Hofbauer Cells and COVID-19 in Pregnancy
CONTEXT.—SARS-CoV-2 can undergo maternal-fetal transmission, heightening interest in the placental pathology findings from this infection. Transplacental SARS-CoV-2 transmission is typically accompanied by chronic histiocytic intervillositis together with necrosis and positivity of syncytiotrophobla...
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| Veröffentlicht in: | Archives of pathology & laboratory medicine (1976) 2021-11, Vol.145 (11), p.1328-1340 |
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| creator | Schwartz, David A. Baldewijns, Marcella Benachi, Alexandra Bugatti, Mattia Bulfamante, Gaetano Cheng, Ke Collins, Rebecca R.J. Debelenko, Larisa De Luca, Danièle Facchetti, Fabio Fitzgerald, Brendan Levitan, Daniel Linn, Rebecca L. Marcelis, Lukas Morotti, Denise Morotti, Raffaella Patanè, Luisa Prevot, Sophie Pulinx, Bianca Saad, Ali G. Schoenmakers, Sam Strybol, David Thomas, Kristen Tosi, Delfina Toto, Valentina van der Meeren, Lotte E. Verdijk, Robert M. Vivanti, Alexandre J. Zaigham, Mehreen |
| description | CONTEXT.—SARS-CoV-2 can undergo maternal-fetal transmission, heightening interest in the placental pathology findings from this infection. Transplacental SARS-CoV-2 transmission is typically accompanied by chronic histiocytic intervillositis together with necrosis and positivity of syncytiotrophoblast for SARS-CoV-2. Hofbauer cells are placental macrophages that have been involved in viral diseases, including HIV and Zika virus, but their involvement in SARS-CoV-2 is unknown. OBJECTIVE.—To determine whether SARS-CoV-2 can extend beyond the syncytiotrophoblast to enter Hofbauer cells, endothelium, and other villous stromal cells in infected placentas of liveborn and stillborn infants. DESIGN.—Case-based retrospective analysis by 29 perinatal and molecular pathology specialists of placental findings from a preselected cohort of 22 SARS-CoV-2-infected placentas delivered to pregnant women testing positive for SARS-CoV-2 from 7 countries. Molecular pathology methods were used to investigate viral involvement of Hofbauer cells, villous capillary endothelium, syncytiotrophoblast, and other fetal-derived cells. RESULTS.—Chronic histiocytic intervillositis and trophoblast necrosis were present in all 22 placentas (100%). SARS-CoV-2 was identified in Hofbauer cells from 4 of 22 placentas (18.2%). Villous capillary endothelial staining was positive in 2 of 22 cases (9.1%), both of which also had viral positivity in Hofbauer cells. Syncytiotrophoblast staining occurred in 21 of 22 placentas (95.5%). Hofbauer cell hyperplasia was present in 3 of 22 placentas (13.6%). In the 7 cases having documented transplacental infection of the fetus, 2 (28.6%) occurred in placentas with Hofbauer cell staining positive for SARS-CoV-2. CONCLUSIONS.—SARS-CoV-2 can extend beyond the trophoblast into the villous stroma, involving Hofbauer cells and capillary endothelial cells, in a small number of infected placentas. Most cases of SARS-CoV-2 transplacental fetal infection occur without Hofbauer cell involvement. |
| doi_str_mv | 10.5858/arpa.2021-0296-SA |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_04534942v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2555107630</sourcerecordid><originalsourceid>FETCH-LOGICAL-c200a-98d3a9d5747502ec29d5328d5a5a406835bac9d85afb39ee41ffaf2f5f8564c23</originalsourceid><addsrcrecordid>eNo9kE1Lw0AQhhdRsFZ_gLcc62Hrfk26ewzR2kKhQtXrMt3saiRN6q4V-u9NqHiamZeHF-Yh5JazKWjQ9xj3OBVMcMqEyemmOCMjDkpSwXM4JyPGmKTGaLgkVyl99qcRgo_IZNGFLR58zErfNCnDtsrK9dvygXKT1W32HP17i607XpOLgE3yN39zTF7njy_lgq7WT8uyWFEnGENqdCXRVDBTM2DCO9HvUugKEFCxXEvYojOVBgxbabxXPAQMIkDQkCsn5JjcnXo_sLH7WO8wHm2HtV0UKztkTIFURokf3rOTE7uP3dfBp2-7q5Pr_8DWd4dkBQBwNssl61F-Ql3sUoo-_HdzZgeDdjBoB4N2MGg3hfwFMoVhYQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2555107630</pqid></control><display><type>article</type><title>Hofbauer