Cross-talk between the proto-oncogenes Met and Ron

Scatter Factors control a complex genetic program known as 'invasive growth'. HGF (Scatter factor 1) and MSP (Scatter Factor 2) bind to tyrosine kinase receptors encoded by the proto-oncogenes MET and RON. Using the appropriate 'kinase inactive' mutant receptors, we show that lig...

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Veröffentlicht in:	Oncogene 2000-06, Vol.19 (27), p.3041-3049
Hauptverfasser:	FOLLENZI, A, BAKOVIC, S, GUAL, P, STELLA, M, LONGATI, P, COMOGLIO, P
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Biological and medical sciences Blotting, Western c-Met protein Cancer Cell physiology Cell surface Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes COS Cells Dimerization ErbB-1 protein ErbB-2 protein Fundamental and applied biological sciences. Psychology Gene Expression Regulation Growth factors Hepatocyte growth factor Intracellular signalling Kinases Life Sciences Ligands MET gene Metastasis Mice Molecular and cellular biology Mutagenesis, Site-Directed Mutants Mutation Phenotypes Phosphorylation Protein-tyrosine kinase Protein-Tyrosine Kinases Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins c-met Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism Proto-oncogenes Receptor Protein-Tyrosine Kinases Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Receptors, Cell Surface Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism RON gene Ron protein scatter factor receptors TrkA protein Tumor Cells, Cultured Tumors
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