Intratubular amyloid in light chain cast nephropathy is a risk factor for systemic light chain amyloidosis
Light chain cast nephropathy is the most common form of kidney disease in patients with multiple myeloma. Light chain casts may occasionally show amyloid staining properties, that is, green birefringence after Congo red staining. The frequency and clinical significance of this intratubular amyloid a...
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| Veröffentlicht in: | Modern pathology 2018-03, Vol.31 (3), p.452-462 |
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| creator | Gibier, Jean-Baptiste Gnemmi, Viviane Glowacki, François Boyle, Eileen M Lopez, Benjamin MacNamara, Evelyne Hoffmann, Maxime Azar, Raymond Guincestre, Thomas Bourdon, Franck Copin, Marie-Christine Buob, David |
| description | Light chain cast nephropathy is the most common form of kidney disease in patients with multiple myeloma. Light chain casts may occasionally show amyloid staining properties, that is, green birefringence after Congo red staining. The frequency and clinical significance of this intratubular amyloid are poorly understood. Here, we retrospectively assessed the clinicopathological features of 60 patients with histologically proven light chain cast nephropathy with a specific emphasis on intratubular amyloid, especially, its association with extrarenal systemic light chain amyloidosis. We found intratubular amyloid in 17 cases (17/60, 28%) and it was more frequent in patients with
λ
light chain gammopathy (13/17 in the 'intratubular amyloid' group
vs
19/43 in the 'no intratubular amyloid' group,
P
=0.02). Pathological examination of extrarenal specimens showed that intratubular amyloid was significantly associated with the occurrence of systemic light chain amyloidosis (5/13 in the 'intratubular amyloid' group
vs
0/30 in the 'no intratubular amyloid' group,
P
=0.001). Our results indicate that first, intratubular amyloid is not a rare finding in kidney biopsies of patients with light chain cast nephropathy, and, second, it reflects an amyloidogenic capacity of light chains that can manifest as systemic light chain amyloidosis. Thus, intratubular amyloid should be systematically screened for in kidney biopsies from patients with light chain cast nephropathy and, if detected, should prompt a work-up for associated systemic light chain amyloidosis. |
| doi_str_mv | 10.1038/modpathol.2017.124 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_04474897v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1954070883</sourcerecordid><originalsourceid>FETCH-LOGICAL-c545t-3d8b648bd521b35fa47e54e90d36f5962222a19bc43b8cdd8a130c49f3c23cdc3</originalsourceid><addsrcrecordid>eNp9kc1rHCEYxqUkNNu0_0AORcglOczGzxk9hpAvWMilPYujTsbNzLhVJ7D_fV12s6U9VBBf9Pc8r_oAcIHREiMqbsZgNzr3YVgShJslJuwTWGBOUYWI4CdggYSkFZWcnIEvKa0RwowL8hmcEYk4qRFegPXzlKPOczsPOkI9bofgLfQTHPxrn6HpdamNThlObtPHsGu4hT5BDaNPb7DTJocIuzLTNmU3evOX9OAYkk9fwWmnh-S-HdZz8PPh_sfdU7V6eXy-u11VhjOeK2pFWzPRWk5wS3mnWeM4cxJZWndc1qQMjWVrGG2FsVZoTJFhsqOGUGMNPQfXe99eD2oT_ajjVgXt1dPtSu32EGMNE7J5x4W92rObGH7NLmU1-mTcMOjJhTkpLDlDDRKCFvTyH3Qd5jiVl6jy_bjGhUGFInvKxJBSdN3xBhipXWrqmNpO1qiSWhF9P1jP7ejsUfIRUwHoHkjlaHp18U_v_9j-BoNGpug</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2011618330</pqid></control><display><type>article</type><title>Intratubular amyloid in light chain cast nephropathy is a risk factor for systemic light chain amyloidosis</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Gibier, Jean-Baptiste ; Gnemmi, Viviane ; Glowacki, François ; Boyle, Eileen M ; Lopez, Benjamin ; MacNamara, Evelyne ; Hoffmann, Maxime ; Azar, Raymond ; Guincestre, Thomas ; Bourdon, Franck ; Copin, Marie-Christine ; Buob, David</creator><creatorcontrib>Gibier, Jean-Baptiste ; Gnemmi, Viviane ; Glowacki, François ; Boyle, Eileen M ; Lopez, Benjamin ; MacNamara, Evelyne ; Hoffmann, Maxime ; Azar, Raymond ; Guincestre, Thomas ; Bourdon, Franck ; Copin, Marie-Christine ; Buob, David</creatorcontrib><description>Light chain cast nephropathy is the most common form of kidney disease in patients with multiple myeloma. Light chain casts may occasionally show amyloid staining properties, that is, green birefringence after Congo red staining. The frequency and clinical significance of this intratubular amyloid are poorly understood. Here, we retrospectively assessed the clinicopathological features of 60 patients with histologically proven light chain cast nephropathy with a specific emphasis on intratubular amyloid, especially, its association with extrarenal systemic light chain amyloidosis. We found intratubular amyloid in 17 cases (17/60, 28%) and it was more frequent in patients with
