Ex vivo study on ATPase activities of rabbit renal proximal tubules as a predictive model for nephrotoxicity: Comparison with an in vitro study on a new cephalosporin (cefpirome)
An ex vivo study on adenosine triphosphatase (ATPase) activities of rabbit renal proximal tubules was conducted with a new cephalosporin, cefpirome (HR 810), a positive control, cephaloridine, and a reference third-generation cephalosporin, cefotaxime. Compared with controls, CPH caused a significan...
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| Veröffentlicht in: | Toxicology in vitro 1994-10, Vol.8 (5), p.1091-1096 |
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| container_title | Toxicology in vitro |
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| creator | Dutertre-Catella, H. Martin, C. Olivier, M.F. Thevenin, M. Warnet, J.-M. Vannier, B. Claude, J.-R. Podevins, R.A. |
| description | An
ex vivo study on adenosine triphosphatase (ATPase) activities of rabbit renal proximal tubules was conducted with a new cephalosporin, cefpirome (HR 810), a positive control, cephaloridine, and a reference third-generation cephalosporin, cefotaxime. Compared with controls, CPH caused a significant time-dependent decrease in ATPase activities [12%, 2 hr after treatment (
P < 0.01) and 75%, 48 hr after treatment (
P < 0.001)]. This decrease was accompanied by a significant loss in the energy charge of the adenylate pool [27%, 2 hr after treatment (
P < 0.001)]. Neither cefotaxime nor cefpirome caused such decreases. The results confirmed those of a previously published
in vitro study. The advantages and disadvantages of these two experimental procedures as predictive models for nephrotoxicity are discussed. |
| doi_str_mv | 10.1016/0887-2333(94)90249-6 |
| format | Article |
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ex vivo study on adenosine triphosphatase (ATPase) activities of rabbit renal proximal tubules was conducted with a new cephalosporin, cefpirome (HR 810), a positive control, cephaloridine, and a reference third-generation cephalosporin, cefotaxime. Compared with controls, CPH caused a significant time-dependent decrease in ATPase activities [12%, 2 hr after treatment (
P < 0.01) and 75%, 48 hr after treatment (
P < 0.001)]. This decrease was accompanied by a significant loss in the energy charge of the adenylate pool [27%, 2 hr after treatment (
P < 0.001)]. Neither cefotaxime nor cefpirome caused such decreases. The results confirmed those of a previously published
in vitro study. The advantages and disadvantages of these two experimental procedures as predictive models for nephrotoxicity are discussed.</description><identifier>ISSN: 0887-2333</identifier><identifier>EISSN: 1879-3177</identifier><identifier>DOI: 10.1016/0887-2333(94)90249-6</identifier><identifier>PMID: 20693076</identifier><identifier>CODEN: TIVIEQ</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Biological and medical sciences ; Drug toxicity and drugs side effects treatment ; Genetics ; Human genetics ; Life Sciences ; Medical sciences ; Pharmacology. Drug treatments ; Toxicity: urogenital system</subject><ispartof>Toxicology in vitro, 1994-10, Vol.8 (5), p.1091-1096</ispartof><rights>1994</rights><rights>1995 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c402t-8b60305a98845d3ebac705ef93f52fcb8a0c8934107befcca4f4e0e7a3c373c53</cites><orcidid>0000-0002-6870-507X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0887233394902496$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3321257$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20693076$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04618581$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Dutertre-Catella, H.</creatorcontrib><creatorcontrib>Martin, C.</creatorcontrib><creatorcontrib>Olivier, M.F.</creatorcontrib><creatorcontrib>Thevenin, M.</creatorcontrib><creatorcontrib>Warnet, J.-M.</creatorcontrib><creatorcontrib>Vannier, B.</creatorcontrib><creatorcontrib>Claude, J.-R.</creatorcontrib><creatorcontrib>Podevins, R.A.</creatorcontrib><title>Ex vivo study on ATPase activities of rabbit renal proximal tubules as a predictive model for nephrotoxicity: Comparison with an in vitro study on a new cephalosporin (cefpirome)</title><title>Toxicology in vitro</title><addtitle>Toxicol In Vitro</addtitle><description>An
ex vivo study on adenosine triphosphatase (ATPase) activities of rabbit renal proximal tubules was conducted with a new cephalosporin, cefpirome (HR 810), a positive control, cephaloridine, and a reference third-generation cephalosporin, cefotaxime. Compared with controls, CPH caused a significant time-dependent decrease in ATPase activities [12%, 2 hr after treatment (
P < 0.01) and 75%, 48 hr after treatment (
P < 0.001)]. This decrease was accompanied by a significant loss in the energy charge of the adenylate pool [27%, 2 hr after treatment (
P < 0.001)]. Neither cefotaxime nor cefpirome caused such decreases. The results confirmed those of a previously published
