Cardiovascular outcomes in patients with cancer during a 5-year follow-up: Results from a French administrative database
•Patients with history of cancer had a higher incidence of death, MI and stroke.•In competing-risk analysis, death incidence was lower in patients with prior cancer.•Risk of myocardial infarction varied according to the organ locations of cancer. Limited data are available regarding the optimal mana...
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| Veröffentlicht in: | Archives of cardiovascular diseases 2023-02, Vol.116 (2), p.88-97 |
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| creator | Boyer, Jérémy Deharo, Pierre Angoulvant, Denis Ivanes, Fabrice Ferrara, Jerome Vaillier, Antoine Cautela, Jennifer Herbert, Julien Saint Etienne, Christophe Cuisset, Thomas Thuny, Franck Fauchier, Laurent |
| description | •Patients with history of cancer had a higher incidence of death, MI and stroke.•In competing-risk analysis, death incidence was lower in patients with prior cancer.•Risk of myocardial infarction varied according to the organ locations of cancer.
Limited data are available regarding the optimal management and prognosis of patients with cancer who develop an acute myocardial infarction.
The objective of this study was to analyse the characteristics and outcomes of patients according to cancer and myocardial infarction occurrence.
Based on the French administrative hospital discharge database, the study collected information for all consecutive patients seen in French hospitals in 2013, excluding those with a history of myocardial infarction. The population was divided into two groups according to their history of cancer. We studied the following outcomes: all-cause and cardiovascular mortality; acute myocardial infarction; and ischaemic stroke. Data were collected after a 5-year follow-up.
Between 2013 and 2019, 3,381,472 patients were seen in French hospitals; among them, 3,323,757 had no history of myocardial infarction. Patients with a history of cancer (n=497,593) had higher incidences of all-cause mortality (17.82%/year vs 3.79%/year), cardiovascular mortality (1.61%/year vs 1.17%/year), myocardial infarction (0.82%/year vs 0.61%/year) and ischaemic stroke (0.91%/year vs 0.62%/year) compared with patients without cancer (n=2,826,164). After performing an adjusted competing-risk analysis, the cumulative incidence of acute myocardial infarction, cardiovascular death and ischaemic stroke incidence was found to be lower in patients with a history of cancer, whereas death of non-cardiac origin was more prevalent in patients with a history of cancer.
In this observational study, we have shown that patients with cancer have a higher incidence of all-cause mortality, cardiovascular mortality and myocardial infarction. However, multivariable analysis showed a lower cumulative incidence of these events. |
| doi_str_mv | 10.1016/j.acvd.2022.11.006 |
| format | Article |
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Limited data are available regarding the optimal management and prognosis of patients with cancer who develop an acute myocardial infarction.
The objective of this study was to analyse the characteristics and outcomes of patients according to cancer and myocardial infarction occurrence.
Based on the French administrative hospital discharge database, the study collected information for all consecutive patients seen in French hospitals in 2013, excluding those with a history of myocardial infarction. The population was divided into two groups according to their history of cancer. We studied the following outcomes: all-cause and cardiovascular mortality; acute myocardial infarction; and ischaemic stroke. Data were collected after a 5-year follow-up.
Between 2013 and 2019, 3,381,472 patients were seen in French hospitals; among them, 3,323,757 had no history of myocardial infarction. Patients with a history of cancer (n=497,593) had higher incidences of all-cause mortality (17.82%/year vs 3.79%/year), cardiovascular mortality (1.61%/year vs 1.17%/year), myocardial infarction (0.82%/year vs 0.61%/year) and ischaemic stroke (0.91%/year vs 0.62%/year) compared with patients without cancer (n=2,826,164). After performing an adjusted competing-risk analysis, the cumulative incidence of acute myocardial infarction, cardiovascular death and ischaemic stroke incidence was found to be lower in patients with a history of cancer, whereas death of non-cardiac origin was more prevalent in patients with a history of cancer.