Cells and COVID-19 in Pregnancy</title><source>Allen Press Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Schwartz, David A. ; Baldewijns, Marcella ; Benachi, Alexandra ; Bugatti, Mattia ; Bulfamante, Gaetano ; Cheng, Ke ; Collins, Rebecca R.J. ; Debelenko, Larisa ; De Luca, Danièle ; Facchetti, Fabio ; Fitzgerald, Brendan ; Levitan, Daniel ; Linn, Rebecca L. ; Marcelis, Lukas ; Morotti, Denise ; Morotti, Raffaella ; Patanè, Luisa ; Prevot, Sophie ; Pulinx, Bianca ; Saad, Ali G. ; Schoenmakers, Sam ; Strybol, David ; Thomas, Kristen ; Tosi, Delfina ; Toto, Valentina ; van der Meeren, Lotte E. ; Verdijk, Robert M. ; Vivanti, Alexandre J. ; Zaigham, Mehreen</creator><creatorcontrib>Schwartz, David A. ; Baldewijns, Marcella ; Benachi, Alexandra ; Bugatti, Mattia ; Bulfamante, Gaetano ; Cheng, Ke ; Collins, Rebecca R.J. ; Debelenko, Larisa ; De Luca, Danièle ; Facchetti, Fabio ; Fitzgerald, Brendan ; Levitan, Daniel ; Linn, Rebecca L. ; Marcelis, Lukas ; Morotti, Denise ; Morotti, Raffaella ; Patanè, Luisa ; Prevot, Sophie ; Pulinx, Bianca ; Saad, Ali G. ; Schoenmakers, Sam ; Strybol, David ; Thomas, Kristen ; Tosi, Delfina ; Toto, Valentina ; van der Meeren, Lotte E. ; Verdijk, Robert M. ; Vivanti, Alexandre J. ; Zaigham, Mehreen</creatorcontrib><description>CONTEXT.—SARS-CoV-2 can undergo maternal-fetal transmission, heightening interest in the placental pathology findings from this infection. Transplacental SARS-CoV-2 transmission is typically accompanied by chronic histiocytic intervillositis together with necrosis and positivity of syncytiotrophoblast for SARS-CoV-2. Hofbauer cells are placental macrophages that have been involved in viral diseases, including HIV and Zika virus, but their involvement in SARS-CoV-2 is unknown. OBJECTIVE.—To determine whether SARS-CoV-2 can extend beyond the syncytiotrophoblast to enter Hofbauer cells, endothelium, and other villous stromal cells in infected placentas of liveborn and stillborn infants. DESIGN.—Case-based retrospective analysis by 29 perinatal and molecular pathology specialists of placental findings from a preselected cohort of 22 SARS-CoV-2-infected placentas delivered to pregnant women testing positive for SARS-CoV-2 from 7 countries. Molecular pathology methods were used to investigate viral involvement of Hofbauer cells, villous capillary endothelium, syncytiotrophoblast, and other fetal-derived cells. RESULTS.—Chronic histiocytic intervillositis and trophoblast necrosis were present in all 22 placentas (100%). SARS-CoV-2 was identified in Hofbauer cells from 4 of 22 placentas (18.2%). Villous capillary endothelial staining was positive in 2 of 22 cases (9.1%), both of which also had viral positivity in Hofbauer cells. Syncytiotrophoblast staining occurred in 21 of 22 placentas (95.5%). Hofbauer cell hyperplasia was present in 3 of 22 placentas (13.6%). In the 7 cases having documented transplacental infection of the fetus, 2 (28.6%) occurred in placentas with Hofbauer cell staining positive for SARS-CoV-2. CONCLUSIONS.—SARS-CoV-2 can extend beyond the trophoblast into the villous stroma, involving Hofbauer cells and capillary endothelial cells, in a small number of infected placentas. Most cases of SARS-CoV-2 transplacental fetal infection occur without Hofbauer cell involvement.