Binding of Factor VIIa to Tissue Factor on Keratinocytes Induces Gene Expression

Binding of the zymogen serine protease Factor VII (FVII) to its cellular cofactor tissue factor (TF) triggers blood coagulation. Several recent reports have suggested that the formation of this complex may serve additional functions. We have used cDNA arrays to study differential gene expression in...

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Veröffentlicht in:	The Journal of biological chemistry 2000-03, Vol.275 (9), p.6580-6585
Hauptverfasser:	Camerer, Eric, Gjernes, Elisabet, Wiiger, Merete, Pringle, Serena, Prydz, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies - pharmacology Cell Line factor VII Factor VIIa - metabolism Gene Expression Regulation - genetics Hirudins - pharmacology Humans Keratinocytes - metabolism Life Sciences Protein Binding RNA, Messenger - metabolism serine proteinase Thromboplastin - immunology Thromboplastin - metabolism Up-Regulation - genetics
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