In this observational study, we have shown that patients with cancer have a higher incidence of all-cause mortality, cardiovascular mortality and myocardial infarction. However, multivariable analysis showed a lower cumulative incidence of these events.</description><identifier>ISSN: 1875-2136</identifier><identifier>EISSN: 1875-2128</identifier><identifier>DOI: 10.1016/j.acvd.2022.11.006</identifier><identifier>PMID: 36641244</identifier><language>eng</language><publisher>Netherlands: Elsevier Masson SAS</publisher><subject>Brain Ischemia ; Cancer ; Cardio-oncology ; Cardiology and cardiovascular system ; Coronary artery disease ; Human health and pathology ; Humans ; Ischemic Stroke ; Life Sciences ; Myocardial infarction ; Myocardial Infarction - diagnosis ; Myocardial Infarction - epidemiology ; Myocardial Infarction - therapy ; Neoplasms - diagnosis ; Neoplasms - epidemiology ; Risk Factors ; Stroke ; Stroke - diagnosis ; Stroke - epidemiology</subject><ispartof>Archives of cardiovascular diseases, 2023-02, Vol.116 (2), p.88-97</ispartof><rights>2023 Elsevier Masson SAS</rights><rights>Copyright © 2023 Elsevier Masson SAS. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c385t-e40a3fa4ed5a2c248313d922b7db400a80648540ce40f60e9e06ff69ae1068673</cites><orcidid>0000-0002-9267-1658 ; 0000-0003-0373-9591</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.acvd.2022.11.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,777,781,882,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36641244$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-04500073$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Boyer, Jérémy</creatorcontrib><creatorcontrib>Deharo, Pierre</creatorcontrib><creatorcontrib>Angoulvant, Denis</creatorcontrib><creatorcontrib>Ivanes, Fabrice</creatorcontrib><creatorcontrib>Ferrara, Jerome</creatorcontrib><creatorcontrib>Vaillier, Antoine</creatorcontrib><creatorcontrib>Cautela, Jennifer</creatorcontrib><creatorcontrib>Herbert, Julien</creatorcontrib><creatorcontrib>Saint Etienne, Christophe</creatorcontrib><creatorcontrib>Cuisset, Thomas</creatorcontrib><creatorcontrib>Thuny, Franck</creatorcontrib><creatorcontrib>Fauchier, Laurent</creatorcontrib><title>Cardiovascular outcomes in patients with cancer during a 5-year follow-up: Results from a French administrative database</title><title>Archives of cardiovascular diseases</title><addtitle>Arch Cardiovasc Dis</addtitle><description>•Patients with history of cancer had a higher incidence of death, MI and stroke.•In competing-risk analysis, death incidence was lower in patients with prior cancer.•Risk of myocardial infarction varied according to the organ locations of cancer.
Limited data are available regarding the optimal management and prognosis of patients with cancer who develop an acute myocardial infarction.
The objective of this study was to analyse the characteristics and outcomes of patients according to cancer and myocardial infarction occurrence.
Based on the French administrative hospital discharge database, the study collected information for all consecutive patients seen in French hospitals in 2013, excluding those with a history of myocardial infarction. The population was divided into two groups according to their history of cancer. We studied the following outcomes: all-cause and cardiovascular mortality; acute myocardial infarction; and ischaemic stroke. Data were collected after a 5-year follow-up.
Between 2013 and 2019, 3,381,472 patients were seen in French hospitals; among them, 3,323,757 had no history of myocardial infarction. Patients with a history of cancer (n=497,593) had higher incidences of all-cause mortality (17.82%/year vs 3.79%/year), cardiovascular mortality (1.61%/year vs 1.17%/year), myocardial infarction (0.82%/year vs 0.61%/year) and ischaemic stroke (0.91%/year vs 0.62%/year) compared with patients without cancer (n=2,826,164). After performing an adjusted competing-risk analysis, the cumulative incidence of acute myocardial infarction, cardiovascular death and ischaemic stroke incidence was found to be lower in patients with a history of cancer, whereas death of non-cardiac origin was more prevalent in patients with a history of cancer.
