Efficacy of tenofovir and efavirenz in combination with lamivudine or emtricitabine in antiretroviral-naive patients in Europe

Efficacy of tenofovir and efavirenz in combination with lamivudine or emtricitabine in antiretroviral-naive patients in Europe

The combination of tenofovir and efavirenz with either lamivudine or emtricitabine (TELE) has proved to be highly effective in clinical trials for first-line treatment of HIV-1 infection. However, limited data are available on its efficacy in routine clinical practice. A multicentre cohort study was...

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Veröffentlicht in:Journal of antimicrobial chemotherapy 2015-06, Vol.70 (6), p.1850-1857
Hauptverfasser: Swartz, J E, Vandekerckhove, L, Ammerlaan, H, de Vries, A C, Begovac, J, Bierman, W F W, Boucher, C A B, van der Ende, M E, Grossman, Z, Kaiser, R, Levy, I, Mudrikova, T, Paredes, R, Perez-Bercoff, D, Pronk, M, Richter, C, Schmit, J C, Vercauteren, J, Zazzi, M, Židovec Lepej, S, De Luca, A, Wensing, A M J
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Anti-Retroviral Agents - therapeutic use
Antiretroviral Therapy, Highly Active - methods
Clinical medicine
Clinical trials
Europe
Female
Genotype & phenotype
HIV
HIV Infections - drug therapy
HIV-1
Human immunodeficiency virus
Humans
Life Sciences
Male
Medical treatment
Middle Aged
Retrospective Studies
Toxicity
Treatment Outcome
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Zusammenfassung:The combination of tenofovir and efavirenz with either lamivudine or emtricitabine (TELE) has proved to be highly effective in clinical trials for first-line treatment of HIV-1 infection. However, limited data are available on its efficacy in routine clinical practice. A multicentre cohort study was performed in therapy-naive patients initiating ART with TELE before July 2009. Efficacy was studied using ITT (missing or switch = failure) and on-treatment (OT) analyses. Genotypic susceptibility scores (GSSs) were determined using the Stanford HIVdb algorithm. Efficacy analysis of 1608 patients showed virological suppression to
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkv033