A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

Mitochondrial activity is controlled by proteins encoded by both nuclear and mitochondrial DNA. Here, we identify Sirt7 as a crucial regulator of mitochondrial homeostasis. Sirt7 deficiency in mice induces multisystemic mitochondrial dysfunction, which is reflected by increased blood lactate levels,...

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Veröffentlicht in:	Cell metabolism 2014-11, Vol.20 (5), p.856-869
Hauptverfasser:	Ryu, Dongryeol, Jo, Young Suk, Lo Sasso, Giuseppe, Stein, Sokrates, Zhang, Hongbo, Perino, Alessia, Lee, Jung Uee, Zeviani, Massimo, Romand, Raymond, Hottiger, Michael O., Schoonjans, Kristina, Auwerx, Johan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Aging Amino Acid Sequence Animals Cellular Biology GA-Binding Protein Transcription Factor - analysis GA-Binding Protein Transcription Factor - metabolism Gene Knockout Techniques Humans Life Sciences Mice Mice, Knockout Mitochondria - genetics Mitochondria - metabolism Mitochondria - pathology Molecular Sequence Data Sequence Alignment Sirtuins - analysis Sirtuins - genetics Sirtuins - metabolism
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