Peptide‐Based Hydrogel for Nanosystems Encapsulation: the Next Generation of Localized Delivery Systems for the Treatment of Intestinal Inflammations
Conventional therapies for inflammatory bowel diseases are mainly based on systemic treatments which cause side effects and toxicity over long‐term administration. Nanoparticles appear as a valid alternative to allow a preferential accumulation in inflamed tissues following oral administration while...
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| Veröffentlicht in: | Advanced healthcare materials 2024-06, Vol.13 (16), p.e2303280-n/a |
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| creator | Andretto, Valentina Rosso, Annalisa Zilio, Serena Sidi‐Boumedine, Jacqueline Boschetti, Gilles Sankar, Sharanya Buffier, Marie Miele, Adriana Erica Denis, Morgane Choffour, Pierre‐Antoine Briançon, Stéphanie Nancey, Stéphane Kryza, David Lollo, Giovanna |
| description | Conventional therapies for inflammatory bowel diseases are mainly based on systemic treatments which cause side effects and toxicity over long‐term administration. Nanoparticles appear as a valid alternative to allow a preferential accumulation in inflamed tissues following oral administration while reducing systemic drug exposure. To increase their residence time in the inflamed intestine, the nanoparticles are here associated with a hydrogel matrix. A bioadhesive peptide‐based hydrogel is mixed with nanoemulsions, creating a hybrid lipid‐polymer nanocomposite. Mucopenetrating nanoemulsions of 100 nm are embedded in a scaffold constituted of the self‐assembling peptide hydrogel product PuraStat. The nanocomposite is fully characterized to study the impact of lipid particles in the hydrogel structure. Rheological measurements and circular dichroism analyses are performed to investigate the system's microstructure and physical properties. Biodistribution studies demonstrate that the nanocomposite acts as a depot in the stomach and facilitates the slow release of the nanoemulsions in the intestine. Efficacy studies upon oral administration of the drug‐loaded system show the improvement of the disease score in a mouse model of intestinal inflammation.
Local manipulation of immunological pathways causing intestinal inflammation represents a promising strategy for inflammatory bowel diseases treatment. Here, oral hybrid lipid‐polymer nanocomposite made of bioadhesive peptide‐based hydrogel mixed with tofacitinib‐loaded nanoemulsions for local intestinal immunomodulation is designed. The feasibility of the nanocomposite platform and the efficacy upon oral administration in a mouse model of intestinal inflammation are demonstrated. |
| doi_str_mv | 10.1002/adhm.202303280 |
| format | Article |
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Local manipulation of immunological pathways causing intestinal inflammation represents a promising strategy for inflammatory bowel diseases treatment. Here, oral hybrid lipid‐polymer nanocomposite made of bioadhesive peptide‐based hydrogel mixed with tofacitinib‐loaded nanoemulsions for local intestinal immunomodulation is designed. The feasibility of the nanocomposite platform and the efficacy upon oral administration in a mouse model of intestinal inflammation are demonstrated.</description><identifier>ISSN: 2192-2640</identifier><identifier>ISSN: 2192-2659</identifier><identifier>EISSN: 2192-2659</identifier><identifier>DOI: 10.1002/adhm.202303280</identifier><identifier>PMID: 38445812</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Bioaccumulation ; Circular dichroism ; Dichroism ; Galenic pharmacology ; hybrid systems ; Hydrogels ; Inflammatory bowel diseases ; inflammatory bowel diseases (IBDs) ; Intestine ; Life Sciences ; Lipids ; Nanocomposites ; Nanoemulsions ; Nanoparticles ; Oral administration ; oral delivery ; Peptides ; Pharmaceutical sciences ; Pharmacology ; Physical properties ; Rheological properties ; Self-assembly ; Side effects ; Toxicity</subject><ispartof>Advanced healthcare materials, 2024-06, Vol.13 (16), p.e2303280-n/a</ispartof><rights>2024 Wiley‐VCH GmbH</rights><rights>This article is protected by copyright. All rights reserved.</rights><rights>2024 Wiley‐VCH GmbH.