Molecular allergology: a clinical laboratory tool for precision diagnosis, stratification and follow-up of allergic patients
Identification of the molecular culprits of allergic reactions leveraged molecular allergology applications in clinical laboratory medicine. Molecular allergology shifted the focus from complex, heterogeneous allergenic extracts, e.g. pollen, food, or insect venom, towards genetically and immunologi...
Gespeichert in:
| Veröffentlicht in: | Clinical chemistry and laboratory medicine 2024-11, Vol.62 (12), p.2339-2355 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2355 |
|---|---|
| container_issue | 12 |
| container_start_page | 2339 |
| container_title | Clinical chemistry and laboratory medicine |
| container_volume | 62 |
| creator | Giusti, Delphine Guemari, Amir Perotin, Jeanne-Marie Fontaine, Jean-François Tonye Libyh, Marcelle Gatouillat, Gregory Tabary, Thierry Pham, Bach-Nga Vitte, Joana |
| description | Identification of the molecular culprits of allergic reactions leveraged molecular allergology applications in clinical laboratory medicine. Molecular allergology shifted the focus from complex, heterogeneous allergenic extracts, e.g. pollen, food, or insect venom, towards genetically and immunologically defined proteins available for
diagnosis. Molecular allergology is a precision medicine approach for the diagnosis, stratification, therapeutic management, follow-up and prognostic evaluation of patients within a large range of allergic diseases. Exclusively available for
diagnosis, molecular allergology is nonredundant with any of the current clinical tools for allergy investigation. As an example of a major application, discrimination of genuine sensitization from allergen cross-reactivity at the molecular level allows the proper targeting of the culprit allergen and thus dramatically improves patient management. This review aims at introducing clinical laboratory specialists to molecular allergology, from the biochemical and genetic bases, through immunological concepts, to daily use in the diagnosis and management of allergic diseases. |
| doi_str_mv | 10.1515/cclm-2024-0305 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_04601536v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3063458171</sourcerecordid><originalsourceid>FETCH-LOGICAL-c297t-f01cb09fb332c26fe0aeef3e769db83d4b548dae888e663d0a3e1441861ef6223</originalsourceid><addsrcrecordid>eNptksFrFDEUxgdRbK1ePUrAS4VOTfIymayHQinWFrZ40XPIZF7WlOxkTGYsC_7xZty1gnjKI_l930vel6p6zeg5a1jz3tqwrTnloqZAmyfVMRPQ1gKAPf1di1pKzo6qFznfU8qaRrTPqyNQqqgFO65-3sWAdg4mERMCpk0McbP7QAyxwQ_emkCC6WIyU0w7MsUYiIuJjAmtzz4OpPdmM8Ts8xnJU8G8K6JpOTFDX9gQ4kM9jyS6QwNvyVgAHKb8snrmTMj46rCeVF-vP365uqnXnz_dXl2ua8tX7VQ7ymxHV64D4JZLh9QgOsBWrvpOQS-6RqjeoFIKpYSeGkAmBFOSoZOcw0n1bu_7zQQ9Jr81aaej8frmcq2XPSpkmQ3IH6ywp3t2TPH7jHnSW58thmAGjHPWQCWIRrF2Qd_-g97HOQ3lJRoYa6QULYdCne8pm2LOCd3jDRjVS4Z6yVAvGeolwyJ4c7Cduy32j_if0ApwsQceTJgw9bhJ864Uf9v_37l8hDIMWMEvc1Ws6A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3115664723</pqid></control><display><type>article</type><title>Molecular allergology: a clinical laboratory tool for precision diagnosis, stratification and follow-up of allergic patients</title><source>De Gruyter journals</source><creator>Giusti, Delphine ; Guemari, Amir ; Perotin, Jeanne-Marie ; Fontaine, Jean-François ; Tonye Libyh, Marcelle ; Gatouillat, Gregory ; Tabary, Thierry ; Pham, Bach-Nga ; Vitte, Joana</creator><creatorcontrib>Giusti, Delphine ; Guemari, Amir ; Perotin, Jeanne-Marie ; Fontaine, Jean-François ; Tonye Libyh, Marcelle ; Gatouillat, Gregory ; Tabary, Thierry ; Pham, Bach-Nga ; Vitte, Joana</creatorcontrib><description>Identification of the molecular culprits of allergic reactions leveraged molecular allergology applications in clinical laboratory medicine. Molecular allergology shifted the focus from complex, heterogeneous allergenic extracts, e.g. pollen, food, or insect venom, towards genetically and immunologically defined proteins available for
