Hydrazone analogs as DNA gyrase inhibitors and antioxidant agents: Structure-activity relationship and pharmacophore modeling

In this paper, we report the synthesis and the structure–activity relationship study of three hydrazone analogs; the Schiff base hydrazone SBH and 2, 4-dinitrophenylhydrazones H1 & H2 derived from ( E )-chalcones, to identify the active fragment of each structure. This identification has been ca...

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Veröffentlicht in:	Journal of Chemical Sciences 2024-05, Vol.136 (2), Article 32
Hauptverfasser:	Dammene Debbih, Ouafa, Mazouz, Wissam, Benslama, Ouided, Zouchoune, Bachir, Selatnia, Ilhem, Bouchene, Rafika, Sid, Assia, Bouacida, Sofiane, Mosset, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical Sciences Chemistry Chemistry and Materials Science Chemistry/Food Science Medicinal Chemistry Regular Article
Online-Zugang:	Volltext
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