APN/CD13 is over‐expressed by Psoriatic fibroblasts and is modulated by CGRP and IL‐4 but not by retinoic acid treatment

Psoriasis vulgaris is a common skin inflammatory disease characterized by recurrent flare episodes associated with scaly well‐demarcated skin plaques. Skin biopsies from psoriatic patients with high PASI score (22.67 ± 8.67) and from HD were used to study APN/CD13. APN/CD13 is over‐expressed in LP a...

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Veröffentlicht in:	Journal of cellular physiology 2018-02, Vol.233 (2), p.958-967
Hauptverfasser:	Gerbaud, Pascale, Guibourdenche, Jean, Jarray, Rafika, Conti, Marc, Palmic, Patricia, Leclerc‐Mercier, Stéphanie, Bruneau, Julie, Hermine, Olivier, Lepelletier, Yves, Raynaud, Françoise
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged aminopeptidase‐N Blocking antibodies Calcitonin Calcitonin gene-related peptide Calcitonin Gene-Related Peptide - pharmacology Case-Control Studies CD13 antigen CD13 Antigens - genetics CD13 Antigens - metabolism Cells, Cultured CGRP Enzymatic activity Female Fibroblasts Fibroblasts - drug effects Fibroblasts - enzymology Fibroblasts - pathology Gene expression Humans Interleukin 4 Interleukin-4 - pharmacology Life Sciences Male Middle Aged Overexpression Plaques Psoriasis Psoriasis - enzymology Psoriasis - genetics Psoriasis - pathology Psoriasis vulgaris Retinoic acid Skin Skin - drug effects Skin - enzymology Skin - pathology Skin diseases Time Factors Tretinoin - pharmacology Up-Regulation
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