All‐trans retinoic acid exhibits anti‐proliferative and differentiating activity in Merkel cell carcinoma cells via retinoid pathway modulation

Background The limited therapies available for treating Merkel cell carcinoma (MCC), a highly aggressive skin neoplasm, still pose clinical challenges, and novel treatments are required. Targeting retinoid signalling with retinoids, such as all‐trans retinoic acid (ATRA), is a promising and clinical...

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Veröffentlicht in:	Journal of the European Academy of Dermatology and Venereology 2024-07, Vol.38 (7), p.1419-1431
Hauptverfasser:	Mazziotta, Chiara, Badiale, Giada, Cervellera, Christian Felice, Morciano, Giampaolo, Di Mauro, Giulia, Touzé, Antoine, Pinton, Paolo, Tognon, Mauro, Martini, Fernanda, Rotondo, John Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis - drug effects Carcinoma, Merkel Cell - drug therapy Carcinoma, Merkel Cell - metabolism Carcinoma, Merkel Cell - pathology Cell Differentiation - drug effects Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cell Survival - drug effects Dermatology Human health and pathology Humans Life Sciences Microbiology and Parasitology Retinoids - pharmacology Retinoids - therapeutic use Signal Transduction - drug effects Skin Neoplasms - drug therapy Skin Neoplasms - metabolism Skin Neoplasms - pathology Tretinoin - pharmacology Tretinoin - therapeutic use Virology
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