λ
light chain gammopathy (13/17 in the 'intratubular amyloid' group
vs
19/43 in the 'no intratubular amyloid' group,
P
=0.02). Pathological examination of extrarenal specimens showed that intratubular amyloid was significantly associated with the occurrence of systemic light chain amyloidosis (5/13 in the 'intratubular amyloid' group
vs
0/30 in the 'no intratubular amyloid' group,
P
=0.001). Our results indicate that first, intratubular amyloid is not a rare finding in kidney biopsies of patients with light chain cast nephropathy, and, second, it reflects an amyloidogenic capacity of light chains that can manifest as systemic light chain amyloidosis. Thus, intratubular amyloid should be systematically screened for in kidney biopsies from patients with light chain cast nephropathy and, if detected, should prompt a work-up for associated systemic light chain amyloidosis.</description><identifier>ISSN: 0893-3952</identifier><identifier>EISSN: 1530-0285</identifier><identifier>DOI: 10.1038/modpathol.2017.124</identifier><identifier>PMID: 29052601</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>13/51 ; 692/699/1541/1990/804 ; 692/699/1585/4 ; Adult ; Aged ; Aged, 80 and over ; Amyloid - analysis ; Amyloidogenesis ; Amyloidosis ; Biopsy ; Birefringence ; Female ; Gammopathy ; Humans ; Immunoglobulin Light-chain Amyloidosis - epidemiology ; Immunoglobulin Light-chain Amyloidosis - pathology ; Kidney Diseases - epidemiology ; Kidney Diseases - pathology ; Kidney Tubules - chemistry ; Kidney Tubules - pathology ; Kidneys ; Laboratory Medicine ; Life Sciences ; Light ; Light chains ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multiple myeloma ; Nephropathy ; original-article ; Pathology ; Retrospective Studies ; Risk Factors</subject><ispartof>Modern pathology, 2018-03, Vol.31 (3), p.452-462</ispartof><rights>United States & Canadian Academy of Pathology USCAP, Inc 2018</rights><rights>Copyright Nature Publishing Group Mar 2018</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c545t-3d8b648bd521b35fa47e54e90d36f5962222a19bc43b8cdd8a130c49f3c23cdc3</citedby><cites>FETCH-LOGICAL-c545t-3d8b648bd521b35fa47e54e90d36f5962222a19bc43b8cdd8a130c49f3c23cdc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29052601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.univ-lille.fr/hal-04474897$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Gibier, Jean-Baptiste</creatorcontrib><creatorcontrib>Gnemmi, Viviane</creatorcontrib><creatorcontrib>Glowacki, François</creatorcontrib><creatorcontrib>Boyle, Eileen M</creatorcontrib><creatorcontrib>Lopez, Benjamin</creatorcontrib><creatorcontrib>MacNamara, Evelyne</creatorcontrib><creatorcontrib>Hoffmann, Maxime</creatorcontrib><creatorcontrib>Azar, Raymond</creatorcontrib><creatorcontrib>Guincestre, Thomas</creatorcontrib><creatorcontrib>Bourdon, Franck</creatorcontrib><creatorcontrib>Copin, Marie-Christine</creatorcontrib><creatorcontrib>Buob, David</creatorcontrib><title>Intratubular amyloid in light chain cast nephropathy is a risk factor for systemic light chain amyloidosis</title><title>Modern pathology</title><addtitle>Mod Pathol</addtitle><addtitle>Mod Pathol</addtitle><description>Light chain cast nephropathy is the most common form of kidney disease in patients with multiple myeloma. Light chain casts may occasionally show amyloid staining properties, that is, green birefringence after Congo red staining. The frequency and clinical significance of this intratubular amyloid are poorly understood. Here, we retrospectively assessed the clinicopathological features of 60 patients with histologically proven light chain cast nephropathy with a specific emphasis on intratubular amyloid, especially, its association with extrarenal systemic light chain amyloidosis. We found intratubular amyloid in 17 cases (17/60, 28%) and it was more frequent in patients with
λ
light chain gammopathy (13/17 in the 'intratubular amyloid' group
