLL cell's ability to survive in the blood and migrate to and proliferate within the bone marrow and lymphoid tiss...

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Veröffentlicht in:	Biochimie 2024-12, Vol.227 (Pt A), p.135-151
Hauptverfasser:	Bauvois, Brigitte, Nguyen-Khac, Florence, Merle-Béral, Hélène, Susin, Santos A.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-ribosyl Cyclase 1 - immunology ADP-ribosyl Cyclase 1 - metabolism Animals Antibody antigens Antigens, Neoplasm - immunology Antigens, Neoplasm - metabolism B-lymphocytes BCR bone marrow CD38 CD44 cell viability chemokine receptors CLL CXCR4 drug resistance Function Humans integrins leukemia Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - immunology Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Life Sciences Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism neutrophils pathophysiology prognosis relapse Signal Transduction Signaling therapeutics vascular endothelial growth factor receptor-2 VEGF-R2 VLA4
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