Sialic acids cleavage induced by elastin-derived peptides impairs the interaction between insulin and its receptor in adipocytes 3T3-L1

The insulin receptor (IR) plays an important role in insulin signal transduction, the defect of which is believed to be the root cause of type 2 diabetes. In 3T3-L1 adipocytes as in other cell types, the mature IR is a heterotetrameric cell surface glycoprotein composed of two α subunits and two β s...

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Veröffentlicht in:Journal of physiology and biochemistry 2024-05, Vol.80 (2), p.363-379
Hauptverfasser: Guillot, Alexandre, Toussaint, Kevin, Ebersold, Lucrece, ElBtaouri, Hassan, Thiebault, Emilie, Issad, Tarik, Peiretti, Franck, Maurice, Pascal, Sartelet, Hervé, Bennasroune, Amar, Martiny, Laurent, Dauchez, Manuel, Duca, Laurent, Durlach, Vincent, Romier, Béatrice, Baud, Stéphanie, Blaise, Sébastien
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Sprache:eng
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