Reduction of paw edema and liver oxidative stress in carrageenan-induced acute inflammation by Lobaria pulmonaria and Parmelia caperata , lichen species, in mice
Paw edema volume reduction is a useful marker in determining the anti-inflammatory effect of drugs and plant extracts in carrageenan-induced acute inflammation. In this study, the anti-inflammatory effect of (LP) and (PC), two lichen species, was examined in carrageenan-induced mouse paw edema test....
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| Veröffentlicht in: | International journal for vitamin and nutrition research 2021-01, Vol.91 (1-2), p.143-151 |
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| container_title | International journal for vitamin and nutrition research |
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| creator | Salem, Samira Leghouchi, Essaid Soulimani, Rachid Bouayed, Jaouad |
| description | Paw edema volume reduction is a useful marker in determining the anti-inflammatory effect of drugs and plant extracts in carrageenan-induced acute inflammation. In this study, the anti-inflammatory effect of
(LP) and
(PC), two lichen species, was examined in carrageenan-induced mouse paw edema test. Compared to the controls in carrageenan-induced inflammation (n = 5/group), our results showed that pretreatment by single oral doses with PC extract (50-500 mg/kg) gives better results than LP extract (50-500 mg/kg) in terms of anti-edematous activity, as after 4 h of carrageenan subplantar injection, paw edema formation was inhibited at 82-99% by PC while at 35-49% by LP. The higher anti-inflammatory effect of PC, at all doses, was also observed on the time-course of carrageenan-induced paw edema, displaying profile closely similar to that obtained with diclofenac (25 mg/kg), an anti-inflammatory drug reference (all
|
| doi_str_mv | 10.1024/0300-9831/a000620 |
| format | Article |
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(LP) and
(PC), two lichen species, was examined in carrageenan-induced mouse paw edema test. Compared to the controls in carrageenan-induced inflammation (n = 5/group), our results showed that pretreatment by single oral doses with PC extract (50-500 mg/kg) gives better results than LP extract (50-500 mg/kg) in terms of anti-edematous activity, as after 4 h of carrageenan subplantar injection, paw edema formation was inhibited at 82-99% by PC while at 35-49% by LP. The higher anti-inflammatory effect of PC, at all doses, was also observed on the time-course of carrageenan-induced paw edema, displaying profile closely similar to that obtained with diclofenac (25 mg/kg), an anti-inflammatory drug reference (all
< 0.001). Both LP and PC, at all doses, significantly ameliorated liver catalase (CAT) activity (all
< 0.05). However, superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity and glutathione (GSH) levels were found increased in liver of PC- compared to LP-carrageenan-injected mice. Our findings demonstrated on one hand higher preventive effects of PC compared to LP in a mouse carrageenan-induced inflammatory model and suggested, on the other hand, that anti-inflammatory effects elicited by the two lichens were closely associated with the amelioration in the endogenous antioxidant status of liver.</description><identifier>ISSN: 0300-9831</identifier><identifier>EISSN: 1664-2821</identifier><identifier>DOI: 10.1024/0300-9831/a000620</identifier><identifier>PMID: 31847731</identifier><language>eng</language><publisher>Switzerland: Hogrefe</publisher><subject>Animals ; Ascomycota ; Carrageenan - metabolism ; Carrageenan - toxicity ; Edema - chemically induced ; Edema - drug therapy ; Edema - metabolism ; Inflammation - chemically induced ; Inflammation - drug therapy ; Inflammation - metabolism ; Lichens ; Life Sciences ; Liver - metabolism ; Mice ; Oxidative Stress ; Plant Extracts - pharmacology</subject><ispartof>International journal for vitamin and nutrition research, 2021-01, Vol.91 (1-2), p.143-151</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-de50b61a3f6dcf92da2a4c8dae07bc1e6569767b48e013531c7c1bf9cb59118a3</citedby><cites>FETCH-LOGICAL-c335t-de50b61a3f6dcf92da2a4c8dae07bc1e6569767b48e013531c7c1bf9cb59118a3</cites><orcidid>0000-0002-8410-2105</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31847731$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04502517$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Salem, Samira</creatorcontrib><creatorcontrib>Leghouchi, Essaid</creatorcontrib><creatorcontrib>Soulimani, Rachid</creatorcontrib><creatorcontrib>Bouayed, Jaouad</creatorcontrib><title>Reduction of paw edema and liver oxidative stress in carrageenan-induced acute inflammation by Lobaria pulmonaria and Parmelia caperata , lichen species, in mice</title><title>International journal for vitamin and nutrition research</title><addtitle>Int J Vitam Nutr Res</addtitle><description>Paw edema volume reduction is a useful marker in determining the anti-inflammatory effect of drugs and plant extracts in carrageenan-induced acute inflammation. In this study, the anti-inflammatory effect of
(LP) and
(PC), two lichen species, was examined in carrageenan-induced mouse paw edema test. Compared to the controls in carrageenan-induced inflammation (n = 5/group), our results showed that pretreatment by single oral doses with PC extract (50-500 mg/kg) gives better results than LP extract (50-500 mg/kg) in terms of anti-edematous activity, as after 4 h of carrageenan subplantar injection, paw edema formation was inhibited at 82-99% by PC while at 35-49% by LP. The higher anti-inflammatory effect of PC, at all doses, was also observed on the time-course of carrageenan-induced paw edema, displaying profile closely similar to that obtained with diclofenac (25 mg/kg), an anti-inflammatory drug reference (all
< 0.001). Both LP and PC, at all doses, significantly ameliorated liver catalase (CAT) activity (all
< 0.05). However, superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity and glutathione (GSH) levels were found increased in liver of PC- compared to LP-carrageenan-injected mice. Our findings demonstrated on one hand higher preventive effects of PC compared to LP in a mouse carrageenan-induced inflammatory model and suggested, on the other hand, that anti-inflammatory effects elicited by the two lichens were closely associated with the amelioration in the endogenous antioxidant status of liver.</description><subject>Animals</subject><subject>Ascomycota</subject><subject>Carrageenan - metabolism</subject><subject>Carrageenan - toxicity</subject><subject>Edema - chemically induced</subject><subject>Edema - drug therapy</subject><subject>Edema - metabolism</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - metabolism</subject><subject>Lichens</subject><subject>Life Sciences</subject><subject>Liver - metabolism</subject><subject>Mice</subject><subject>Oxidative Stress</subject><subject>Plant Extracts - pharmacology</subject><issn>0300-9831</issn><issn>1664-2821</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UctKxEAQHETRdfUDvMhcBeN2Z_I8iviCBUX0HDozHR3Ji5msup_jn5q4uqd-VFcVdAlxgnCBEEYLUABBnilcEAAkIeyIGSZJFIRZiLtitsUPxKH37wAqxSzaFwdqLGmqcCa-n9is9GC7VnaV7OlTsuGGJLVG1vaDney-rKFhbKUfHHsvbSs1OUevzC21gW1HATaS9GrgEaxqahr6VSzXctmV5CzJflU3XfvbTtKP5Bqux0FTz44GkuejnX7jVvqetWV_Pvk0VvOR2Kuo9nz8V-fi5eb6-eouWD7c3l9dLgOtVDwEhmMoEyRVJUZXeWgopEhnhhjSUiMncZKnSVpGGQOqWKFONZZVrss4R8xIzcXZRveN6qJ3tiG3Ljqyxd3lsph2EMUQxph-4HiLm1vtOu8dV1sCQjFFU0yvL6bXF3_RjJzTDadflQ2bLeM_C_UDSBmLxw</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Salem, Samira</creator><creator>Leghouchi, Essaid</creator><creator>Soulimani, Rachid</creator><creator>Bouayed, Jaouad</creator><general>Hogrefe</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-8410-2105</orcidid></search><sort><creationdate>202101</creationdate><title>Reduction of paw edema and liver oxidative stress in carrageenan-induced acute inflammation by Lobaria pulmonaria and Parmelia caperata , lichen species, in