CT Imaging Assessment of Response to Treatment in Allergic Bronchopulmonary Aspergillosis in Adults With Bronchial Asthma
One of the major challenges in managing allergic bronchopulmonary aspergillosis remains consistent and reproducible assessment of response to treatment. What are the most relevant changes in CT scan parameters over time for assessing response to treatment? In this ancillary study of a randomized cli...
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| creator | Godet, Cendrine Brun, Anne-Laure Couturaud, Francis Laurent, François Frat, Jean-Pierre Marchand-Adam, Sylvain Gagnadoux, Frédéric Blanchard, Elodie Taillé, Camille Philippe, Bruno Hirschi, Sandrine Andréjak, Claire Bourdin, Arnaud Chenivesse, Cécile Dominique, Stéphane Mangiapan, Gilles Murris-Espin, Marlène Rivière, Frédéric Garcia, Gilles Blanc, François-Xavier Goupil, François Bergeron, Anne Flament, Thomas Priou, Pascaline Mal, Hervé de Keizer, Joe Ragot, Stéphanie Cadranel, Jacques Mal, Hervé Le Guen, Pierre Dupin, Clairelyne Meurice, Jean Claude Verdaguer, Marion de Keizer, Joe Delétage-Métreau, Céline Le Mao, Raphael Tromer, Cécile Fajole, Gaëlle Rayez, Mélanie Raymond, Christel Saint Gheerbrant, Hubert Badatcheff, Anne Person, Christine Macey, Julie Dermant, Xavier Boitiaux, Jean-François Gosset-Woimant, Marine Metz-Favre, Carine Degot, Tristan Poulet, Claire Popin, Elisabeth Gamez, Anne Sophie Boissin, Clément Prevotat, Anne Mangiapan, Gilles Brouquières, Danielle Le Floch, Hervé Morisse-Pradier, Hélène Sattler, Caroline Muti, Daniela Germaud, Patrick Dirou, Stéphanie Paris, Audrey Melloni, Boris Ballouhey, Julia Bondeelle, Louise Laurent, Lucie Belleguic, Chantal Kerjouan, Mallorie Deslée, Gaëtan Dury, Sandra Bergot, Emmanuel Magnier, Romain Morel, Hugues Lemaire, Bertrand Tumino, Cécile Sénéchal, Agathe Choinier, Pascaline Parrot, Antoine |
| description | One of the major challenges in managing allergic bronchopulmonary aspergillosis remains consistent and reproducible assessment of response to treatment.
What are the most relevant changes in CT scan parameters over time for assessing response to treatment?
In this ancillary study of a randomized clinical trial (NebuLamB), patients with asthma with available CT scan and without exacerbation during a 4-month allergic bronchopulmonary aspergillosis exacerbation treatment period (corticosteroids and itraconazole) were included. Changed CT scan parameters were assessed by systematic analyses of CT scan findings at initiation and end of treatment. CT scans were assessed by two radiologists anonymized to the clinical data. Radiologic parameters were determined by selecting those showing significant changes over time. Improvement of at least one, without worsening of the others, defined the radiologic response. Agreement between radiologic changes and clinical and immunologic responses was likewise investigated.
Among the 139 originally randomized patients, 132 were included. We identified five CT scan parameters showing significant changes at end of treatment: mucoid impaction extent, mucoid impaction density, centrilobular micronodules, consolidation/ground-glass opacities, and bronchial wall thickening (P < .05). These changes were only weakly associated with one another, except for mucoid impaction extent and density. No agreement was observed between clinical, immunologic, and radiologic responses, assessed as an overall response, or considering each of the parameters (Cohen κ, −0.01 to 0.24).
Changes in extent and density of mucoid impaction, centrilobular micronodules, consolidation/ground-glass opacities, and thickening of the bronchial walls were found to be the most relevant CT scan parameters to assess radiologic response to treatment. A clinical, immunologic, and radiologic multidimensional approach should be adopted to assess outcomes, probably with a composite definition of response to treatment.
ClinicalTrials.gov; No.: NCT02273661; URL: www.clinicaltrials.gov) |
| doi_str_mv | 10.1016/j.chest.2024.02.026 |
| format | Article |
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What are the most relevant changes in CT scan parameters over time for assessing response to treatment?