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4070-d8e4b156460dbb8cb98381dad24b42c0ddf6b2d6711f99baf6fdc8d0d70762103</citedby><cites>FETCH-LOGICAL-c4070-d8e4b156460dbb8cb98381dad24b42c0ddf6b2d6711f99baf6fdc8d0d70762103</cites><orcidid>0000-0001-7030-3056 ; 0000-0003-2088-1442</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadhm.202303280$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadhm.202303280$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,777,781,882,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38445812$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04526888$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Andretto, Valentina</creatorcontrib><creatorcontrib>Rosso, Annalisa</creatorcontrib><creatorcontrib>Zilio, Serena</creatorcontrib><creatorcontrib>Sidi‐Boumedine, Jacqueline</creatorcontrib><creatorcontrib>Boschetti, Gilles</creatorcontrib><creatorcontrib>Sankar, Sharanya</creatorcontrib><creatorcontrib>Buffier, Marie</creatorcontrib><creatorcontrib>Miele, Adriana Erica</creatorcontrib><creatorcontrib>Denis, Morgane</creatorcontrib><creatorcontrib>Choffour, Pierre‐Antoine</creatorcontrib><creatorcontrib>Briançon, Stéphanie</creatorcontrib><creatorcontrib>Nancey, Stéphane</creatorcontrib><creatorcontrib>Kryza, David</creatorcontrib><creatorcontrib>Lollo, Giovanna</creatorcontrib><title>Peptide‐Based Hydrogel for Nanosystems Encapsulation: the Next Generation of Localized Delivery Systems for the Treatment of Intestinal Inflammations</title><title>Advanced healthcare materials</title><addtitle>Adv Healthc Mater</addtitle><description>Conventional therapies for inflammatory bowel diseases are mainly based on systemic treatments which cause side effects and toxicity over long‐term administration. Nanoparticles appear as a valid alternative to allow a preferential accumulation in inflamed tissues following oral administration while reducing systemic drug exposure. To increase their residence time in the inflamed intestine, the nanoparticles are here associated with a hydrogel matrix. A bioadhesive peptide‐based hydrogel is mixed with nanoemulsions, creating a hybrid lipid‐polymer nanocomposite. Mucopenetrating nanoemulsions of 100 nm are embedded in a scaffold constituted of the self‐assembling peptide hydrogel product PuraStat. The nanocomposite is fully characterized to study the impact of lipid particles in the hydrogel structure. Rheological measurements and circular dichroism analyses are performed to investigate the system's microstructure and physical properties. Biodistribution studies demonstrate that the nanocomposite acts as a depot in the stomach and facilitates the slow release of the nanoemulsions in the intestine. Efficacy studies upon oral administration of the drug‐loaded system show the improvement of the disease score in a mouse model of intestinal inflammation.
Local manipulation of immunological pathways causing intestinal inflammation represents a promising strategy for inflammatory bowel diseases treatment. Here, oral hybrid lipid‐polymer nanocomposite made of bioadhesive peptide‐based hydrogel mixed with tofacitinib‐loaded nanoemulsions for local intestinal immunomodulation is designed. The feasibility of the nanocomposite platform and the efficacy upon oral administration in a mouse model of intestinal inflammation are demonstrated.</description><subject>Bioaccumulation</subject><subject>Circular dichroism</subject><subject>Dichroism</subject><subject>Galenic pharmacology</subject><subject>hybrid systems</subject><subject>Hydrogels</subject><subject>Inflammatory bowel diseases</subject><subject>inflammatory bowel diseases (IBDs)</subject><subject>Intestine</subject><subject>Life Sciences</subject><subject>Lipids</subject><subject>Nanocomposites</subject><subject>Nanoemulsions</subject><subject>Nanoparticles</subject><subject>Oral administration</subject><subject>oral delivery</subject><subject>Peptides</subject><subject>Pharmaceutical sciences</subject><subject>Pharmacology</subject><subject>Physical properties</subject><subject>Rheological properties</subject><subject>Self-assembly</subject><subject>Side