Semisynthetic Derivatives of Sissotrin Isolated from Trifolium baccarinii Chiov. (Fabaceae) and Evaluation of Their Antibacterial Activities
Starting from sissotrin (1), a natural isoflavonoid isolated from Trifolium baccarinii (Fabaceae), one new semisynthetic derivative, 6-nitrobiochanin A (1b) and two known derivatives, 8-nitrobiochanin A (1a) and 2",3",4",6"-tetraacetylsissotrin (1c) have been obtained after perfo...
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| Veröffentlicht in: | Advances in biological chemistry 2024, Vol.14 (1), p.27-39 |
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| container_title | Advances in biological chemistry |
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| creator | Tsamo, Donald Léonel Feugap Tagousop, Cyrille Ngoufack Dongmo, Arnaud Joseph Nguetse Voutquenne-Nazabadioko, Laurence Ngnokam, David |
| description | Starting from sissotrin (1), a natural isoflavonoid isolated from Trifolium baccarinii (Fabaceae), one new semisynthetic derivative, 6-nitrobiochanin A (1b) and two known derivatives, 8-nitrobiochanin A (1a) and 2",3",4",6"-tetraacetylsissotrin (1c) have been obtained after performing nitration and acetylation reactions. Their structures were assigned after interpretation of their spectrometric (HR-ESI-MS) and spectroscopic (NMR 1D and 2D) data and by comparison with those reported in the literature. The substrate as well as the semisynthetic derivatives were evaluated for their antibacterial activities against six strains. The results reveal that they are inactive or weakly active on the strains tested with the exception of 8-nitrobiochanin A (1a) which showed moderate activity (MIC = 62.5 μg∙mL−1) on Staphylococcus aureus ATCC 43300. |
| doi_str_mv | 10.4236/abc.2024.141003 |
| format | Article |
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(Fabaceae) and Evaluation of Their Antibacterial Activities</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Tsamo, Donald Léonel Feugap ; Tagousop, Cyrille Ngoufack ; Dongmo, Arnaud Joseph Nguetse ; Voutquenne-Nazabadioko, Laurence ; Ngnokam, David</creator><creatorcontrib>Tsamo, Donald Léonel Feugap ; Tagousop, Cyrille Ngoufack ; Dongmo, Arnaud Joseph Nguetse ; Voutquenne-Nazabadioko, Laurence ; Ngnokam, David</creatorcontrib><description>Starting from sissotrin (1), a natural isoflavonoid isolated from Trifolium baccarinii (Fabaceae), one new semisynthetic derivative, 6-nitrobiochanin A (1b) and two known derivatives, 8-nitrobiochanin A (1a) and 2",3",4",6"-tetraacetylsissotrin (1c) have been obtained after performing nitration and acetylation reactions. Their structures were assigned after interpretation of their spectrometric (HR-ESI-MS) and spectroscopic (NMR 1D and 2D) data and by comparison with those reported in the literature. The substrate as well as the semisynthetic derivatives were evaluated for their antibacterial activities against six strains. 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| subjects | Botanics Chemical Sciences Life Sciences Medicinal Chemistry Vegetal Biology |
| title | Semisynthetic Derivatives of Sissotrin Isolated from Trifolium baccarinii Chiov. (Fabaceae) and Evaluation of Their Antibacterial Activities |
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