In this ancillary study of a randomized clinical trial (NebuLamB), patients with asthma with available CT scan and without exacerbation during a 4-month allergic bronchopulmonary aspergillosis exacerbation treatment period (corticosteroids and itraconazole) were included. Changed CT scan parameters were assessed by systematic analyses of CT scan findings at initiation and end of treatment. CT scans were assessed by two radiologists anonymized to the clinical data. Radiologic parameters were determined by selecting those showing significant changes over time. Improvement of at least one, without worsening of the others, defined the radiologic response. Agreement between radiologic changes and clinical and immunologic responses was likewise investigated.
Among the 139 originally randomized patients, 132 were included. We identified five CT scan parameters showing significant changes at end of treatment: mucoid impaction extent, mucoid impaction density, centrilobular micronodules, consolidation/ground-glass opacities, and bronchial wall thickening (P < .05). These changes were only weakly associated with one another, except for mucoid impaction extent and density. No agreement was observed between clinical, immunologic, and radiologic responses, assessed as an overall response, or considering each of the parameters (Cohen κ, −0.01 to 0.24).
Changes in extent and density of mucoid impaction, centrilobular micronodules, consolidation/ground-glass opacities, and thickening of the bronchial walls were found to be the most relevant CT scan parameters to assess radiologic response to treatment. A clinical, immunologic, and radiologic multidimensional approach should be adopted to assess outcomes, probably with a composite definition of response to treatment.
ClinicalTrials.gov; No.: NCT02273661; URL: www.clinicaltrials.gov)</description><identifier>ISSN: 0012-3692</identifier><identifier>ISSN: 1931-3543</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1016/j.chest.2024.02.026</identifier><identifier>PMID: 38387646</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>ABPA ; Adrenal Cortex Hormones / therapeutic use ; Adult ; allergic bronchopulmonary aspergillosis ; Antifungal Agents / therapeutic use ; Aspergillosis, Allergic Bronchopulmonary / diagnostic imaging ; Aspergillosis, Allergic Bronchopulmonary / drug therapy ; Asthma / diagnostic imaging ; Asthma / drug therapy ; CT scan ; Female ; Human health and pathology ; Humans ; Itraconazole / therapeutic use ; Life Sciences ; Male ; Middle Aged ; radiologic response ; Tomography, X-Ray Computed / methods ; Treatment Outcome ; treatment outcomes</subject><ispartof>Chest, 2024-06, Vol.165 (6), p.1307-1318</ispartof><rights>2024 American College of Chest Physicians</rights><rights>Copyright © 2024 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c343t-575af90e12610b9d974169a31ef7f8e13330c920f4d0b7089b70b244a2766e643</cites><orcidid>0000-0002-6229-2075 ; 0000-0002-9176-7797 ; 0000-0002-2346-3265 ; 0000-0002-5245-8537 ; 0000-0003-2156-254X ; 0000-0001-7644-2188 ; 0000-0002-9627-3016 ; 0000-0002-5871-7886 ; 0000-0002-4231-5102 ; 0000-0001-5445-9122 ; 0000-0002-1855-8032 ; 0000-0002-9998-8578 ; 0000-0002-2874-0655</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38387646$$D View this record in 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Hervé</creatorcontrib><creatorcontrib>Morisse-Pradier, Hélène</creatorcontrib><creatorcontrib>Sattler, Caroline</creatorcontrib><creatorcontrib>Muti, Daniela</creatorcontrib><creatorcontrib>Germaud, Patrick</creatorcontrib><creatorcontrib>Dirou, Stéphanie</creatorcontrib><creatorcontrib>Paris, Audrey</creatorcontrib><creatorcontrib>Melloni, Boris</creatorcontrib><creatorcontrib>Ballouhey, Julia</creatorcontrib><creatorcontrib>Bondeelle, Louise</creatorcontrib><creatorcontrib>Laurent, Lucie</creatorcontrib><creatorcontrib>Belleguic, Chantal</creatorcontrib><creatorcontrib>Kerjouan, Mallorie</creatorcontrib><creatorcontrib>Deslée, Gaëtan</creatorcontrib><creatorcontrib>Dury, Sandra</creatorcontrib><creatorcontrib>Bergot, Emmanuel</creatorcontrib><creatorcontrib>Magnier, Romain</creatorcontrib><creatorcontrib>Morel, Hugues</creatorcontrib><creatorcontrib>Lemaire, Bertrand</creatorcontrib><creatorcontrib>Tumino, Cécile</creatorcontrib><creatorcontrib>Sénéchal, Agathe</creatorcontrib><creatorcontrib>Choinier, Pascaline</creatorcontrib><creatorcontrib>Parrot, Antoine</creatorcontrib><creatorcontrib>NebuLamB Study Group and GREPI Network</creatorcontrib><title>CT Imaging Assessment of Response to Treatment in Allergic Bronchopulmonary Aspergillosis in Adults With Bronchial Asthma</title><title>Chest</title><addtitle>Chest</addtitle><description>One of the major challenges in managing allergic bronchopulmonary aspergillosis remains consistent and reproducible assessment of response to treatment.