effects</subject><subject>Toxicity</subject><issn>2192-2640</issn><issn>2192-2659</issn><issn>2192-2659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkc9u1DAQhyMEolXplSOyxAUOu4wdx3G4Lf23lZaCRDlbTjxhUznx1k4K6YlH4Mb78SQ43WWRuOCLR6NvPs3olyTPKcwpAHujzbqdM2AppEzCo-SQ0YLNmMiKx_uaw0FyHMINxCcyKiR9mhykkvNMUnaY_PyIm74x-Ov7j3c6oCHL0Xj3BS2pnSdXunNhDD22gZx1ld6Eweq-cd1b0q-RXOG3nlxgh_6hSVxNVq7StrmPolO0zR36kXzaCSbhNHXtUfctdv3EX3Y9hr7ptI1lbXXbPqjCs-RJrW3A491_lHw-P7s-Wc5WHy4uTxarWcUhh5mRyEuaCS7AlKWsykKmkhptGC85q8CYWpTMiJzSuihKXYvaVNKAySEXjEJ6lLzeetfaqo1vWu1H5XSjlouVmnrAMyaklHc0sq-27Ma72yGurdomVGit7tANQbEilUwWjGcRffkPeuMGH68MKoWcioJCnkZqvqUq70LwWO83oKCmhNWUsNonHAde7LRD2aLZ43_yjECxBb42Fsf_6NTidPn-r_w3kcu0jw</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Andretto, Valentina</creator><creator>Rosso, Annalisa</creator><creator>Zilio, Serena</creator><creator>Sidi‐Boumedine, Jacqueline</creator><creator>Boschetti, Gilles</creator><creator>Sankar, Sharanya</creator><creator>Buffier, Marie</creator><creator>Miele, Adriana Erica</creator><creator>Denis, Morgane</creator><creator>Choffour, Pierre‐Antoine</creator><creator>Briançon, Stéphanie</creator><creator>Nancey, Stéphane</creator><creator>Kryza, David</creator><creator>Lollo, Giovanna</creator><general>Wiley Subscription Services, Inc</general><general>Wiley</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T5</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7TO</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-7030-3056</orcidid><orcidid>https://orcid.org/0000-0003-2088-1442</orcidid></search><sort><creationdate>20240601</creationdate><title>Peptide‐Based Hydrogel for Nanosystems Encapsulation: the Next Generation of Localized Delivery Systems for the Treatment of Intestinal Inflammations</title><author>Andretto, Valentina ; 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Nanoparticles appear as a valid alternative to allow a preferential accumulation in inflamed tissues following oral administration while reducing systemic drug exposure. To increase their residence time in the inflamed intestine, the nanoparticles are here associated with a hydrogel matrix. A bioadhesive peptide‐based hydrogel is mixed with nanoemulsions, creating a hybrid lipid‐polymer nanocomposite. Mucopenetrating nanoemulsions of 100 nm are embedded in a scaffold constituted of the self‐assembling peptide hydrogel product PuraStat. The nanocomposite is fully characterized to study the impact of lipid particles in the hydrogel structure. Rheological measurements and circular dichroism analyses are performed to investigate the system's microstructure and physical properties. Biodistribution studies demonstrate that the nanocomposite acts as a depot in the stomach and facilitates the slow release of the nanoemulsions in the intestine. Efficacy studies upon oral administration of the drug‐loaded system show the improvement of the disease score in a mouse model of intestinal inflammation.
Local manipulation of immunological pathways causing intestinal inflammation represents a promising strategy for inflammatory bowel diseases treatment. Here, oral hybrid lipid‐polymer nanocomposite made of bioadhesive peptide‐based hydrogel mixed with tofacitinib‐loaded nanoemulsions for local intestinal immunomodulation is designed. The feasibility of the nanocomposite platform and the efficacy upon oral administration in a mouse model of intestinal inflammation are demonstrated.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38445812</pmid><doi>10.1002/adhm.202303280</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0001-7030-3056</orcidid><orcidid>https://orcid.org/0000-0003-2088-1442</orcidid></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals |
| subjects | Bioaccumulation Circular dichroism Dichroism Galenic pharmacology hybrid systems Hydrogels Inflammatory bowel diseases inflammatory bowel diseases (IBDs) Intestine Life Sciences Lipids Nanocomposites Nanoemulsions Nanoparticles Oral administration oral delivery Peptides Pharmaceutical sciences Pharmacology Physical properties Rheological properties Self-assembly Side effects Toxicity |
| title | Peptide‐Based Hydrogel for Nanosystems Encapsulation: the Next Generation of Localized Delivery Systems for the Treatment of Intestinal Inflammations |
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