In this observational study, we have shown that patients with cancer have a higher incidence of all-cause mortality, cardiovascular mortality and myocardial infarction. However, multivariable analysis showed a lower cumulative incidence of these events.</description><subject>Brain Ischemia</subject><subject>Cancer</subject><subject>Cardio-oncology</subject><subject>Cardiology and cardiovascular system</subject><subject>Coronary artery disease</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Ischemic Stroke</subject><subject>Life Sciences</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - diagnosis</subject><subject>Myocardial Infarction - epidemiology</subject><subject>Myocardial Infarction - therapy</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - epidemiology</subject><subject>Risk Factors</subject><subject>Stroke</subject><subject>Stroke - diagnosis</subject><subject>Stroke - epidemiology</subject><issn>1875-2136</issn><issn>1875-2128</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhi0EoqXwAhyQj3BIsB3HziIu1Yq2SCshIThbs_aE9SqJF9tJ27fHq233yMkj6_s_jeYn5D1nNWdcfd7XYBdXCyZEzXnNmHpBLnmn20pw0b08z426IG9S2hdAaK1ek4tGKcmFlJfkYQ3R-bBAsvMAkYY52zBion6iB8gep5zovc87amGyGKmbo5_-UKBt9Ygl0IdhCPfVfPhCf2Kah4L3MYwFuIk42R0FN_rJpxyLbUHqIMMWEr4lr3oYEr57eq_I75tvv9Z31ebH7ff19aayTdfmCiWDpgeJrgVhhewa3riVEFvttpIx6JiSXSuZLWCvGK6Qqb5XK0DOVKd0c0U-nbw7GMwh-hHiowngzd31xhz_mGwZY7pZeGE_nthDDH9nTNmMPlkcBpgwzMkIrVqtywqrgooTamNIKWJ_dnNmju2YvTm2Y47tGM5NOX4JfXjyz9sR3TnyXEcBvp4ALBdZPEaTbKnAovMRbTYu-P_5_wHrLKCZ</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Boyer, Jérémy</creator><creator>Deharo, Pierre</creator><creator>Angoulvant, Denis</creator><creator>Ivanes, Fabrice</creator><creator>Ferrara, Jerome</creator><creator>Vaillier, Antoine</creator><creator>Cautela, Jennifer</creator><creator>Herbert, Julien</creator><creator>Saint Etienne, Christophe</creator><creator>Cuisset, Thomas</creator><creator>Thuny, Franck</creator><creator>Fauchier, Laurent</creator><general>Elsevier Masson SAS</general><general>Elsevier ; Société française de cardiologie [2008-....]</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-9267-1658</orcidid><orcidid>https://orcid.org/0000-0003-0373-9591</orcidid></search><sort><creationdate>202302</creationdate><title>Cardiovascular outcomes in patients with cancer during a 5-year follow-up: Results from a French administrative database</title><author>Boyer, Jérémy ; Deharo, Pierre ; Angoulvant, Denis ; Ivanes, Fabrice ; Ferrara, Jerome ; Vaillier, Antoine ; Cautela, Jennifer ; Herbert, Julien ; Saint Etienne, Christophe ; Cuisset, Thomas ; Thuny, Franck ; Fauchier, Laurent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-e40a3fa4ed5a2c248313d922b7db400a80648540ce40f60e9e06ff69ae1068673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Brain Ischemia</topic><topic>Cancer</topic><topic>Cardio-oncology</topic><topic>Cardiology and cardiovascular system</topic><topic>Coronary artery disease</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Ischemic Stroke</topic><topic>Life Sciences</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - diagnosis</topic><topic>Myocardial Infarction - epidemiology</topic><topic>Myocardial Infarction - therapy</topic><topic>Neoplasms - diagnosis</topic><topic>Neoplasms - epidemiology</topic><topic>Risk Factors</topic><topic>Stroke</topic><topic>Stroke - diagnosis</topic><topic>Stroke - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boyer, Jérémy</creatorcontrib><creatorcontrib>Deharo, Pierre</creatorcontrib><creatorcontrib>Angoulvant, Denis</creatorcontrib><creatorcontrib>Ivanes, Fabrice</creatorcontrib><creatorcontrib>Ferrara, Jerome</creatorcontrib><creatorcontrib>Vaillier, Antoine</creatorcontrib><creatorcontrib>Cautela, Jennifer</creatorcontrib><creatorcontrib>Herbert, Julien</creatorcontrib><creatorcontrib>Saint Etienne, Christophe</creatorcontrib><creatorcontrib>Cuisset, Thomas</creatorcontrib><creatorcontrib>Thuny, Franck</creatorcontrib><creatorcontrib>Fauchier, Laurent</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Archives of cardiovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boyer, Jérémy</au><au>Deharo, Pierre</au><au>Angoulvant, Denis</au><au>Ivanes, Fabrice</au><au>Ferrara, Jerome</au><au>Vaillier, Antoine</au><au>Cautela, Jennifer</au><au>Herbert, Julien</au><au>Saint Etienne, Christophe</au><au>Cuisset, Thomas</au><au>Thuny, Franck</au><au>Fauchier, Laurent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiovascular outcomes in patients with cancer during a 5-year follow-up: Results from a French administrative database</atitle><jtitle>Archives of cardiovascular diseases</jtitle><addtitle>Arch Cardiovasc Dis</addtitle><date>2023-02</date><risdate>2023</risdate><volume>116</volume><issue>2</issue><spage>88</spage><epage>97</epage><pages>88-97</pages><issn>1875-2136</issn><eissn>1875-2128</eissn><abstract>•Patients with history of cancer had a higher incidence of death, MI and stroke.•In competing-risk analysis, death incidence was lower in patients with prior cancer.•Risk of myocardial infarction varied according to the organ locations of cancer.
Limited data are available regarding the optimal management and prognosis of patients with cancer who develop an acute myocardial infarction.
The objective of this study was to analyse the characteristics and outcomes of patients according to cancer and myocardial infarction occurrence.
Based on the French administrative hospital discharge database, the study collected information for all consecutive patients seen in French hospitals in 2013, excluding those with a history of myocardial infarction. The population was divided into two groups according to their history of cancer. We studied the following outcomes: all-cause and cardiovascular mortality; acute myocardial infarction; and ischaemic stroke. Data were collected after a 5-year follow-up.
Between 2013 and 2019, 3,381,472 patients were seen in French hospitals; among them, 3,323,757 had no history of myocardial infarction. Patients with a history of cancer (n=497,593) had higher incidences of all-cause mortality (17.82%/year vs 3.79%/year), cardiovascular mortality (1.61%/year vs 1.17%/year), myocardial infarction (0.82%/year vs 0.61%/year) and ischaemic stroke (0.91%/year vs 0.62%/year) compared with patients without cancer (n=2,826,164). After performing an adjusted competing-risk analysis, the cumulative incidence of acute myocardial infarction, cardiovascular death and ischaemic stroke incidence was found to be lower in patients with a history of cancer, whereas death of non-cardiac origin was more prevalent in patients with a history of cancer.
In this observational study, we have shown that patients with cancer have a higher incidence of all-cause mortality, cardiovascular mortality and myocardial infarction. However, multivariable analysis showed a lower cumulative incidence of these events.</abstract><cop>Netherlands</cop><pub>Elsevier Masson SAS</pub><pmid>36641244</pmid><doi>10.1016/j.acvd.2022.11.006</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9267-1658</orcidid><orcidid>https://orcid.org/0000-0003-0373-9591</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Brain Ischemia Cancer Cardio-oncology Cardiology and cardiovascular system Coronary artery disease Human health and pathology Humans Ischemic Stroke Life Sciences Myocardial infarction Myocardial Infarction - diagnosis Myocardial Infarction - epidemiology Myocardial Infarction - therapy Neoplasms - diagnosis Neoplasms - epidemiology Risk Factors Stroke Stroke - diagnosis Stroke - epidemiology |
| title | Cardiovascular outcomes in patients with cancer during a 5-year follow-up: Results from a French administrative database |
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