vs
19/43 in the 'no intratubular amyloid' group,
P
=0.02). Pathological examination of extrarenal specimens showed that intratubular amyloid was significantly associated with the occurrence of systemic light chain amyloidosis (5/13 in the 'intratubular amyloid' group
vs
0/30 in the 'no intratubular amyloid' group,
P
=0.001). Our results indicate that first, intratubular amyloid is not a rare finding in kidney biopsies of patients with light chain cast nephropathy, and, second, it reflects an amyloidogenic capacity of light chains that can manifest as systemic light chain amyloidosis. Thus, intratubular amyloid should be systematically screened for in kidney biopsies from patients with light chain cast nephropathy and, if detected, should prompt a work-up for associated systemic light chain amyloidosis.</description><subject>13/51</subject><subject>692/699/1541/1990/804</subject><subject>692/699/1585/4</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amyloid - analysis</subject><subject>Amyloidogenesis</subject><subject>Amyloidosis</subject><subject>Biopsy</subject><subject>Birefringence</subject><subject>Female</subject><subject>Gammopathy</subject><subject>Humans</subject><subject>Immunoglobulin Light-chain Amyloidosis - epidemiology</subject><subject>Immunoglobulin Light-chain Amyloidosis - pathology</subject><subject>Kidney Diseases - epidemiology</subject><subject>Kidney Diseases - pathology</subject><subject>Kidney Tubules - chemistry</subject><subject>Kidney Tubules - pathology</subject><subject>Kidneys</subject><subject>Laboratory Medicine</subject><subject>Life Sciences</subject><subject>Light</subject><subject>Light chains</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multiple myeloma</subject><subject>Nephropathy</subject><subject>original-article</subject><subject>Pathology</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><issn>0893-3952</issn><issn>1530-0285</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc1rHCEYxqUkNNu0_0AORcglOczGzxk9hpAvWMilPYujTsbNzLhVJ7D_fV12s6U9VBBf9Pc8r_oAcIHREiMqbsZgNzr3YVgShJslJuwTWGBOUYWI4CdggYSkFZWcnIEvKa0RwowL8hmcEYk4qRFegPXzlKPOczsPOkI9bofgLfQTHPxrn6HpdamNThlObtPHsGu4hT5BDaNPb7DTJocIuzLTNmU3evOX9OAYkk9fwWmnh-S-HdZz8PPh_sfdU7V6eXy-u11VhjOeK2pFWzPRWk5wS3mnWeM4cxJZWndc1qQMjWVrGG2FsVZoTJFhsqOGUGMNPQfXe99eD2oT_ajjVgXt1dPtSu32EGMNE7J5x4W92rObGH7NLmU1-mTcMOjJhTkpLDlDDRKCFvTyH3Qd5jiVl6jy_bjGhUGFInvKxJBSdN3xBhipXWrqmNpO1qiSWhF9P1jP7ejsUfIRUwHoHkjlaHp18U_v_9j-BoNGpug</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Gibier, Jean-Baptiste</creator><creator>Gnemmi, Viviane</creator><creator>Glowacki, François</creator><creator>Boyle, Eileen M</creator><creator>Lopez, Benjamin</creator><creator>MacNamara, Evelyne</creator><creator>Hoffmann, Maxime</creator><creator>Azar, Raymond</creator><creator>Guincestre, Thomas</creator><creator>Bourdon, Franck</creator><creator>Copin, Marie-Christine</creator><creator>Buob, David</creator><general>Nature Publishing Group US</general><general>Elsevier Limited</general><general>Nature Publishing Group: Open Access Hybrid Model Option B</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>20180301</creationdate><title>Intratubular amyloid in light chain cast nephropathy is a risk factor for systemic light chain amyloidosis</title><author>Gibier, Jean-Baptiste ; Gnemmi, Viviane ; Glowacki, François ; Boyle, Eileen M ; Lopez, Benjamin ; MacNamara, Evelyne ; Hoffmann, Maxime ; Azar, Raymond ; Guincestre, Thomas ; Bourdon, Franck ; Copin, Marie-Christine ; Buob, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c545t-3d8b648bd521b35fa47e54e90d36f5962222a19bc43b8cdd8a130c49f3c23cdc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>13/51</topic><topic>692/699/1541/1990/804</topic><topic>692/699/1585/4</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amyloid - analysis</topic><topic>Amyloidogenesis</topic><topic>Amyloidosis</topic><topic>Biopsy</topic><topic>Birefringence</topic><topic>Female</topic><topic>Gammopathy</topic><topic>Humans</topic><topic>Immunoglobulin Light-chain Amyloidosis - epidemiology</topic><topic>Immunoglobulin Light-chain Amyloidosis - pathology</topic><topic>Kidney Diseases - epidemiology</topic><topic>Kidney Diseases - pathology</topic><topic>Kidney Tubules - chemistry</topic><topic>Kidney Tubules - pathology</topic><topic>Kidneys</topic><topic>Laboratory Medicine</topic><topic>Life Sciences</topic><topic>Light</topic><topic>Light chains</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multiple myeloma</topic><topic>Nephropathy</topic><topic>original-article</topic><topic>Pathology</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gibier, Jean-Baptiste</creatorcontrib><creatorcontrib>Gnemmi, Viviane</creatorcontrib><creatorcontrib>Glowacki, François</creatorcontrib><creatorcontrib>Boyle, Eileen M</creatorcontrib><creatorcontrib>Lopez, Benjamin</creatorcontrib><creatorcontrib>MacNamara, Evelyne</creatorcontrib><creatorcontrib>Hoffmann, Maxime</creatorcontrib><creatorcontrib>Azar, Raymond</creatorcontrib><creatorcontrib>Guincestre, Thomas</creatorcontrib><creatorcontrib>Bourdon, Franck</creatorcontrib><creatorcontrib>Copin, Marie-Christine</creatorcontrib><creatorcontrib>Buob, David</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Modern pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gibier, Jean-Baptiste</au><au>Gnemmi, Viviane</au><au>Glowacki, François</au><au>Boyle, Eileen M</au><au>Lopez, Benjamin</au><au>MacNamara, Evelyne</au><au>Hoffmann, Maxime</au><au>Azar, Raymond</au><au>Guincestre, Thomas</au><au>Bourdon, Franck</au><au>Copin, Marie-Christine</au><au>Buob, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intratubular amyloid in light chain cast nephropathy is a risk factor for systemic light chain amyloidosis</atitle><jtitle>Modern pathology</jtitle><stitle>Mod Pathol</stitle><addtitle>Mod Pathol</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>31</volume><issue>3</issue><spage>452</spage><epage>462</epage><pages>452-462</pages><issn>0893-3952</issn><eissn>1530-0285</eissn><abstract>Light chain cast nephropathy is the most common form of kidney disease in patients with multiple myeloma. Light chain casts may occasionally show amyloid staining properties, that is, green birefringence after Congo red staining. The frequency and clinical significance of this intratubular amyloid are poorly understood. Here, we retrospectively assessed the clinicopathological features of 60 patients with histologically proven light chain cast nephropathy with a specific emphasis on intratubular amyloid, especially, its association with extrarenal systemic light chain amyloidosis. We found intratubular amyloid in 17 cases (17/60, 28%) and it was more frequent in patients with
λ
light chain gammopathy (13/17 in the 'intratubular amyloid' group
vs
19/43 in the 'no intratubular amyloid' group,
P
=0.02). Pathological examination of extrarenal specimens showed that intratubular amyloid was significantly associated with the occurrence of systemic light chain amyloidosis (5/13 in the 'intratubular amyloid' group
vs
0/30 in the 'no intratubular amyloid' group,
P
=0.001). Our results indicate that first, intratubular amyloid is not a rare finding in kidney biopsies of patients with light chain cast nephropathy, and, second, it reflects an amyloidogenic capacity of light chains that can manifest as systemic light chain amyloidosis. Thus, intratubular amyloid should be systematically screened for in kidney biopsies from patients with light chain cast nephropathy and, if detected, should prompt a work-up for associated systemic light chain amyloidosis.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>29052601</pmid><doi>10.1038/modpathol.2017.124</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Modern pathology, 2018-03, Vol.31 (3), p.452-462 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | 13/51 692/699/1541/1990/804 692/699/1585/4 Adult Aged Aged, 80 and over Amyloid - analysis Amyloidogenesis Amyloidosis Biopsy Birefringence Female Gammopathy Humans Immunoglobulin Light-chain Amyloidosis - epidemiology Immunoglobulin Light-chain Amyloidosis - pathology Kidney Diseases - epidemiology Kidney Diseases - pathology Kidney Tubules - chemistry Kidney Tubules - pathology Kidneys Laboratory Medicine Life Sciences Light Light chains Male Medicine Medicine & Public Health Middle Aged Multiple myeloma Nephropathy original-article Pathology Retrospective Studies Risk Factors |
| title | Intratubular amyloid in light chain cast nephropathy is a risk factor for systemic light chain amyloidosis |
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