diagnosis. Molecular allergology is a precision medicine approach for the diagnosis, stratification, therapeutic management, follow-up and prognostic evaluation of patients within a large range of allergic diseases. Exclusively available for
diagnosis, molecular allergology is nonredundant with any of the current clinical tools for allergy investigation. As an example of a major application, discrimination of genuine sensitization from allergen cross-reactivity at the molecular level allows the proper targeting of the culprit allergen and thus dramatically improves patient management. This review aims at introducing clinical laboratory specialists to molecular allergology, from the biochemical and genetic bases, through immunological concepts, to daily use in the diagnosis and management of allergic diseases.</description><identifier>ISSN: 1434-6621</identifier><identifier>ISSN: 1437-4331</identifier><identifier>EISSN: 1437-4331</identifier><identifier>DOI: 10.1515/cclm-2024-0305</identifier><identifier>PMID: 38815141</identifier><language>eng</language><publisher>Germany: De Gruyter</publisher><subject>Allergens ; Allergic diseases ; Allergic reactions ; Allergies ; allergy diagnosis ; Cross-reactivity ; Diagnosis ; Disease management ; Food allergies ; Food availability ; hypersensitivity ; immunoglobulin E ; Immunology ; Insects ; Life Sciences ; Medical laboratories ; molecular allergen ; Pollen ; Precision medicine ; Venom</subject><ispartof>Clinical chemistry and laboratory medicine, 2024-11, Vol.62 (12), p.2339-2355</ispartof><rights>2024 Walter de Gruyter GmbH, Berlin/Boston.</rights><rights>2024 Walter de Gruyter GmbH, Berlin/Boston</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c297t-f01cb09fb332c26fe0aeef3e769db83d4b548dae888e663d0a3e1441861ef6223</cites><orcidid>0000-0003-0343-9783 ; 0000-0003-4615-3742 ; 0000-0001-7184-3767 ; 0000-0002-3344-9408 ; 0000-0001-6857-4842 ; 0000-0003-1336-9483 ; 0009-0005-2745-1412 ; 0000-0001-6301-589X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.degruyter.com/document/doi/10.1515/cclm-2024-0305/pdf$$EPDF$$P50$$Gwalterdegruyter$$H</linktopdf><linktohtml>$$Uhttps://www.degruyter.com/document/doi/10.1515/cclm-2024-0305/html$$EHTML$$P50$$Gwalterdegruyter$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,66497,68281</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38815141$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.univ-reims.fr/hal-04601536$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Giusti, Delphine</creatorcontrib><creatorcontrib>Guemari, Amir</creatorcontrib><creatorcontrib>Perotin, Jeanne-Marie</creatorcontrib><creatorcontrib>Fontaine, Jean-François</creatorcontrib><creatorcontrib>Tonye Libyh, Marcelle</creatorcontrib><creatorcontrib>Gatouillat, Gregory</creatorcontrib><creatorcontrib>Tabary, Thierry</creatorcontrib><creatorcontrib>Pham, Bach-Nga</creatorcontrib><creatorcontrib>Vitte, Joana</creatorcontrib><title>Molecular allergology: a clinical laboratory tool for precision diagnosis, stratification and follow-up of allergic patients</title><title>Clinical chemistry and laboratory medicine</title><addtitle>Clin Chem Lab Med</addtitle><description>Identification of the molecular culprits of allergic reactions leveraged molecular allergology applications in clinical laboratory medicine. Molecular allergology shifted the focus from complex, heterogeneous allergenic extracts, e.g. pollen, food, or insect venom, towards genetically and immunologically defined proteins available for
diagnosis. Molecular allergology is a precision medicine approach for the diagnosis, stratification, therapeutic management, follow-up and prognostic evaluation of patients within a large range of allergic diseases. Exclusively available for
