Therapeutic Potential of Yersinia Anti-Inflammatory Components

Microbial pathogens have developed various stratagems for modulating and/or circumventing the host’s innate and adaptive immunity. Hence, certain virulence factors can be viewed as potential therapeutic agents for human immunopathological diseases. This is the case for virulence plasmid-encoded prot...

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Veröffentlicht in:	Advances in experimental medicine and biology 2007, Vol.603 (11), p.361-366
Hauptverfasser:	Foligné, Benoit, Dewulf, Joëlle, Pot, Bruno, Daniel, Catherine, Simonet, Michel, Poiret, Sabine, Marceau, Michaël, Dessein, Rodrigue
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Bacterial - genetics Antigens, Bacterial - immunology Colitis - immunology Colitis - prevention & control Humans Inflammation - immunology Inflammation - therapy Inflammatory Bowel Disease Inflammatory Bowel Disease Therapy Inflammatory Bowel Diseases - immunology Inflammatory Bowel Diseases - therapy Lactococcus lactis - genetics Lactococcus lactis - immunology Life Sciences Mice Pathogenic Yersinia Pore Forming Cytotoxic Proteins - genetics Pore Forming Cytotoxic Proteins - immunology TNBS Administration Trinitrobenzenesulfonic Acid - toxicity Ulcerative Colitis Virulence Factors - therapeutic use Yersinia - genetics Yersinia - immunology Yersinia - pathogenicity
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Beschreibung
Zusammenfassung:	Microbial pathogens have developed various stratagems for modulating and/or circumventing the host’s innate and adaptive immunity. Hence, certain virulence factors can be viewed as potential therapeutic agents for human immunopathological diseases. This is the case for virulence plasmid-encoded proteins from pathogenic Yersiniae that inhibit the host’s inflammatory response by interfering with various cellular signaling pathways.
ISSN:	0065-2598 1553-7390 2214-8019 1553-7404
DOI:	10.1007/978-0-387-72124-8_33