</description><identifier>ISSN: 0003-9985</identifier><identifier>EISSN: 1543-2165</identifier><identifier>DOI: 10.5858/arpa.2021-0296-SA</identifier><language>eng</language><publisher>College of American Pathologists</publisher><subject>Life Sciences</subject><ispartof>Archives of pathology & laboratory medicine (1976), 2021-11, Vol.145 (11), p.1328-1340</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c200a-98d3a9d5747502ec29d5328d5a5a406835bac9d85afb39ee41ffaf2f5f8564c23</citedby><cites>FETCH-LOGICAL-c200a-98d3a9d5747502ec29d5328d5a5a406835bac9d85afb39ee41ffaf2f5f8564c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://hal.science/hal-04534942$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Schwartz, David A.</creatorcontrib><creatorcontrib>Baldewijns, Marcella</creatorcontrib><creatorcontrib>Benachi, Alexandra</creatorcontrib><creatorcontrib>Bugatti, Mattia</creatorcontrib><creatorcontrib>Bulfamante, Gaetano</creatorcontrib><creatorcontrib>Cheng, Ke</creatorcontrib><creatorcontrib>Collins, Rebecca R.J.</creatorcontrib><creatorcontrib>Debelenko, Larisa</creatorcontrib><creatorcontrib>De Luca, Danièle</creatorcontrib><creatorcontrib>Facchetti, Fabio</creatorcontrib><creatorcontrib>Fitzgerald, Brendan</creatorcontrib><creatorcontrib>Levitan, Daniel</creatorcontrib><creatorcontrib>Linn, Rebecca L.</creatorcontrib><creatorcontrib>Marcelis, Lukas</creatorcontrib><creatorcontrib>Morotti, Denise</creatorcontrib><creatorcontrib>Morotti, Raffaella</creatorcontrib><creatorcontrib>Patanè, Luisa</creatorcontrib><creatorcontrib>Prevot, Sophie</creatorcontrib><creatorcontrib>Pulinx, Bianca</creatorcontrib><creatorcontrib>Saad, Ali G.</creatorcontrib><creatorcontrib>Schoenmakers, Sam</creatorcontrib><creatorcontrib>Strybol, David</creatorcontrib><creatorcontrib>Thomas, Kristen</creatorcontrib><creatorcontrib>Tosi, Delfina</creatorcontrib><creatorcontrib>Toto, Valentina</creatorcontrib><creatorcontrib>van der Meeren, Lotte E.</creatorcontrib><creatorcontrib>Verdijk, Robert M.</creatorcontrib><creatorcontrib>Vivanti, Alexandre J.</creatorcontrib><creatorcontrib>Zaigham, Mehreen</creatorcontrib><title>Hofbauer Cells and COVID-19 in Pregnancy</title><title>Archives of pathology & laboratory medicine (1976)</title><description>CONTEXT.—SARS-CoV-2 can undergo maternal-fetal transmission, heightening interest in the placental pathology findings from this infection. Transplacental SARS-CoV-2 transmission is typically accompanied by chronic histiocytic intervillositis together with necrosis and positivity of syncytiotrophoblast for SARS-CoV-2. Hofbauer cells are placental macrophages that have been involved in viral diseases, including HIV and Zika virus, but their involvement in SARS-CoV-2 is unknown. OBJECTIVE.—To determine whether SARS-CoV-2 can extend beyond the syncytiotrophoblast to enter Hofbauer cells, endothelium, and other villous stromal cells in infected placentas of liveborn and stillborn infants. DESIGN.—Case-based retrospective analysis by 29 perinatal and molecular pathology specialists of placental findings from a preselected cohort of 22 SARS-CoV-2-infected placentas delivered to pregnant women testing positive for SARS-CoV-2 from 7 countries. Molecular pathology methods were used to investigate viral involvement of Hofbauer cells, villous capillary endothelium, syncytiotrophoblast, and other fetal-derived cells. RESULTS.—Chronic histiocytic intervillositis and trophoblast necrosis were present in all 22 placentas (100%). SARS-CoV-2 was identified in Hofbauer cells from 4 of 22 placentas (18.2%). Villous capillary endothelial staining was positive in 2 of 22 cases (9.1%), both of which also had viral positivity in Hofbauer cells. Syncytiotrophoblast staining occurred in 21 of 22 placentas (95.5%). Hofbauer cell hyperplasia was present in 3 of 22 placentas (13.6%). In the 7 cases having documented transplacental infection of the fetus, 2 (28.6%) occurred in placentas with Hofbauer cell staining positive for SARS-CoV-2. CONCLUSIONS.—SARS-CoV-2 can extend beyond the trophoblast into the villous stroma, involving Hofbauer cells and capillary endothelial cells, in a small number of infected placentas. Most cases of SARS-CoV-2 transplacental fetal infection occur without Hofbauer cell involvement.