NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome

Inflammasomes are multiprotein complexes that drive inflammation and contribute to protective immunity against pathogens and immune pathology in autoinflammatory diseases. Inflammasomes assemble when an inflammasome scaffold protein senses an activating signal and forms a signaling platform with the...

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Veröffentlicht in:	Science signaling 2024-01, Vol.17 (820), p.eabg8145
Hauptverfasser:	Coombs, Jared R, Zamoshnikova, Alina, Holley, Caroline L, Maddugoda, Madhavi P, Teo, Daniel Eng Thiam, Chauvin, Camille, Poulin, Lionel F, Vitak, Nazarii, Ross, Connie M, Mellacheruvu, Manasa, Coll, Rebecca C, Heinz, Leonhard X, Burgener, Sabrina S, Emming, Stefan, Chamaillard, Mathias, Boucher, Dave, Schroder, Kate
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals Clinical trials Cytometry Disorders Hereditary Autoinflammatory Diseases Humans Immune response Inflammasomes Inflammatory diseases Innate immunity Intracellular Signaling Peptides and Proteins Leukocytes, Mononuclear Life Sciences Mice NLR Family, Pyrin Domain-Containing 3 Protein Syndrome
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