Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

Non-alcoholic steatohepatitis (NASH) is a common type of chronic liver disease that can lead to cirrhosis. Obeticholic acid, a farnesoid X receptor agonist, has been shown to improve the histological features of NASH. Here we report results from a planned interim analysis of an ongoing, phase 3 stud...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Lancet (British edition) 2019-12, Vol.394 (10215), p.2184-2196
Hauptverfasser:	Goodman, Zachary, Sheikh, Muhammad Y, Mazzella, Giuseppe, Gluud, Lise Lotte, Shapiro, David, Campagna, Jason, Shringarpure, Reshma, Abdelmalek, Manal, Aigner, Elmar, Alazawi, William, Allison, Michael, Andreone, Pietro, Arenas Ruiz, Juan Ignacio, Arkkila, Perttu, Berenguer, Marina, Bradley, David, Braun, Marius, Bruno, Savino, Calderon, Amy, Carey, Elizabeth, Cave, Matthew, Cruz Pereira, Oscar, de Ledinghen, Victor, Dufour, Jean-François, Falcone, Robert, Ferreira, Jose, Finnegan, Kevin, Francque, Sven, Freilich, Bradley, Frias, Juan, Fuchs, Michael, Fuentes, Javier, Geerts, Anja, Geier, Andreas, George, Jacob, Gholam, Pierre, Goff, John, Gordon, Frederic, Greer, Shaun, Gunaratnam, Naresh, Harrison, Stephen, Hartleb, Marek, Heurich, Eva, Holland Fischer, Peter, Jeffers, Lennox, Kaita, Kelly, Kechagias, Stergios, Knapple, Whitfield, Korenblat, Kevin, Krag, Aleksander, Krause, Richard, Krok, Karen, Kuwada, Scott, Lee, Alice, Long, Michelle, Lurie, Yoav, Macedo, Guilherme, Mantry, Parvez, Marinho, Carla, Marschall, Hanns-Ulrich, McCullen, Mark, Molina, Esther, Montano-Loza, Aldo, Monteverde, Carlos, Muellhaupt, Beat, Naik, Jahnavi, Nguyen-Khac, Eric, Olveira, Antonio, Orr, David, Paredes, Angelo, Patel, Joykumar, Patel, Keyur, Piekarska, Anna, Pyrsopoulos, Nikolaos, Rafiq, Nila, Muller, Kate, Riera, Andres, Rinella, Mary, Rivera Acosta, Jose, Rushbrook, Simon, Ryan, Michael, Salminen, Kimmo, Schneider, Jeffrey, Sheikh, Aasim, Sheridan, David, Sherman, Kenneth, Siddique, Asma, Solis, Joel, Strasser, Simone, Svorcan, Petar, Talal, Andrew, Thuluvath, Paul, Tsochatzis, Emanuel, Veitsman, Ella, Vespasiani Gentilucci, Umberto, Victor, David, von der Ohe, Manfred, Waters, Michael, Wieland, Amanda, Yataco, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Acids Administration, Oral Analysis Biochemical markers Biomarkers - analysis Biopsy Chenodeoxycholic Acid - administration & dosage Chenodeoxycholic Acid - analogs & derivatives Chenodeoxycholic Acid - therapeutic use Cholesterol Cirrhosis Clinical outcomes Clinical significance Clinical trials Diabetes Disease control Double-Blind Method Double-blind studies Fatty liver FDA approval Female Fibrosis Humans Incidence Inflammation Interactive systems Life Sciences Liver Liver cirrhosis Liver diseases Liver Function Tests Low density lipoprotein Male Medical prognosis Metabolism Middle Aged Non-alcoholic Fatty Liver Disease - drug therapy Pain Patients Pruritus Randomization Safety
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!