diagnosis, molecular allergology is nonredundant with any of the current clinical tools for allergy investigation. As an example of a major application, discrimination of genuine sensitization from allergen cross-reactivity at the molecular level allows the proper targeting of the culprit allergen and thus dramatically improves patient management. This review aims at introducing clinical laboratory specialists to molecular allergology, from the biochemical and genetic bases, through immunological concepts, to daily use in the diagnosis and management of allergic diseases.</description><subject>Allergens</subject><subject>Allergic diseases</subject><subject>Allergic reactions</subject><subject>Allergies</subject><subject>allergy diagnosis</subject><subject>Cross-reactivity</subject><subject>Diagnosis</subject><subject>Disease management</subject><subject>Food allergies</subject><subject>Food availability</subject><subject>hypersensitivity</subject><subject>immunoglobulin E</subject><subject>Immunology</subject><subject>Insects</subject><subject>Life Sciences</subject><subject>Medical laboratories</subject><subject>molecular allergen</subject><subject>Pollen</subject><subject>Precision medicine</subject><subject>Venom</subject><issn>1434-6621</issn><issn>1437-4331</issn><issn>1437-4331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNptksFrFDEUxgdRbK1ePUrAS4VOTfIymayHQinWFrZ40XPIZF7WlOxkTGYsC_7xZty1gnjKI_l930vel6p6zeg5a1jz3tqwrTnloqZAmyfVMRPQ1gKAPf1di1pKzo6qFznfU8qaRrTPqyNQqqgFO65-3sWAdg4mERMCpk0McbP7QAyxwQ_emkCC6WIyU0w7MsUYiIuJjAmtzz4OpPdmM8Ts8xnJU8G8K6JpOTFDX9gQ4kM9jyS6QwNvyVgAHKb8snrmTMj46rCeVF-vP365uqnXnz_dXl2ua8tX7VQ7ymxHV64D4JZLh9QgOsBWrvpOQS-6RqjeoFIKpYSeGkAmBFOSoZOcw0n1bu_7zQQ9Jr81aaej8frmcq2XPSpkmQ3IH6ywp3t2TPH7jHnSW58thmAGjHPWQCWIRrF2Qd_-g97HOQ3lJRoYa6QULYdCne8pm2LOCd3jDRjVS4Z6yVAvGeolwyJ4c7Cduy32j_if0ApwsQceTJgw9bhJ864Uf9v_37l8hDIMWMEvc1Ws6A</recordid><startdate>20241126</startdate><enddate>20241126</enddate><creator>Giusti, Delphine</creator><creator>Guemari, Amir</creator><creator>Perotin, Jeanne-Marie</creator><creator>Fontaine, Jean-François</creator><creator>Tonye Libyh, Marcelle</creator><creator>Gatouillat, Gregory</creator><creator>Tabary, Thierry</creator><creator>Pham, Bach-Nga</creator><creator>Vitte, Joana</creator><general>De Gruyter</general><general>Walter De Gruyter & Company</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-0343-9783</orcidid><orcidid>https://orcid.org/0000-0003-4615-3742</orcidid><orcidid>https://orcid.org/0000-0001-7184-3767</orcidid><orcidid>https://orcid.org/0000-0002-3344-9408</orcidid><orcidid>https://orcid.org/0000-0001-6857-4842</orcidid><orcidid>https://orcid.org/0000-0003-1336-9483</orcidid><orcidid>https://orcid.org/0009-0005-2745-1412</orcidid><orcidid>https://orcid.org/0000-0001-6301-589X</orcidid></search><sort><creationdate>20241126</creationdate><title>Molecular allergology: a clinical laboratory tool for precision diagnosis, stratification and follow-up of allergic patients</title><author>Giusti, Delphine ; Guemari, Amir ; Perotin, Jeanne-Marie ; Fontaine, Jean-François ; Tonye Libyh, Marcelle ; Gatouillat, Gregory ; Tabary, Thierry ; Pham, Bach-Nga ; Vitte, Joana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c297t-f01cb09fb332c26fe0aeef3e769db83d4b548dae888e663d0a3e1441861ef6223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Allergens</topic><topic>Allergic diseases</topic><topic>Allergic reactions</topic><topic>Allergies</topic><topic>allergy diagnosis</topic><topic>Cross-reactivity</topic><topic>Diagnosis</topic><topic>Disease management</topic><topic>Food allergies</topic><topic>Food availability</topic><topic>hypersensitivity</topic><topic>immunoglobulin E</topic><topic>Immunology</topic><topic>Insects</topic><topic>Life Sciences</topic><topic>Medical laboratories</topic><topic>molecular allergen</topic><topic>Pollen</topic><topic>Precision medicine</topic><topic>Venom</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giusti, Delphine</creatorcontrib><creatorcontrib>Guemari, Amir</creatorcontrib><creatorcontrib>Perotin, Jeanne-Marie</creatorcontrib><creatorcontrib>Fontaine, Jean-François</creatorcontrib><creatorcontrib>Tonye Libyh, Marcelle</creatorcontrib><creatorcontrib>Gatouillat, Gregory</creatorcontrib><creatorcontrib>Tabary, Thierry</creatorcontrib><creatorcontrib>Pham, Bach-Nga</creatorcontrib><creatorcontrib>Vitte, Joana</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Clinical