Bioactive peptides from yeast: A comparative review on production methods, bioactivity, structure-function relationship, and stability

Yeast cells are a rich source of protein and have long been investigated for the production of yeast extract as a source of bioactive peptides with different documented bioactivity, e.g. antioxidant, ACE-inhibitory, antidiabetic, as well as prevention of chronic diseases and providing immune responc...

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Veröffentlicht in:Trends in food science & technology 2021-12, Vol.118 (Part A), p.297-315
Hauptverfasser: Mirzaei, Mahta, Shavandi, Amin, Mirdamadi, Saeed, Soleymanzadeh, Nazila, Motahari, Paria, Mirdamadi, Niloofar, Moser, Muriel, Subra, Gilles, Alimoradi, Houman, Goriely, Stanislas
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container_issue Part A
container_start_page 297
container_title Trends in food science & technology
container_volume 118
creator Mirzaei, Mahta
Shavandi, Amin
Mirdamadi, Saeed
Soleymanzadeh, Nazila
Motahari, Paria
Mirdamadi, Niloofar
Moser, Muriel
Subra, Gilles
Alimoradi, Houman
Goriely, Stanislas
description Yeast cells are a rich source of protein and have long been investigated for the production of yeast extract as a source of bioactive peptides with different documented bioactivity, e.g. antioxidant, ACE-inhibitory, antidiabetic, as well as prevention of chronic diseases and providing immune responces. Furthermore, yeast cells are known to contribute to generation of bioactive peptides due to their proteolytic activity during fermentation processes, and also release of antimicrobial peptides during growth. Although reports on preparation and characteristic of yeast extract increased tremendously, research on the functional properties of yeast extract attributed to the content of bioactive peptides and production methods lack a systematic review. Also, the contribution of yeast cells to the production of bioactive peptides during the growth and fermentation process has not been summarized previously. This review summarizes previous studies on yeast-derived peptides, the production methods, the bioactivity, the mechanism of action, as well as the structure-function relationship, and stability of identified peptides. This article would be helpful to promote the application of yeast-derived peptides in research and commercialization. Yeast cells and yeast extract have great potentials for producing bioactive peptides with multiple functionalities. Current scientific evidence regarding the potential health benefit of yeast highlights the need for additional investigation on the bioactivity of peptides as influenced by production and purification methods. Also, predicting and designing new peptide sequences with specific functionality with the aid of bioinformatics tools, animal and human studies will effectively transfer these findings into practical and market applications. •Yeast extract is a source of bioactive peptides under the influence of production method.•The proteolytic activity of yeast leads to production of peptides in fermented foods.•Yeast cells are capable of releasing antimicrobial peptides.•Antioxidant, ACE-inhibitory, and antimicrobial activity are mostly reported for yeast derived peptides.
doi_str_mv 10.1016/j.tifs.2021.10.008
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subjects Antiinfectives and antibacterials
Antimicrobial peptides
Antioxidants
Bioactive peptides
Bioinformatics
Biological activity
Chronic illnesses
Commercialization
Diabetes mellitus
Enzymatic hydrolysis
Fermentation
Food engineering
Life Sciences
Peptides
Production methods
Protein purification
Protein sources
Proteolysis
Reviews
Structural stability
Structure-function relationships
Yeast
Yeast cells
Yeast extract
Yeasts
title Bioactive peptides from yeast: A comparative review on production methods, bioactivity, structure-function relationship, and stability
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