</description><subject>Life Sciences</subject><issn>0003-9985</issn><issn>1543-2165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNo9kE1Lw0AQhhdRsFZ_gLcc62Hrfk26ewzR2kKhQtXrMt3saiRN6q4V-u9NqHiamZeHF-Yh5JazKWjQ9xj3OBVMcMqEyemmOCMjDkpSwXM4JyPGmKTGaLgkVyl99qcRgo_IZNGFLR58zErfNCnDtsrK9dvygXKT1W32HP17i607XpOLgE3yN39zTF7njy_lgq7WT8uyWFEnGENqdCXRVDBTM2DCO9HvUugKEFCxXEvYojOVBgxbabxXPAQMIkDQkCsn5JjcnXo_sLH7WO8wHm2HtV0UKztkTIFURokf3rOTE7uP3dfBp2-7q5Pr_8DWd4dkBQBwNssl61F-Ql3sUoo-_HdzZgeDdjBoB4N2MGg3hfwFMoVhYQ</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Schwartz, David A.</creator><creator>Baldewijns, Marcella</creator><creator>Benachi, Alexandra</creator><creator>Bugatti, Mattia</creator><creator>Bulfamante, Gaetano</creator><creator>Cheng, Ke</creator><creator>Collins, Rebecca R.J.</creator><creator>Debelenko, Larisa</creator><creator>De Luca, Danièle</creator><creator>Facchetti, Fabio</creator><creator>Fitzgerald, Brendan</creator><creator>Levitan, Daniel</creator><creator>Linn, Rebecca L.</creator><creator>Marcelis, Lukas</creator><creator>Morotti, Denise</creator><creator>Morotti, Raffaella</creator><creator>Patanè, Luisa</creator><creator>Prevot, Sophie</creator><creator>Pulinx, Bianca</creator><creator>Saad, Ali G.</creator><creator>Schoenmakers, Sam</creator><creator>Strybol, David</creator><creator>Thomas, Kristen</creator><creator>Tosi, Delfina</creator><creator>Toto, Valentina</creator><creator>van der Meeren, Lotte E.</creator><creator>Verdijk, Robert M.</creator><creator>Vivanti, Alexandre J.</creator><creator>Zaigham, Mehreen</creator><general>College of American Pathologists</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>20211101</creationdate><title>Hofbauer Cells and COVID-19 in Pregnancy</title><author>Schwartz, David A. ; Baldewijns, Marcella ; Benachi, Alexandra ; Bugatti, Mattia ; Bulfamante, Gaetano ; Cheng, Ke ; Collins, Rebecca R.J. ; Debelenko, Larisa ; De Luca, Danièle ; Facchetti, Fabio ; Fitzgerald, Brendan ; Levitan, Daniel ; Linn, Rebecca L. ; Marcelis, Lukas ; Morotti, Denise ; Morotti, Raffaella ; Patanè, Luisa ; Prevot, Sophie ; Pulinx, Bianca ; Saad, Ali G. ; Schoenmakers, Sam ; Strybol, David ; Thomas, Kristen ; Tosi, Delfina ; Toto, Valentina ; van der Meeren, Lotte E. ; Verdijk, Robert M. ; Vivanti, Alexandre J. ; Zaigham, Mehreen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c200a-98d3a9d5747502ec29d5328d5a5a406835bac9d85afb39ee41ffaf2f5f8564c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Life Sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schwartz, David A.</creatorcontrib><creatorcontrib>Baldewijns, Marcella</creatorcontrib><creatorcontrib>Benachi, Alexandra</creatorcontrib><creatorcontrib>Bugatti, Mattia</creatorcontrib><creatorcontrib>Bulfamante, Gaetano</creatorcontrib><creatorcontrib>Cheng, Ke</creatorcontrib><creatorcontrib>Collins, Rebecca R.J.</creatorcontrib><creatorcontrib>Debelenko, Larisa</creatorcontrib><creatorcontrib>De Luca, Danièle</creatorcontrib><creatorcontrib>Facchetti, Fabio</creatorcontrib><creatorcontrib>Fitzgerald, Brendan</creatorcontrib><creatorcontrib>Levitan, Daniel</creatorcontrib><creatorcontrib>Linn, Rebecca L.</creatorcontrib><creatorcontrib>Marcelis, Lukas</creatorcontrib><creatorcontrib>Morotti, Denise</creatorcontrib><creatorcontrib>Morotti, Raffaella</creatorcontrib><creatorcontrib>Patanè, Luisa</creatorcontrib><creatorcontrib>Prevot, Sophie</creatorcontrib><creatorcontrib>Pulinx, Bianca</creatorcontrib><creatorcontrib>Saad, Ali G.</creatorcontrib><creatorcontrib>Schoenmakers, Sam</creatorcontrib><creatorcontrib>Strybol, David</creatorcontrib><creatorcontrib>Thomas, Kristen</creatorcontrib><creatorcontrib>Tosi, Delfina</creatorcontrib><creatorcontrib>Toto, Valentina</creatorcontrib><creatorcontrib>van der Meeren, Lotte E.