What are the most relevant changes in CT scan parameters over time for assessing response to treatment?
In this ancillary study of a randomized clinical trial (NebuLamB), patients with asthma with available CT scan and without exacerbation during a 4-month allergic bronchopulmonary aspergillosis exacerbation treatment period (corticosteroids and itraconazole) were included. Changed CT scan parameters were assessed by systematic analyses of CT scan findings at initiation and end of treatment. CT scans were assessed by two radiologists anonymized to the clinical data. Radiologic parameters were determined by selecting those showing significant changes over time. Improvement of at least one, without worsening of the others, defined the radiologic response. Agreement between radiologic changes and clinical and immunologic responses was likewise investigated.
Among the 139 originally randomized patients, 132 were included. We identified five CT scan parameters showing significant changes at end of treatment: mucoid impaction extent, mucoid impaction density, centrilobular micronodules, consolidation/ground-glass opacities, and bronchial wall thickening (P < .05). These changes were only weakly associated with one another, except for mucoid impaction extent and density. No agreement was observed between clinical, immunologic, and radiologic responses, assessed as an overall response, or considering each of the parameters (Cohen κ, −0.01 to 0.24).
Changes in extent and density of mucoid impaction, centrilobular micronodules, consolidation/ground-glass opacities, and thickening of the bronchial walls were found to be the most relevant CT scan parameters to assess radiologic response to treatment. A clinical, immunologic, and radiologic multidimensional approach should be adopted to assess outcomes, probably with a composite definition of response to treatment.
ClinicalTrials.gov; No.: NCT02273661; URL: www.clinicaltrials.gov)</description><subject>ABPA</subject><subject>Adrenal Cortex Hormones / therapeutic use</subject><subject>Adult</subject><subject>allergic bronchopulmonary aspergillosis</subject><subject>Antifungal Agents / therapeutic use</subject><subject>Aspergillosis, Allergic Bronchopulmonary / diagnostic imaging</subject><subject>Aspergillosis, Allergic Bronchopulmonary / drug therapy</subject><subject>Asthma / diagnostic imaging</subject><subject>Asthma / drug therapy</subject><subject>CT scan</subject><subject>Female</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Itraconazole / therapeutic use</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Middle Aged</subject><subject>radiologic response</subject><subject>Tomography, X-Ray Computed / methods</subject><subject>Treatment Outcome</subject><subject>treatment 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Aspergillosis in Adults With Bronchial Asthma</title><author>Godet, Cendrine ; Brun, Anne-Laure ; Couturaud, Francis ; Laurent, François ; Frat, Jean-Pierre ; Marchand-Adam, Sylvain ; Gagnadoux, Frédéric ; Blanchard, Elodie ; Taillé, Camille ; Philippe, Bruno ; Hirschi, Sandrine ; Andréjak, Claire ; Bourdin, Arnaud ; Chenivesse, Cécile ; Dominique, Stéphane ; Mangiapan, Gilles ; Murris-Espin, Marlène ; Rivière, Frédéric ; Garcia, Gilles ; Blanc, François-Xavier ; Goupil, François ; Bergeron, Anne ; Flament, Thomas ; Priou, Pascaline ; Mal, Hervé ; de Keizer, Joe ; Ragot, Stéphanie ; Cadranel, Jacques ; Mal, Hervé ; Le Guen, Pierre ; Dupin, Clairelyne ; Meurice, Jean Claude ; Verdaguer, Marion ; de Keizer, Joe ; Delétage-Métreau, Céline ; Le Mao, Raphael ; Tromer, Cécile ; Fajole, Gaëlle ; Rayez, Mélanie ; Raymond, Christel Saint ; Gheerbrant, Hubert ; Badatcheff, Anne ; Person, Christine ; Macey, Julie ; Dermant, Xavier ; Boitiaux, Jean-François ; Gosset-Woimant, Marine ; Metz-Favre, Carine ; Degot, Tristan ; Poulet, Claire ; Popin, Elisabeth ; Gamez, Anne Sophie ; Boissin, Clément ; Prevotat, Anne ; Mangiapan, Gilles ; Brouquières, Danielle ; Le Floch, Hervé ; Morisse-Pradier, Hélène ; Sattler, Caroline ; Muti, Daniela ; Germaud, Patrick ; Dirou, Stéphanie ; Paris, Audrey ; Melloni, Boris ; Ballouhey, Julia ; Bondeelle, Louise ; Laurent, Lucie ; Belleguic, Chantal ; Kerjouan, Mallorie ; Deslée, Gaëtan ; Dury, Sandra ; Bergot, Emmanuel ; Magnier, Romain ; Morel, Hugues ; Lemaire, Bertrand ; Tumino, Cécile ; Sénéchal, Agathe ; Choinier, Pascaline ; Parrot, Antoine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-575af90e12610b9d974169a31ef7f8e13330c920f4d0b7089b70b244a2766e643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>ABPA</topic><topic>Adrenal Cortex Hormones / therapeutic use</topic><topic>Adult</topic><topic>allergic bronchopulmonary aspergillosis</topic><topic>Antifungal Agents / therapeutic use</topic><topic>Aspergillosis, Allergic Bronchopulmonary / diagnostic imaging</topic><topic>Aspergillosis, Allergic Bronchopulmonary / drug therapy</topic><topic>Asthma / diagnostic imaging</topic><topic>Asthma / drug therapy</topic><topic>CT scan</topic><topic>Female</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Itraconazole / therapeutic use</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Middle Aged</topic><topic>radiologic response</topic><topic>Tomography, X-Ray Computed / methods</topic><topic>Treatment Outcome</topic><topic>treatment outcomes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Godet, Cendrine</creatorcontrib><creatorcontrib>Brun, Anne-Laure</creatorcontrib><creatorcontrib>Couturaud, Francis</creatorcontrib><creatorcontrib>Laurent, François</creatorcontrib><creatorcontrib>Frat, 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Hervé</creatorcontrib><creatorcontrib>de Keizer, Joe</creatorcontrib><creatorcontrib>Ragot, Stéphanie</creatorcontrib><creatorcontrib>Cadranel, Jacques</creatorcontrib><creatorcontrib>Mal, Hervé</creatorcontrib><creatorcontrib>Le Guen, Pierre</creatorcontrib><creatorcontrib>Dupin, Clairelyne</creatorcontrib><creatorcontrib>Meurice, Jean Claude</creatorcontrib><creatorcontrib>Verdaguer, Marion</creatorcontrib><creatorcontrib>de Keizer, Joe</creatorcontrib><creatorcontrib>Delétage-Métreau, Céline</creatorcontrib><creatorcontrib>Le Mao, Raphael</creatorcontrib><creatorcontrib>Tromer, Cécile</creatorcontrib><creatorcontrib>Fajole, Gaëlle</creatorcontrib><creatorcontrib>Rayez, Mélanie</creatorcontrib><creatorcontrib>Raymond, Christel Saint</creatorcontrib><creatorcontrib>Gheerbrant, Hubert</creatorcontrib><creatorcontrib>Badatcheff, Anne</creatorcontrib><creatorcontrib>Person, Christine</creatorcontrib><creatorcontrib>Macey, Julie</creatorcontrib><creatorcontrib>Dermant, Xavier</creatorcontrib><creatorcontrib>Boitiaux, Jean-François</creatorcontrib><creatorcontrib>Gosset-Woimant, Marine</creatorcontrib><creatorcontrib>Metz-Favre, Carine</creatorcontrib><creatorcontrib>Degot, Tristan</creatorcontrib><creatorcontrib>Poulet, Claire</creatorcontrib><creatorcontrib>Popin, Elisabeth</creatorcontrib><creatorcontrib>Gamez, Anne Sophie</creatorcontrib><creatorcontrib>Boissin, Clément</creatorcontrib><creatorcontrib>Prevotat, Anne</creatorcontrib><creatorcontrib>Mangiapan, Gilles</creatorcontrib><creatorcontrib>Brouquières, Danielle</creatorcontrib><creatorcontrib>Le