in vitro study. The advantages and disadvantages of these two experimental procedures as predictive models for nephrotoxicity are discussed.</description><subject>Biological and medical sciences</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Genetics</subject><subject>Human genetics</subject><subject>Life Sciences</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Toxicity: urogenital system</subject><issn>0887-2333</issn><issn>1879-3177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNp9ktGK1DAUhoso7jj6BiK5EN25qCZN0qR7IQzD6goDerFehzQ9YSNtU5N0due1fEIzzjh4tRBIOHx_8uf8pyheE_yBYFJ_xFKKsqKUXjZs1eCKNWX9pFgQKZqSEiGeFoszclG8iPEnxpjLCj8vLipcNxSLelH8vn5AO7fzKKa52yM_ovXtdx0BaZPcziUHEXmLgm5bl1CAUfdoCv7BDfmQ5nbuM6DzylXo3EEEaPAd9Mj6gEaY7oJPmTcu7a_Qxg-TDi7md-5dukN6RG7MBlL4z4HOsntkslT3Pk4-ZOTSgJ1c8AOsXhbPrO4jvDrty-LH5-vbzU25_fbl62a9LQ3DVSplW2OKuW6kZLyj0GojMAfbUMsra1qpsZENZQSLFqwxmlkGGISmhgpqOF0Wq-O92YaaQv5x2CuvnbpZb9WhhllNJJdkRzL7_sjm3vyaISY1uGig7_UIfo5KsJxQU-colsW7R0lS15xzgTPIjqAJPsYA9uyBYHWYAHWIVx3iVQ1TfydA1Vn25nT_3A7QnUX_Is_A2xOgo9G9DXo0Lp45SitScZGxT0cMcot3DoKKxsFocsgBTFKdd48b-QN2IM9D</recordid><startdate>19941001</startdate><enddate>19941001</enddate><creator>Dutertre-Catella, H.</creator><creator>Martin, C.</creator><creator>Olivier, M.F.</creator><creator>Thevenin, M.</creator><creator>Warnet, J.-M.</creator><creator>Vannier, B.</creator><creator>Claude, J.-R.</creator><creator>Podevins, R.A.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><general>Elsevier</general><scope>IQODW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-6870-507X</orcidid></search><sort><creationdate>19941001</creationdate><title>Ex vivo study on ATPase activities of rabbit renal proximal tubules as a predictive model for nephrotoxicity: Comparison with an in vitro study on a new cephalosporin (cefpirome)</title><author>Dutertre-Catella, H. ; Martin, C. ; Olivier, M.F. ; Thevenin, M. ; Warnet, J.-M. ; Vannier, B. ; Claude, J.-R. ; Podevins, R.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-8b60305a98845d3ebac705ef93f52fcb8a0c8934107befcca4f4e0e7a3c373c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Biological and medical sciences</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Genetics</topic><topic>Human genetics</topic><topic>Life Sciences</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Toxicity: urogenital system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dutertre-Catella, H.</creatorcontrib><creatorcontrib>Martin, C.</creatorcontrib><creatorcontrib>Olivier, M.F.</creatorcontrib><creatorcontrib>Thevenin, M.</creatorcontrib><creatorcontrib>Warnet, J.-M.</creatorcontrib><creatorcontrib>Vannier, B.</creatorcontrib><creatorcontrib>Claude, J.-R.</creatorcontrib><creatorcontrib>Podevins, R.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Toxicology in vitro</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dutertre-Catella, H.</au><au>Martin, C.</au><au>Olivier, M.F.</au><au>Thevenin, M.</au><au>Warnet, J.-M.</au><au>Vannier, B.</au><au>Claude, J.-R.</au><au>Podevins, R.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ex vivo study on ATPase activities of rabbit renal proximal tubules as a predictive model for nephrotoxicity: Comparison with an in vitro study on a new cephalosporin (cefpirome)</atitle><jtitle>Toxicology in vitro</jtitle><addtitle>Toxicol In Vitro</addtitle><date>1994-10-01</date><risdate>1994</risdate><volume>8</volume><issue>5</issue><spage>1091</spage><epage>1096</epage><pages>1091-1096</pages><issn>0887-2333</issn><eissn>1879-3177</eissn><coden>TIVIEQ</coden><abstract>An
ex vivo study on adenosine triphosphatase (ATPase) activities of rabbit renal proximal tubules was conducted with a new cephalosporin, cefpirome (HR 810), a positive control, cephaloridine, and a reference third-generation cephalosporin, cefotaxime. Compared with controls, CPH caused a significant time-dependent decrease in ATPase activities [12%, 2 hr after treatment (
P < 0.01) and 75%, 48 hr after treatment (
P < 0.001)]. This decrease was accompanied by a significant loss in the energy charge of the adenylate pool [27%, 2 hr after treatment (
P < 0.001)]. Neither cefotaxime nor cefpirome caused such decreases. The results confirmed those of a previously published
in vitro study. The advantages and disadvantages of these two experimental procedures as predictive models for nephrotoxicity are discussed.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>20693076</pmid><doi>10.1016/0887-2333(94)90249-6</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-6870-507X</orcidid></addata></record> |
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| source | Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Drug toxicity and drugs side effects treatment Genetics Human genetics Life Sciences Medical sciences Pharmacology. Drug treatments Toxicity: urogenital system |
| title | Ex vivo study on ATPase activities of rabbit renal proximal tubules as a predictive model for nephrotoxicity: Comparison with an in vitro study on a new cephalosporin (cefpirome) |
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