Regulation of cytokine expression in murine macrophages stimulated by excretory/secretory products from Trichinella spiralis in vitro

Trichinella spiralis is a zoonotic nematode and food borne parasite and infection with T. spiralis leads to suppression of the host immune response and other immunopathologies. The excretory/secretory (ES) products of T. spiralis play important roles in the process of immunomodulation. However, the...

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Veröffentlicht in:Molecular and cellular biochemistry 2012-01, Vol.360 (1-2), p.79-88
Hauptverfasser: Bai, Xue, Wu, Xiuping, Wang, Xuelin, Guan, Zhenhong, Gao, Fei, Yu, Jianli, Yu, Lu, Tang, Bin, Liu, Xiaolei, Song, Yanxia, Wang, Xinrui, Radu, Blaga, Boireau, Pascal, Wang, Feng, Liu, Mingyuan
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container_issue 1-2
container_start_page 79
container_title Molecular and cellular biochemistry
container_volume 360
creator Bai, Xue
Wu, Xiuping
Wang, Xuelin
Guan, Zhenhong
Gao, Fei
Yu, Jianli
Yu, Lu
Tang, Bin
Liu, Xiaolei
Song, Yanxia
Wang, Xinrui
Radu, Blaga
Boireau, Pascal
Wang, Feng
Liu, Mingyuan
description Trichinella spiralis is a zoonotic nematode and food borne parasite and infection with T. spiralis leads to suppression of the host immune response and other immunopathologies. The excretory/secretory (ES) products of T. spiralis play important roles in the process of immunomodulation. However, the mechanisms and related molecules are unknown. Macrophages, a target for immunomodulation by the helminth parasite, play a critical role in initiating and modulating the host immune response to parasite infection. In this study, we examined the effect of ES products from different stages of T. spiralis on modulating J774A.1 macrophage activities . ES products from different stages of T. spiralis reduced the capacity of macrophages to express pro-inflammatory cytokines (tumor necrosis factor α, interleukin-1β , interleukin-6 , and interleukin-12) in response to lipopolysaccharide (LPS) challenge. However, only ES products from 3-day-old adult worms and 5-day-old adult worms/new-born larvae significantly inhibited inducible nitric oxide synthase gene expression in LPS-induced macrophages. In addition, ES products alone boosted the expression of anti-inflammatory cytokines interleukin-10 and transforming growth factor-β and effector molecule arginase 1 in J774A.1 macrophages. Signal transduction studies showed that ES products significantly inhibited nuclear factor-κB translocation into the nucleus and the phosphorylation of both extracellular signal-regulated protein kinase 1/2 and p38 mitogen-activated protein kinase in LPS-stimulated J774A.1 macrophages. These results suggest that ES products regulate host immune response at the macrophage level through inhibition of pro-inflammatory cytokines production and induction of macrophage toward the alternative phenotype, which maybe important for worm survival and host health.
doi_str_mv 10.1007/s11010-011-1046-4
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The excretory/secretory (ES) products of T. spiralis play important roles in the process of immunomodulation. However, the mechanisms and related molecules are unknown. Macrophages, a target for immunomodulation by the helminth parasite, play a critical role in initiating and modulating the host immune response to parasite infection. In this study, we examined the effect of ES products from different stages of T. spiralis on modulating J774A.1 macrophage activities . ES products from different stages of T. spiralis reduced the capacity of macrophages to express pro-inflammatory cytokines (tumor necrosis factor α, interleukin-1β , interleukin-6 , and interleukin-12) in response to lipopolysaccharide (LPS) challenge. However, only ES products from 3-day-old adult worms and 5-day-old adult worms/new-born larvae significantly inhibited inducible nitric oxide synthase gene expression in LPS-induced macrophages. In addition, ES products alone boosted the expression of anti-inflammatory cytokines interleukin-10 and transforming growth factor-β and effector molecule arginase 1 in J774A.1 macrophages. Signal transduction studies showed that ES products significantly inhibited nuclear factor-κB translocation into the nucleus and the phosphorylation of both extracellular signal-regulated protein kinase 1/2 and p38 mitogen-activated protein kinase in LPS-stimulated J774A.1 macrophages. 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In addition, ES products alone boosted the expression of anti-inflammatory cytokines interleukin-10 and transforming growth factor-β and effector molecule arginase 1 in J774A.1 macrophages. Signal transduction studies showed that ES products significantly inhibited nuclear factor-κB translocation into the nucleus and the phosphorylation of both extracellular signal-regulated protein kinase 1/2 and p38 mitogen-activated protein kinase in LPS-stimulated J774A.1 macrophages. 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In addition, ES products alone boosted the expression of anti-inflammatory cytokines interleukin-10 and transforming growth factor-β and effector molecule arginase 1 in J774A.1 macrophages. Signal transduction studies showed that ES products significantly inhibited nuclear factor-κB translocation into the nucleus and the phosphorylation of both extracellular signal-regulated protein kinase 1/2 and p38 mitogen-activated protein kinase in LPS-stimulated J774A.1 macrophages. 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subjects Active Transport, Cell Nucleus - drug effects
Animals
Arginase
Biochemistry
Biomedical and Life Sciences
Bone morphogenetic proteins
Cardiology
Cell Line
Cell Nucleus - metabolism
Cell Survival - drug effects
Culture Media, Conditioned - pharmacology
Cytokines
Cytokines - genetics
Cytokines - metabolism
Gene expression
Gene Expression - drug effects
Gene Expression Regulation
Health aspects
Host-Parasite Interactions
Inflammation - chemically induced
Inflammation - metabolism
Larva - metabolism
Life Sciences
Lipopolysaccharides
Macrophages
Macrophages - drug effects
Macrophages - enzymology
Macrophages - metabolism
Medical Biochemistry
Mice
Mitogen-Activated Protein Kinases - metabolism
Mitogens
Nematoda
NF-kappa B - metabolism
Nitric oxide
Nitric Oxide Synthase Type II - metabolism
Oncology
Phosphorylation
Rats
Rats, Wistar
Trichinella spiralis - metabolism
title Regulation of cytokine expression in murine macrophages stimulated by excretory/secretory products from Trichinella spiralis in vitro
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