Floch, Hervé</creatorcontrib><creatorcontrib>Morisse-Pradier, Hélène</creatorcontrib><creatorcontrib>Sattler, Caroline</creatorcontrib><creatorcontrib>Muti, Daniela</creatorcontrib><creatorcontrib>Germaud, Patrick</creatorcontrib><creatorcontrib>Dirou, Stéphanie</creatorcontrib><creatorcontrib>Paris, Audrey</creatorcontrib><creatorcontrib>Melloni, Boris</creatorcontrib><creatorcontrib>Ballouhey, Julia</creatorcontrib><creatorcontrib>Bondeelle, Louise</creatorcontrib><creatorcontrib>Laurent, Lucie</creatorcontrib><creatorcontrib>Belleguic, Chantal</creatorcontrib><creatorcontrib>Kerjouan, Mallorie</creatorcontrib><creatorcontrib>Deslée, Gaëtan</creatorcontrib><creatorcontrib>Dury, Sandra</creatorcontrib><creatorcontrib>Bergot, Emmanuel</creatorcontrib><creatorcontrib>Magnier, Romain</creatorcontrib><creatorcontrib>Morel, Hugues</creatorcontrib><creatorcontrib>Lemaire, Bertrand</creatorcontrib><creatorcontrib>Tumino, Cécile</creatorcontrib><creatorcontrib>Sénéchal, Agathe</creatorcontrib><creatorcontrib>Choinier, Pascaline</creatorcontrib><creatorcontrib>Parrot, Antoine</creatorcontrib><creatorcontrib>NebuLamB Study Group and GREPI Network</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Godet, Cendrine</au><au>Brun, Anne-Laure</au><au>Couturaud, Francis</au><au>Laurent, François</au><au>Frat, Jean-Pierre</au><au>Marchand-Adam, Sylvain</au><au>Gagnadoux, Frédéric</au><au>Blanchard, Elodie</au><au>Taillé, Camille</au><au>Philippe, Bruno</au><au>Hirschi, Sandrine</au><au>Andréjak, Claire</au><au>Bourdin, Arnaud</au><au>Chenivesse, Cécile</au><au>Dominique, Stéphane</au><au>Mangiapan, Gilles</au><au>Murris-Espin, Marlène</au><au>Rivière, Frédéric</au><au>Garcia, Gilles</au><au>Blanc, François-Xavier</au><au>Goupil, François</au><au>Bergeron, Anne</au><au>Flament, Thomas</au><au>Priou, Pascaline</au><au>Mal, Hervé</au><au>de Keizer, Joe</au><au>Ragot, Stéphanie</au><au>Cadranel, Jacques</au><au>Mal, Hervé</au><au>Le Guen, Pierre</au><au>Dupin, Clairelyne</au><au>Meurice, Jean Claude</au><au>Verdaguer, Marion</au><au>de Keizer, Joe</au><au>Delétage-Métreau, Céline</au><au>Le Mao, Raphael</au><au>Tromer, Cécile</au><au>Fajole, Gaëlle</au><au>Rayez, Mélanie</au><au>Raymond, Christel Saint</au><au>Gheerbrant, Hubert</au><au>Badatcheff, Anne</au><au>Person, Christine</au><au>Macey, Julie</au><au>Dermant, Xavier</au><au>Boitiaux, Jean-François</au><au>Gosset-Woimant, Marine</au><au>Metz-Favre, Carine</au><au>Degot, Tristan</au><au>Poulet, Claire</au><au>Popin, Elisabeth</au><au>Gamez, Anne Sophie</au><au>Boissin, Clément</au><au>Prevotat, Anne</au><au>Mangiapan, Gilles</au><au>Brouquières, Danielle</au><au>Le Floch, Hervé</au><au>Morisse-Pradier, Hélène</au><au>Sattler, Caroline</au><au>Muti, Daniela</au><au>Germaud, Patrick</au><au>Dirou, Stéphanie</au><au>Paris, Audrey</au><au>Melloni, Boris</au><au>Ballouhey, Julia</au><au>Bondeelle, Louise</au><au>Laurent, Lucie</au><au>Belleguic, Chantal</au><au>Kerjouan, Mallorie</au><au>Deslée, Gaëtan</au><au>Dury, Sandra</au><au>Bergot, Emmanuel</au><au>Magnier, Romain</au><au>Morel, Hugues</au><au>Lemaire, Bertrand</au><au>Tumino, Cécile</au><au>Sénéchal, Agathe</au><au>Choinier, Pascaline</au><au>Parrot, Antoine</au><aucorp>NebuLamB Study Group and GREPI Network</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CT Imaging Assessment of Response to Treatment in Allergic Bronchopulmonary Aspergillosis in Adults With Bronchial Asthma</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>165</volume><issue>6</issue><spage>1307</spage><epage>1318</epage><pages>1307-1318</pages><issn>0012-3692</issn><issn>1931-3543</issn><eissn>1931-3543</eissn><abstract>One of the major challenges in managing allergic bronchopulmonary aspergillosis remains consistent and reproducible assessment of response to treatment.
