ERCC1 and MUS81–EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis

Breakage and rearrangement of common fragile sites (CFSs) can cause genomic instability. Rosselli and colleagues demonstrate that the endonuclease subunit ERCC1 and the endonuclease MUS18–EME1 are recruited to FANCD2-binding CFSs in mitosis to mediate their processing. Chromosomal instability (CIN)...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature cell biology 2013-08, Vol.15 (8), p.1008-1015
Hauptverfasser:	Naim, Valeria, Wilhelm, Therese, Debatisse, Michelle, Rosselli, Filippo
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/1405 631/337/1427 631/80/641/151/2357 631/80/641/1655 Analysis Anemia Blotting, Western Cancer Cancer Research Cell Biology Cell Line Chromatids - metabolism Chromosomal Instability Chromosome Fragile Sites - physiology Chromosome replication Chromosomes Deoxyribonucleic acid Developmental Biology DNA DNA Breaks DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Down-Regulation Endonucleases - genetics Endonucleases - metabolism Fanconi's anemia Fibroblasts Genomes Health aspects HeLa Cells Humans letter Life Sciences Localization Lymphocytes Membrane Proteins Microscopy, Confocal Mitosis - physiology Models, Biological Neoplasm Proteins Proteins RNA, Small Interfering Stem Cells Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!