Sialic acids cleavage induced by elastin-derived peptides impairs the interaction between insulin and its receptor in adipocytes 3T3-L1
The insulin receptor (IR) plays an important role in insulin signal transduction, the defect of which is believed to be the root cause of type 2 diabetes. In 3T3-L1 adipocytes as in other cell types, the mature IR is a heterotetrameric cell surface glycoprotein composed of two α subunits and two β s...
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Veröffentlicht in: | Journal of physiology and biochemistry 2024-05, Vol.80 (2), p.363-379 |
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Hauptverfasser: | , , , , , , , , , , , , , , , , |
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Sprache: | eng |
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