Prophylactic cranial irradiation (PCI), hippocampal avoidance (HA) whole brain radiotherapy (WBRT) and stereotactic radiosurgery (SRS) in small cell lung cancer (SCLC): Where do we stand?

•SCLC is associated with a high risk of brain metastases.•The role of PCI remains controversial in certain patient subgroups.•Key PCI trials and current guidelines in both LS and ES SCLC summarised.•Role of hippocampal avoidance radiotherapy, neuroprotective drugs and SRS discussed.•Highlights areas...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2021-12, Vol.162, p.96-105
Hauptverfasser:	Crockett, Cathryn, Belderbos, José, Levy, Antonin, McDonald, Fiona, Le Péchoux, Cecile, Faivre-Finn, Corinne
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain metastases Brain Neoplasms - radiotherapy Brain Neoplasms - surgery Cancer Cranial Irradiation - adverse effects Hippocampal avoidance Hippocampus Humans Life Sciences Life Sciences & Biomedicine Lung Neoplasms - radiotherapy Neurotoxicity Oncology PCI Prospective Studies Quality of Life Radiosurgery - adverse effects Respiratory System Science & Technology SCLC Small Cell Lung Carcinoma - radiotherapy SRS
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