Chk1 dynamics in G2 phase upon replication stress predict daughter cell outcome

In human cells, ATR/Chk1 signaling couples S phase exit with the expression of mitotic inducers and prevents premature mitosis upon replication stress (RS). Nonetheless, under-replicated DNA can persist at mitosis, prompting chromosomal instability. To decipher how the DNA replication checkpoint (DR...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Developmental cell 2022-03, Vol.57 (5), p.638-653.e5
Hauptverfasser:	Lebrec, Vivianne, Poteau, Marion, Morretton, Jean-Philippe, Gavet, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	cell cycle recovery checkpoint adaptation checkpoint kinase 1 Checkpoint Kinase 1 - genetics Checkpoint Kinase 1 - metabolism DNA Damage DNA Replication DNA replication checkpoint FRET biosensor G2 Phase Humans Life Sciences Mitosis replication stress S Phase Signal Transduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!