Evaluation of erythropoietin biosimilars Epotin™, Hemax® and Jimaixin™ by electrophoretic methods used for doping control analysis and specific N-glycan analysis revealed structural differences from original epoetin alfa drug Eprex

•Glycosylations of Epotin™, Hemax® and Jimaixin™ were analyzed for the first time.•Antidoping methods and criteria were used to evaluate the Biosimilars.•Electrophoretic methods revealed differences from the original rEPO drug.•N-glycan analysis by MALDI-TOF MS confirmed structural differences.•N-gl...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2021-02, Vol.194, p.113750-113750, Article 113750
Hauptverfasser:	Capdeville, Perrine, Martin, Laurent, Cholet, Sophie, Damont, Annelaure, Audran, Michel, Ericsson, Magnus, Fenaille, François, Marchand, Alexandre
Format:	Artikel
Sprache:	eng
Schlagworte:	Doping detection Electrophoretic separation Erythropoietin biosimilar Life Sciences Mass spectrometry N-glycosylations
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!