Paradoxical potentiation of the exercise pressor reflex by endomorphin 2 in the presence of naloxone

When contracting muscles are freely perfused, the acid-sensing ion channel 3 (ASIC3) on group IV afferents plays a minor role in evoking the exercise pressor reflex. We recently showed in isolated dorsal root ganglion neurons innervating the gastrocnemius muscles that two mu opioid receptor agonists...

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Veröffentlicht in:	Journal of applied physiology (1985) 2024-05, Vol.136 (5), p.1097-1104
Hauptverfasser:	Anselmi, Laura, Ducrocq, Guillaume P, Kim, Joyce S, Herold, Paul B, Ruiz-Velasco, Victor, Kaufman, Marc P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Sensing Ion Channels - metabolism Analgesics, Opioid - pharmacology Animals Blood pressure Blood Pressure - drug effects Blood Pressure - physiology Dorsal root ganglia Endomorphins Human health and pathology Ion channels Life Sciences Male Muscle contraction Muscle Contraction - drug effects Muscle Contraction - physiology Muscle, Skeletal - drug effects Muscle, Skeletal - physiology Muscles Naloxone Naloxone - pharmacology Narcotic Antagonists - pharmacology Narcotics Oligopeptides - pharmacology Opioid receptors (type mu) Oxycodone Oxycodone - administration & dosage Oxycodone - pharmacology Physical Conditioning, Animal - physiology Potentiation Rats Rats, Sprague-Dawley Receptors Receptors, Opioid, mu - metabolism Reflex - drug effects Reflex - physiology Tissues and Organs Triceps surae muscle
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