Positron Emission Tomography with [18F]‐DPA‐714 Unveils a Smoldering Component in Most Multiple Sclerosis Lesions which Drives Disease Progression

Objective To determine the prognostic value of persisting neuroinflammation in multiple sclerosis (MS) lesions, we developed a 18 kDa‐translocator‐protein‐positron emission tomography (PET) ‐based classification of each lesion according to innate immune cell content and localization. We assessed the...

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Veröffentlicht in:	Annals of neurology 2023-08, Vol.94 (2), p.366-383
Hauptverfasser:	Hamzaoui, Mariem, Garcia, Jeanne, Boffa, Giacomo, Lazzarotto, Andrea, Absinta, Martina, Ricigliano, Vito A.G., Soulier, Theodore, Tonietto, Matteo, Gervais, Philippe, Bissery, Anne, Louapre, Céline, Bottlaender, Michel, Bodini, Benedetta, Stankoff, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	Atrophy Autoimmune diseases Binding Computer Science Fluorine isotopes Gadolinium Human health and pathology Immune system Inflammation Lesions Life Sciences Localization Magnetic resonance imaging Medical Imaging Multiple sclerosis Neurodegeneration Neuroimaging Patients Phenotypes Positron emission Positron emission tomography Smoldering Substantia alba Tomography
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