chemistry and laboratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giusti, Delphine</au><au>Guemari, Amir</au><au>Perotin, Jeanne-Marie</au><au>Fontaine, Jean-François</au><au>Tonye Libyh, Marcelle</au><au>Gatouillat, Gregory</au><au>Tabary, Thierry</au><au>Pham, Bach-Nga</au><au>Vitte, Joana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular allergology: a clinical laboratory tool for precision diagnosis, stratification and follow-up of allergic patients</atitle><jtitle>Clinical chemistry and laboratory medicine</jtitle><addtitle>Clin Chem Lab Med</addtitle><date>2024-11-26</date><risdate>2024</risdate><volume>62</volume><issue>12</issue><spage>2339</spage><epage>2355</epage><pages>2339-2355</pages><issn>1434-6621</issn><issn>1437-4331</issn><eissn>1437-4331</eissn><abstract>Identification of the molecular culprits of allergic reactions leveraged molecular allergology applications in clinical laboratory medicine. Molecular allergology shifted the focus from complex, heterogeneous allergenic extracts, e.g. pollen, food, or insect venom, towards genetically and immunologically defined proteins available for
diagnosis. Molecular allergology is a precision medicine approach for the diagnosis, stratification, therapeutic management, follow-up and prognostic evaluation of patients within a large range of allergic diseases. Exclusively available for
diagnosis, molecular allergology is nonredundant with any of the current clinical tools for allergy investigation. As an example of a major application, discrimination of genuine sensitization from allergen cross-reactivity at the molecular level allows the proper targeting of the culprit allergen and thus dramatically improves patient management. This review aims at introducing clinical laboratory specialists to molecular allergology, from the biochemical and genetic bases, through immunological concepts, to daily use in the diagnosis and management of allergic diseases.</abstract><cop>Germany</cop><pub>De Gruyter</pub><pmid>38815141</pmid><doi>10.1515/cclm-2024-0305</doi><tpages>017</tpages><orcidid>https://orcid.org/0000-0003-0343-9783</orcidid><orcidid>https://orcid.org/0000-0003-4615-3742</orcidid><orcidid>https://orcid.org/0000-0001-7184-3767</orcidid><orcidid>https://orcid.org/0000-0002-3344-9408</orcidid><orcidid>https://orcid.org/0000-0001-6857-4842</orcidid><orcidid>https://orcid.org/0000-0003-1336-9483</orcidid><orcidid>https://orcid.org/0009-0005-2745-1412</orcidid><orcidid>https://orcid.org/0000-0001-6301-589X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1434-6621 |
| ispartof | Clinical chemistry and laboratory medicine, 2024-11, Vol.62 (12), p.2339-2355 |
| issn | 1434-6621 1437-4331 1437-4331 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_04601536v1 |
| source | De Gruyter journals |
| subjects | Allergens Allergic diseases Allergic reactions Allergies allergy diagnosis Cross-reactivity Diagnosis Disease management Food allergies Food availability hypersensitivity immunoglobulin E Immunology Insects Life Sciences Medical laboratories molecular allergen Pollen Precision medicine Venom |
| title | Molecular allergology: a clinical laboratory tool for precision diagnosis, stratification and follow-up of allergic patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T19%3A27%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Molecular%20allergology:%20a%20clinical%20laboratory%20tool%20for%20precision%20diagnosis,%20stratification%20and%20follow-up%20of%20allergic%20patients&rft.jtitle=Clinical%20chemistry%20and%20laboratory%20medicine&rft.au=Giusti,%20Delphine&rft.date=2024-11-26&rft.volume=62&rft.issue=12&rft.spage=2339&rft.epage=2355&rft.pages=2339-2355&rft.issn=1434-6621&rft.eissn=1437-4331&rft_id=info:doi/10.1515/cclm-2024-0305&rft_dat=%3Cproquest_hal_p%3E3063458171%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3115664723&rft_id=info:pmid/38815141&rfr_iscdi=true |