What are the most relevant changes in CT scan parameters over time for assessing response to treatment?
In this ancillary study of a randomized clinical trial (NebuLamB), patients with asthma with available CT scan and without exacerbation during a 4-month allergic bronchopulmonary aspergillosis exacerbation treatment period (corticosteroids and itraconazole) were included. Changed CT scan parameters were assessed by systematic analyses of CT scan findings at initiation and end of treatment. CT scans were assessed by two radiologists anonymized to the clinical data. Radiologic parameters were determined by selecting those showing significant changes over time. Improvement of at least one, without worsening of the others, defined the radiologic response. Agreement between radiologic changes and clinical and immunologic responses was likewise investigated.
Among the 139 originally randomized patients, 132 were included. We identified five CT scan parameters showing significant changes at end of treatment: mucoid impaction extent, mucoid impaction density, centrilobular micronodules, consolidation/ground-glass opacities, and bronchial wall thickening (P < .05). These changes were only weakly associated with one another, except for mucoid impaction extent and density. No agreement was observed between clinical, immunologic, and radiologic responses, assessed as an overall response, or considering each of the parameters (Cohen κ, −0.01 to 0.24).
Changes in extent and density of mucoid impaction, centrilobular micronodules, consolidation/ground-glass opacities, and thickening of the bronchial walls were found to be the most relevant CT scan parameters to assess radiologic response to treatment. A clinical, immunologic, and radiologic multidimensional approach should be adopted to assess outcomes, probably with a composite definition of response to treatment.
ClinicalTrials.gov; No.: NCT02273661; URL: www.clinicaltrials.gov)</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>38387646</pmid><doi>10.1016/j.chest.2024.02.026</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-6229-2075</orcidid><orcidid>https://orcid.org/0000-0002-9176-7797</orcidid><orcidid>https://orcid.org/0000-0002-2346-3265</orcidid><orcidid>https://orcid.org/0000-0002-5245-8537</orcidid><orcidid>https://orcid.org/0000-0003-2156-254X</orcidid><orcidid>https://orcid.org/0000-0001-7644-2188</orcidid><orcidid>https://orcid.org/0000-0002-9627-3016</orcidid><orcidid>https://orcid.org/0000-0002-5871-7886</orcidid><orcidid>https://orcid.org/0000-0002-4231-5102</orcidid><orcidid>https://orcid.org/0000-0001-5445-9122</orcidid><orcidid>https://orcid.org/0000-0002-1855-8032</orcidid><orcidid>https://orcid.org/0000-0002-9998-8578</orcidid><orcidid>https://orcid.org/0000-0002-2874-0655</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-3692 |
| ispartof | Chest, 2024-06, Vol.165 (6), p.1307-1318 |
| issn | 0012-3692 1931-3543 1931-3543 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_04473459v1 |
| source | Alma/SFX Local Collection |
| subjects | ABPA Adrenal Cortex Hormones / therapeutic use Adult allergic bronchopulmonary aspergillosis Antifungal Agents / therapeutic use Aspergillosis, Allergic Bronchopulmonary / diagnostic imaging Aspergillosis, Allergic Bronchopulmonary / drug therapy Asthma / diagnostic imaging Asthma / drug therapy CT scan Female Human health and pathology Humans Itraconazole / therapeutic use Life Sciences Male Middle Aged radiologic response Tomography, X-Ray Computed / methods Treatment Outcome treatment outcomes |
| title | CT Imaging Assessment of Response to Treatment in Allergic Bronchopulmonary Aspergillosis in Adults With Bronchial Asthma |
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