Synthesis of a Functionalized Salen−Copper Complex and Its Interaction with DNA
An original procedure for efficient synthesis of a functionalized salen·copper complex is reported. The mode of binding to DNA of the salen·CuII complex was investigated by viscometry as well as by absorption, circular, and linear dichroism spectroscopy. The complex can induce DNA strand breakage in...
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| Veröffentlicht in: | Journal of organic chemistry 1996-04, Vol.61 (7), p.2326-2331 |
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| container_end_page | 2331 |
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| container_issue | 7 |
| container_start_page | 2326 |
| container_title | Journal of organic chemistry |
| container_volume | 61 |
| creator | Routier, Sylvain Bernier, Jean-Luc Waring, Michael J Colson, Pierre Houssier, Claude Bailly, Christian |
| description | An original procedure for efficient synthesis of a functionalized salen·copper complex is reported. The mode of binding to DNA of the salen·CuII complex was investigated by viscometry as well as by absorption, circular, and linear dichroism spectroscopy. The complex can induce DNA strand breakage in the presence of a reducing agent as revealed by a plasmid cleavage assay. The spectroscopic and biochemical data indicate that the salen·CuII complex induces single-stranded breaks via an interaction within one of the grooves of the double helix. |
| doi_str_mv | 10.1021/jo951840c |
| format | Article |
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The mode of binding to DNA of the salen·CuII complex was investigated by viscometry as well as by absorption, circular, and linear dichroism spectroscopy. The complex can induce DNA strand breakage in the presence of a reducing agent as revealed by a plasmid cleavage assay. The spectroscopic and biochemical data indicate that the salen·CuII complex induces single-stranded breaks via an interaction within one of the grooves of the double helix.</description><identifier>ISSN: 0022-3263</identifier><identifier>EISSN: 1520-6904</identifier><identifier>DOI: 10.1021/jo951840c</identifier><language>eng</language><publisher>American Chemical Society</publisher><subject>Chemical Sciences ; Medicinal Chemistry ; Organic chemistry</subject><ispartof>Journal of organic chemistry, 1996-04, Vol.61 (7), p.2326-2331</ispartof><rights>Copyright © 1996 American Chemical Society</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a329t-8fe8404754af6b3054ef3fa4ab98285259c0772603b6bc33c15d1fcc74ea59b23</citedby><cites>FETCH-LOGICAL-a329t-8fe8404754af6b3054ef3fa4ab98285259c0772603b6bc33c15d1fcc74ea59b23</cites><orcidid>0000-0002-2823-0591</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jo951840c$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jo951840c$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>230,314,780,784,885,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttps://hal.science/hal-04451628$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Routier, Sylvain</creatorcontrib><creatorcontrib>Bernier, Jean-Luc</creatorcontrib><creatorcontrib>Waring, Michael J</creatorcontrib><creatorcontrib>Colson, Pierre</creatorcontrib><creatorcontrib>Houssier, Claude</creatorcontrib><creatorcontrib>Bailly, Christian</creatorcontrib><title>Synthesis of a Functionalized Salen−Copper Complex and Its Interaction with DNA</title><title>Journal of organic chemistry</title><addtitle>J. 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Org. Chem</addtitle><date>1996-04-05</date><risdate>1996</risdate><volume>61</volume><issue>7</issue><spage>2326</spage><epage>2331</epage><pages>2326-2331</pages><issn>0022-3263</issn><eissn>1520-6904</eissn><abstract>An original procedure for efficient synthesis of a functionalized salen·copper complex is reported. The mode of binding to DNA of the salen·CuII complex was investigated by viscometry as well as by absorption, circular, and linear dichroism spectroscopy. The complex can induce DNA strand breakage in the presence of a reducing agent as revealed by a plasmid cleavage assay. The spectroscopic and biochemical data indicate that the salen·CuII complex induces single-stranded breaks via an interaction within one of the grooves of the double helix.</abstract><pub>American Chemical Society</pub><doi>10.1021/jo951840c</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-2823-0591</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3263 |
| ispartof | Journal of organic chemistry, 1996-04, Vol.61 (7), p.2326-2331 |
| issn | 0022-3263 1520-6904 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_04451628v1 |
| source | ACS Publications |
| subjects | Chemical Sciences Medicinal Chemistry Organic chemistry |
| title | Synthesis of a Functionalized Salen−Copper Complex and Its Interaction with DNA |
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