Preventing Radiation-Induced Injury by Topical Application of an Amifostine Metabolite-Loaded Thermogel

Despite the development of high-precision radiation therapy, ionizing radiation inevitably damages healthy tissues. Radiodermatitis and radioinduced oral mucositis are frequent and significant side effects among patients with breast and head and neck cancer, respectively. These radiation-related inj...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2019-08, Vol.104 (5), p.1141-1152
Hauptverfasser:	Clémenson, Céline, Liu, Winchygn, Bricout, Denis, Soyez-Herkert, Loren, Chargari, Cyrus, Mondini, Michele, Haddad, Raphaël, Wang-Zhang, Xiuping, Benel, Laurent, Bloy, Christian, Deutsch, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Amifostine - administration & dosage Amifostine - adverse effects Animals Blood Pressure - drug effects Breast Neoplasms - radiotherapy Disease Models, Animal DNA Damage Dogs Drug Carriers Female Gels - administration & dosage Head and Neck Neoplasms - radiotherapy Hypotension, Orthostatic - chemically induced Life Sciences Mice Mice, Inbred C57BL Radiation Injuries, Experimental - drug therapy Radiation Injuries, Experimental - prevention & control Radiation-Protective Agents - administration & dosage Radiation-Protective Agents - adverse effects Radiodermatitis - drug therapy Radiodermatitis - prevention & control Random Allocation Skin Neoplasms - radiotherapy Stomatitis - drug therapy Stomatitis - etiology Stomatitis - prevention & control
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