mice</title><author>Salem, Samira ; Leghouchi, Essaid ; Soulimani, Rachid ; Bouayed, Jaouad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-de50b61a3f6dcf92da2a4c8dae07bc1e6569767b48e013531c7c1bf9cb59118a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Ascomycota</topic><topic>Carrageenan - metabolism</topic><topic>Carrageenan - toxicity</topic><topic>Edema - chemically induced</topic><topic>Edema - drug therapy</topic><topic>Edema - metabolism</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - metabolism</topic><topic>Lichens</topic><topic>Life Sciences</topic><topic>Liver - metabolism</topic><topic>Mice</topic><topic>Oxidative Stress</topic><topic>Plant Extracts - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salem, Samira</creatorcontrib><creatorcontrib>Leghouchi, Essaid</creatorcontrib><creatorcontrib>Soulimani, Rachid</creatorcontrib><creatorcontrib>Bouayed, Jaouad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>International journal for vitamin and nutrition research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salem, Samira</au><au>Leghouchi, Essaid</au><au>Soulimani, Rachid</au><au>Bouayed, Jaouad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduction of paw edema and liver oxidative stress in carrageenan-induced acute inflammation by Lobaria pulmonaria and Parmelia caperata , lichen species, in mice</atitle><jtitle>International journal for vitamin and nutrition research</jtitle><addtitle>Int J Vitam Nutr Res</addtitle><date>2021-01</date><risdate>2021</risdate><volume>91</volume><issue>1-2</issue><spage>143</spage><epage>151</epage><pages>143-151</pages><issn>0300-9831</issn><eissn>1664-2821</eissn><abstract>Paw edema volume reduction is a useful marker in determining the anti-inflammatory effect of drugs and plant extracts in carrageenan-induced acute inflammation. In this study, the anti-inflammatory effect of
(LP) and
(PC), two lichen species, was examined in carrageenan-induced mouse paw edema test. Compared to the controls in carrageenan-induced inflammation (n = 5/group), our results showed that pretreatment by single oral doses with PC extract (50-500 mg/kg) gives better results than LP extract (50-500 mg/kg) in terms of anti-edematous activity, as after 4 h of carrageenan subplantar injection, paw edema formation was inhibited at 82-99% by PC while at 35-49% by LP. The higher anti-inflammatory effect of PC, at all doses, was also observed on the time-course of carrageenan-induced paw edema, displaying profile closely similar to that obtained with diclofenac (25 mg/kg), an anti-inflammatory drug reference (all
< 0.001). Both LP and PC, at all doses, significantly ameliorated liver catalase (CAT) activity (all
< 0.05). However, superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity and glutathione (GSH) levels were found increased in liver of PC- compared to LP-carrageenan-injected mice. Our findings demonstrated on one hand higher preventive effects of PC compared to LP in a mouse carrageenan-induced inflammatory model and suggested, on the other hand, that anti-inflammatory effects elicited by the two lichens were closely associated with the amelioration in the endogenous antioxidant status of liver.</abstract><cop>Switzerland</cop><pub>Hogrefe</pub><pmid>31847731</pmid><doi>10.1024/0300-9831/a000620</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8410-2105</orcidid></addata></record> |
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| subjects | Animals Ascomycota Carrageenan - metabolism Carrageenan - toxicity Edema - chemically induced Edema - drug therapy Edema - metabolism Inflammation - chemically induced Inflammation - drug therapy Inflammation - metabolism Lichens Life Sciences Liver - metabolism Mice Oxidative Stress Plant Extracts - pharmacology |
| title | Reduction of paw edema and liver oxidative stress in carrageenan-induced acute inflammation by Lobaria pulmonaria and Parmelia caperata , lichen species, in mice |
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