Neuroinvasion of SARS-CoV-2 in human and mouse brain

Although COVID-19 is considered to be primarily a respiratory disease, SARS-CoV-2 affects multiple organ systems including the central nervous system (CNS). Yet, there is no consensus on the consequences of CNS infections. Here, we used three independent approaches to probe the capacity of SARS-CoV-...

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Veröffentlicht in:	The Journal of experimental medicine 2021-03, Vol.218 (3)
Hauptverfasser:	Song, Eric, Zhang, Ce, Israelow, Benjamin, Lu-Culligan, Alice, Prado, Alba Vieites, Skriabine, Sophie, Lu, Peiwen, Weizman, Orr-El, Liu, Feimei, Dai, Yile, Szigeti-Buck, Klara, Yasumoto, Yuki, Wang, Guilin, Castaldi, Christopher, Heltke, Jaime, Ng, Evelyn, Wheeler, John, Alfajaro, Mia Madel, Levavasseur, Etienne, Fontes, Benjamin, Ravindra, Neal G, Van Dijk, David, Mane, Shrikant, Gunel, Murat, Ring, Aaron, Kazmi, Syed A Jaffar, Zhang, Kai, Wilen, Craig B, Horvath, Tamas L, Plu, Isabelle, Haik, Stephane, Thomas, Jean-Leon, Louvi, Angeliki, Farhadian, Shelli F, Huttner, Anita, Seilhean, Danielle, Renier, Nicolas, Bilguvar, Kaya, Iwasaki, Akiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin-Converting Enzyme 2 - antagonists & inhibitors Angiotensin-Converting Enzyme 2 - metabolism Animals Antibodies, Blocking - chemistry Cerebral Cortex - metabolism Cerebral Cortex - pathology Cerebral Cortex - virology COVID-19 - metabolism COVID-19 - pathology Disease Models, Animal Female Human health and pathology Humans Infectious Disease and Host Defense Life Sciences Male Mice Middle Aged Neurons - metabolism Neurons - pathology Neurons - virology Organoids - metabolism Organoids - pathology Organoids - virology SARS-CoV-2 - metabolism
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