</creatorcontrib><creatorcontrib>Verdijk, Robert M.</creatorcontrib><creatorcontrib>Vivanti, Alexandre J.</creatorcontrib><creatorcontrib>Zaigham, Mehreen</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Archives of pathology & laboratory medicine (1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schwartz, David A.</au><au>Baldewijns, Marcella</au><au>Benachi, Alexandra</au><au>Bugatti, Mattia</au><au>Bulfamante, Gaetano</au><au>Cheng, Ke</au><au>Collins, Rebecca R.J.</au><au>Debelenko, Larisa</au><au>De Luca, Danièle</au><au>Facchetti, Fabio</au><au>Fitzgerald, Brendan</au><au>Levitan, Daniel</au><au>Linn, Rebecca L.</au><au>Marcelis, Lukas</au><au>Morotti, Denise</au><au>Morotti, Raffaella</au><au>Patanè, Luisa</au><au>Prevot, Sophie</au><au>Pulinx, Bianca</au><au>Saad, Ali G.</au><au>Schoenmakers, Sam</au><au>Strybol, David</au><au>Thomas, Kristen</au><au>Tosi, Delfina</au><au>Toto, Valentina</au><au>van der Meeren, Lotte E.</au><au>Verdijk, Robert M.</au><au>Vivanti, Alexandre J.</au><au>Zaigham, Mehreen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hofbauer Cells and COVID-19 in Pregnancy</atitle><jtitle>Archives of pathology & laboratory medicine (1976)</jtitle><date>2021-11-01</date><risdate>2021</risdate><volume>145</volume><issue>11</issue><spage>1328</spage><epage>1340</epage><pages>1328-1340</pages><issn>0003-9985</issn><eissn>1543-2165</eissn><abstract>CONTEXT.—SARS-CoV-2 can undergo maternal-fetal transmission, heightening interest in the placental pathology findings from this infection. Transplacental SARS-CoV-2 transmission is typically accompanied by chronic histiocytic intervillositis together with necrosis and positivity of syncytiotrophoblast for SARS-CoV-2. Hofbauer cells are placental macrophages that have been involved in viral diseases, including HIV and Zika virus, but their involvement in SARS-CoV-2 is unknown. OBJECTIVE.—To determine whether SARS-CoV-2 can extend beyond the syncytiotrophoblast to enter Hofbauer cells, endothelium, and other villous stromal cells in infected placentas of liveborn and stillborn infants. DESIGN.—Case-based retrospective analysis by 29 perinatal and molecular pathology specialists of placental findings from a preselected cohort of 22 SARS-CoV-2-infected placentas delivered to pregnant women testing positive for SARS-CoV-2 from 7 countries. Molecular pathology methods were used to investigate viral involvement of Hofbauer cells, villous capillary endothelium, syncytiotrophoblast, and other fetal-derived cells. RESULTS.—Chronic histiocytic intervillositis and trophoblast necrosis were present in all 22 placentas (100%). SARS-CoV-2 was identified in Hofbauer cells from 4 of 22 placentas (18.2%). Villous capillary endothelial staining was positive in 2 of 22 cases (9.1%), both of which also had viral positivity in Hofbauer cells. Syncytiotrophoblast staining occurred in 21 of 22 placentas (95.5%). Hofbauer cell hyperplasia was present in 3 of 22 placentas (13.6%). In the 7 cases having documented transplacental infection of the fetus, 2 (28.6%) occurred in placentas with Hofbauer cell staining positive for SARS-CoV-2. CONCLUSIONS.—SARS-CoV-2 can extend beyond the trophoblast into the villous stroma, involving Hofbauer cells and capillary endothelial cells, in a small number of infected placentas. Most cases of SARS-CoV-2 transplacental fetal infection occur without Hofbauer cell involvement.</abstract><pub>College of American Pathologists</pub><doi>10.5858/arpa.2021-0296-SA</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Life Sciences |
| title | Hofbauer Cells and COVID-19 in Pregnancy |
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